Correlation between plasmatic levels of vitamin D and PASI score

Mattozzi, Carlo; Paolino, Giovanni; Salvi, Monica; Macaluso, Laura; Scarnò, Marco; Vita, Gaetano De; Calvieri, Stefano; Richetta, Antonio Giovanni

doi:10.23736/s0392-0488.17.05622-x

Cited by 12 publications

(11 citation statements)

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“…In the current study, there was a signi cant decrease in the levels of serum vitamin D in severe psoriasis patient group compared with mild disease group whereas non-signi cant difference existed between mild cases and moderate cases which is in agreement with the study byAbdalla and Abdrabo [56]. Mattozzi et al signi cantly related severity of disease with reduced serum vitamin D levels[57]. In fact, the high prevalence of vitamin D insu ciency is de ned as a global health problem, and most experts recommend a level ≥ 30 ng/ml as su cient[58].…”

supporting

confidence: 92%

Vitamin D status in Psoriasis: Impact and Clinical Correlations

Bhat

Guldin

Khan

et al. 2022

Preprint

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Psoriasis is a continuing, periodic, immune‑mediated, fiery skin disease branded by hyper proliferation of epidermal keratinocytes and accompanying with inflammatory cellular infiltrate in both dermis and epidermis. Immunomodulation could be an important effect of vitamin D in Psoriasis. This case-control study was designed to measure serum 25-hydroxy vitamin D levels in patients with psoriasis and healthy controls and to find out clinical correlation, if any. Two hundred forty (n=240) subjects (120 cases and 120 controls) were taken for the study. Cases and controls were frequency matched with respect to age, gender and smoking status. Various demographic and clinical details were taken using a questionnaire. Chemiluminescence Micro Particle Immunoassay was used to estimate serum 25-hydroxy vitamin D levels. The vitamin D deficiency in psoriasis patients was 60.0% vs. 17.5% in controls (P<0.001) with mean vitamin D levels of 28.3 ± 13.9 ng/ml in psoriasis patient’s vs 37.9 ± 9.7 ng/ml in controls. Vitamin D deficiency was found to be associated with psoriasis independently of gender, age, smoking status, family history, hypertension, chronic medication, nail changes, duration of symptoms and severity of disease. Vitamin D levels were seven times lower in patients with Psoriasis as compared to controls. Reduced vitamin D levels are related to duration and clinical severity of the disease. Early detection of vitamin D deficiency and timely intervention could lead to better clinical outcome and improved quality of life in psoriasis patients.

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supporting

confidence: 92%

Vitamin D status in Psoriasis: Impact and Clinical Correlations

Bhat

Guldin

Khan

et al. 2022

Preprint

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“…Previous studies that tried to determine the association between circulating 25OHD and psoriasis severity presented inconsistent findings. Mattozzi et al showed that serum 25OHD level was significantly associated with the psoriasis area and severity index (PASI) score in patients with psoriasis ( 9 ). However, a randomized, double-blind, placebo-controlled trial (RCT) found that oral 25OHD3 supplementation did not significantly alleviate plaque psoriasis compared to the placebo ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the deficiency of 25OHD may contribute to the development of psoriasis via the reduction in immunomodulatory, anti-inflammatory, and antiproliferative activities. However, the causal relationship between 25OHD and risk of psoriasis and the disease severity of psoriasis has not been truly and consistently determined from previously retrospective and cross-sectional studies (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study

