Correlation between plasma B-type natriuretic peptide levels and left ventricular diastolic function using color kinetic imaging

Harada, Masahiko; Hara, Fumihiko; Yamazaki, Junichi

doi:10.1016/j.jjcc.2010.03.003

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…The plasma BNP levels reflect left ventricular end-diastolic wall stress more than any other systolic and diastolic HF parameter. The BNP level is usually higher in systolic HF since the end-diastolic wall stress is higher in systolic than in diastolic HF [22]. As in our study, most patients have normal EF, so acute HF was due to diastolic HF secondary to HTN.…”

Section: Discussionsupporting

confidence: 59%

Relationship between noninvasive central blood pressure and brain natriuretic peptide levels in patients with hypertensive pulmonary edema

Algowhary

Razik

Youssef

et al. 2021

Blood Pressure Monitoring

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Objective Hypertensive pulmonary edema is a fatal condition unless early and properly diagnosed and managed. Central blood pressure (cBP) has been proven to be more associated with adverse cardiovascular events. We aimed to study the correlation between cBP and heart damage in patients with Hypertensive pulmonary edema. Methods We included 50 patients admitted to the emergency department in a university hospital for hypertensive pulmonary edema, 27 women and 23 men aged 50 to 70 years. We excluded patients with suspected acute coronary syndrome, significant valvular heart disease, and pericardial diseases. We measured cBP non-invasively from pulse wave analysis of the brachial artery. Brain natriuretic peptide (BNP) and cBP were repeatedly measured for every patient. Results The median BNP levels of patients significantly decreased from 284 pg/ml (232–352.5) to 31.5 pg/ml (24–54) on discharge, P < 0.001. We found a significant correlation between admission BNP and central SBP (cSBP), urea, creatinine, arterial blood gases parameters, and left ventricular end-diastolic diameter (LVEDD). Concurrently, BNP at discharge was correlated with age, central DBP (cDBP), urea, creatinine, LVEDD, partial oxygen pressure (pO2), and oxygen saturation (SO2). Delta BNP was correlated with cSBP, peripheral SBP, urea, creatinine, pO2, and SO2. Linear regression analysis revealed that creatinine, and cSBP, were independent predictors of admission BNP, while urea and cDBP were the independent predictors of discharge BNP. Conclusion This simple, noninvasive method of cBP measurement was significantly associated with the extent of myocardial damage in patients presenting with hypertensive pulmonary edema.

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Section: Discussionsupporting

confidence: 59%

Relationship between noninvasive central blood pressure and brain natriuretic peptide levels in patients with hypertensive pulmonary edema

Algowhary

Razik

Youssef

et al. 2021

Blood Pressure Monitoring

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“…First, we did not take left atrial volume index [31] into account, for the assessment of diastolic dysfunction has been done in other studies [32][33][34]. Second, although atrial fibrillation may increase the risk of diastolic heart failure, we excluded such patients, as has been done in other studies [35], due to an inability to assess E/A. Third, not all patients who were diagnosed to have diastolic dysfunction in the current study manifested heart failure symptoms.…”

Section: Discussionmentioning

confidence: 99%

Association between circulating FGF23, α-Klotho, and left ventricular diastolic dysfunction among patients with preserved ejection fraction

et al. 2014

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Besides regulating calcium-phosphate metabolism, fibroblast growth factor-23 (FGF23) and Klotho have been proposed to have other roles in heart and vasculature. For example, FGF23 has been associated with cardiac hypertrophy and reduced left ventricular ejection fraction among patients with chronic kidney disease and cardiovascular disorders. The purpose of the study was to investigate whether serum FGF23 and α-Klotho concentrations are associated with cardiac diastolic dysfunction and related parameters among cardiac patients with preserved left ventricular ejection fraction. The current study enrolled 269 patients (69 women, 200 men) who were admitted to our cardiology department between October 2012 and January 2014 and had a left ventricular ejection fraction of >50%. Cardiac diastolic function was assessed by blood flow and tissue Doppler velocities, plasma B-type natriuretic peptide (BNP) concentration, and cardiac hypertrophy. After adjusting for sex, and age, logistic regression analysis showed that log(α-Klotho), but not log(FGF23), was significantly associated with diastolic dysfunction. After further adjustment for renal function, blood hemoglobin, and serum albumin levels, the negative association between log(α-Klotho) and diastolic dysfunction retained statistical significance with an odds ratio of 0.50 (95% confidence interval 0.31-0.81, P = 0.005, per 1 standard deviation). Among patients with preserved LVEF, serum α-Klotho concentrations were negatively associated with diastolic dysfunction. Whether modulation of serum levels α-Klotho will ameliorate cardiac diastolic function among patients with this disorder awaits further investigation.

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“…The results of E/e ratio, peak e wave velocity, and PCWP suggest no diastolic dysfunction in our patients who received HTx. Higher levels of B-type natriuretic peptide are another standard marker of diastolic dysfunction [19,20], but the plasma concentrations of Btype natriuretic peptide generally elevate above normal range until 3 weeks after the cardiac operation despite no obvious cardiac impairment [21], and therefore, cannot be a reliable marker early after HTx.…”

Section: Discussionmentioning

confidence: 99%

An elevated ratio of early to late diastolic filling velocity recovers after heart transplantation in a time-dependent manner

Imamura

Kinugawa

Shiga

et al. 2012

Journal of Cardiology

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Background: Several groups have reported that an elevated ratio of early (E) to late (A) diastolic filling velocities is observed in patients after heart transplantation. However, the mechanism has not been fully analyzed. Methods: Serial echocardiography and hemodynamic study were performed in 16 patients who had received heart transplantation and had no evidence of rejection during 1 month after the operation. Results: On Day 1 after the surgery, E/A ratio was higher and peak velocity of A wave was lower than normal range among the patients after heart transplantation. E/A ratio and peak velocity of A wave gradually normalized during 1 moth after the surgery. Meanwhile, early mitral annular velocity and pulmonary capillary wedge pressure remained within normal range during the study period. Conclusions: Longer ischemic time during heart transplantation procedure may cause atrial stunning, but it appears to recover within 1 month. We have to be alert to misinterpretation of this "psuedopsuedonormal" mitral inflow pattern early after transplantation.

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Correlation between plasma B-type natriuretic peptide levels and left ventricular diastolic function using color kinetic imaging

Abstract: Our results suggest that the plasma BNP level may be related to LV relaxation. The analysis of diastolic CK may be useful for quantitative assessment of LV diastolic function in patients with heart failure.

Cited by 5 publications

References 37 publications

Relationship between noninvasive central blood pressure and brain natriuretic peptide levels in patients with hypertensive pulmonary edema

Relationship between noninvasive central blood pressure and brain natriuretic peptide levels in patients with hypertensive pulmonary edema

Association between circulating FGF23, α-Klotho, and left ventricular diastolic dysfunction among patients with preserved ejection fraction

An elevated ratio of early to late diastolic filling velocity recovers after heart transplantation in a time-dependent manner

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