et al. 2022

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BackgroundPlenty of observational studies suggested that vitamin D concentrations were associated with psoriasis, but the causality of this relationship was elusive.ObjectiveTo investigate the causal relationship between vitamin D and psoriasis.MethodsCox proportional hazard model was used to investigate the association between vitamin D status and psoriasis in a prospective cohort study from UK Biobank. Single nucleotide polymorphisms (SNPs) that are strongly associated with circulating 25OHD were constructed as instrumental variables in Mendelian randomization (MR) to determine the causality between vitamin D and psoriasis.ResultsDuring a median follow-up of 10.99 years, we identified 2,856 participants with incident psoriasis. The prospective cohort study demonstrated individuals with 25OHD deficiency (< 25 nmol/L) at baseline were associated with approximately 20% increased risk of incident psoriasis in different categories of sex, age, and body mass index (BMI) after adjusting for covariates. The largest effect size was observed in the obese group (BMI > 30 kg/m2), as 25OHD deficiency presented with 30% additional risk of incident psoriasis compared to those with 25OHD > 50 nmol/L (HR = 0.701; 95% CI: 0.583–0.843; p < 0.001). Additionally, 69 independent SNPs associated with circulating 25OHD level were selected for the MR analysis, and the result suggested that genetically predicted one standard deviation (SD) increment in log-transformed 25OHD was associated with 24% decreased risk of psoriasis (OR = 0.76; 95% CI: 0.60–0.98, p = 0.020).LimitationsThe association of 25OHD and severity of psoriasis could not be estimated in the current study.ConclusionThe combined prospective and MR analysis additionally provided evidence that the epidemiologically and genetically determined level of 25OHD conferred an increased risk of psoriasis.

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“…Additionally, vitamin D regulates genes that encode activities of enzymes involved in Hcy metabolism. The cystathionine beta-synthase has been shown to be the target gene of VDR regulation, making the active form of vitamin D a potential regulator of Hcy metabolism [ 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have indicated that patients with psoriasis have low vitamin D blood level. Receptors for vitamin D (VDR) are located in various tissues and organs; therefore, it is not a surprise that vitamin D deficiency has been connected to a considerable number of illnesses and pathological conditions such as obesity, insulin resistance, arterial hypertension, and dyslipidemia [ 19 , 20 ]. Vitamin D supplementation has been used in psoriasis for years and the mechanism of its efficiency includes binding to VDR of epidermal keratinocytes, inducing their differentiation.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Three-Month Vitamin D Supplementation on the Levels of Homocysteine Metabolism Markers and Inflammatory Cytokines in Sera of Psoriatic Patients

et al. 2021

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Psoriasis is an autoimmune and inflammatory skin disease. Psoriatic patients express higher levels of plasma homocysteine (Hcy) concentration and pro-inflammatory mediators than healthy people; this is frequently associated with vitamin D deficiency. The aim of this clinical study was to investigate the effects of high doses of vitamin D supplementation on the parameters of Hcy metabolism and cytokines in sera of psoriatic patients. This prospective study was conducted on 40 psoriatic patients who had the vitamin D deficiency. All patients received vitamin D 5000 IU/day for three months. Clinical and biochemical measurements were taken at baseline and at follow up (3 months). The results showed that the severity of clinical features, measured by the psoriasis area severity index (PASI) score, were considerably improved in patients after vitamin D supplementation. After vitamin D supplementation, most of the patients (n = 25 or 62.5%) had mild clinical form (p < 0.001). After twelve weeks of intervention period, there were significant increases in vitamin D and B12 serum levels in comparison to the levels that had been measured at the beginning of the study (56.77 ± 14.66 nmol/L and 301.08 ± 95.02 pg/mL vs. 103.85 ± 32.20 nmol/L and 362.81 ± 118.56 pg/mL, respectively; p < 0.001). Moreover, serum levels of Hcy and folate were significantly lower at the end of the study in comparison with the initial levels (12.45 ± 1.92 µmol/L and 8.01 ± 3.88 mg/mL vs. 10.38 ± 1.66 µmol/L and 6.27 ± 2.60 mg/mL, respectively). High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN-ɤ, TNF-α, IL-1β, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated. In conclusion, supplementation with high doses of vitamin D could be one of the possible preventive and therapeutic measures to reduce systemic inflammation in psoriatic patients.

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Correlation between plasmatic levels of vitamin D and PASI score

Cited by 12 publications

References 0 publications

Vitamin D status in Psoriasis: Impact and Clinical Correlations

Vitamin D status in Psoriasis: Impact and Clinical Correlations

Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study

The Effect of Three-Month Vitamin D Supplementation on the Levels of Homocysteine Metabolism Markers and Inflammatory Cytokines in Sera of Psoriatic Patients

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