Correlation Between Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross-Sectional Study

Duan, Yanan; Peng, Yiqing; Shi, Xiulin; Zhao, Ying; Liu, Kunyan; Zhou, Runsheng; Peng, Cunxu

doi:10.1155/2022/3257887

Cited by 6 publications

(8 citation statements)

References 37 publications

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“…However, PLT and PLR cannot fully reflect the inflammatory state and immune response to TBI; they can only be used to assess inflammatory indicators of hemorrhage and affect coagulation function after TBI. [16] Further, the significance of PLR-related outcomes as an independent predictor of prognosis in TBI patients was also demonstrated by the study of Chen et al (2023) in 1009 patients assessed using GOS after 6 months with P < 0.001 and AUC 0.636 (95% CI 0.660-0.670). [7] However, opposite results were shown in a prospective study by Bilgi et al (2021) on 96 patients who assessed hematological parameters using GOSE with the IMPACT and CRASH prognostic models and assessed the ability of predictors of mortality and morbidity and found that PLR was said to be less able to be used as a predictor of mortality or a good neurological outcome with AUC 0.58 (95%CI 0.42-0.73; P = 0.110), OR 1.01, P = 0.11; AUC 0.53 (95%CI 0.38-0.68; P = 0.360), respectively, compared to the international normalized ratio, total leukocyte count, and transfusion of blood products, which were considered statistically significant in predicting.…”

Section: Results Of Synthesismentioning

confidence: 75%

“…[9] A retrospective investigation of TBI was carried out on 192 individuals who had undergone unilateral decompressive craniectomy. [16] After decompressive surgery, the PLR was calculated, patients were followed up 6 months after treatment, and GOS scoring was conducted. It was discovered that PLR, along with other parameters, was substantially correlated with the clinical prognosis of TBI, despite the fact that PLR could not fully reflect the extent of inflammation and immune response to TBI.…”

Section: Gosmentioning

confidence: 99%

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Platelet-to-lymphocyte ratio as a prognostic predictive marker on adults with traumatic brain injury: Systematic review

Ilyas,

Lado,

Budiono

et al. 2024

Surgical Neurology International

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Background: The platelet-to-lymphocyte ratio (PLR) has emerged as a prognostic predictive marker in various diseases, but its role in traumatic brain injury (TBI) has not been fully elucidated. This study aims to evaluate the role of PLR as a prognostic predictive marker in adults with TBI. Methods: This systematic review was conducted according to the Preferred Reporting Items in the Systematic Review and Meta-analysis Guidelines 2020. A comprehensive search was performed using PubMed, Google Scholar, Scopus, Crossref, OpenAlex, Semantic Scholar, Library of Congress, and Jisc Library Hub Discover database to identify relevant studies published up to February 2023. Both prospective and retrospective observational studies written in English or Indonesian were included in the study. No restrictions were placed on the year and country of publication and duration of follow-up. Study quality was evaluated using the Newcastle-Ottawa Scale (NOS), and the risk of bias was estimated using the Cochrane Risk of Bias Assessment Tool for Nonrandomized Research (Ro-BANS) tool. A narrative synthesis was also conducted to summarize the findings. Results: We retrieved 1644 references using the search strategy, and 1623 references were excluded based on screening the title and abstract. The full text was retrieved for 20 articles and subjected to the eligibility criteria, of which 16 were excluded from the study. Four papers with a total of 1.467 sample sizes were included in the review. The median of NOS for study quality was 8–9, with the risk of selection bias using the Ro-BANS tool being low in all studies except for the blinding outcome assessments, which are all unclear. The study finding suggests that the PLR has the potential as an independent prognostic predictive marker in adult patients with TBI. In three studies, a high level of admission PLR may independently predict an increasing mortality risk in 30 days and adverse outcomes measured by the Glasgow outcome scale in 6 months following TBI. However, one study shows that PLR may have limited value as a predictor of mortality or favorable neurological outcomes compared to other hematological parameters. Further studies were needed to establish the clinical utility of PLR and fill the present gaps. Conclusion: This systematic review provides evidence supporting the utilization of PLR as a prognostic predictive marker in adult patients with TBI. The PLR can mainly be utilized, especially in rural practice, as PLR is a simple, low-cost, and routinely performed hematological examination.

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Section: Results Of Synthesismentioning

confidence: 75%

Section: Gosmentioning

confidence: 99%

Platelet-to-lymphocyte ratio as a prognostic predictive marker on adults with traumatic brain injury: Systematic review

Ilyas,

Lado,

Budiono

et al. 2024

Surgical Neurology International

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“…Disruptions in gastrointestinal ecology actively contribute to the development and metastasis of gynecological tumors, such as cervical cancer, endometrial cancer, and ovarian cancer 72 . Notably, several studies have revealed that the use of probiotics can ameliorate depressive symptoms and regulate sex hormone levels, offering potential therapeutic benefits for women with PCOS and gestational diabetes 73 – 75 .Besides, chronic inflammation and oxidative stress are prominent features of depression 76 , 77 and pathological conditions pertaining to female reproductive health, including PCOS, ovarian dysfunction, endometriosis, gestational diabetes, and leiomyoma of uterus 78 – 82 . Inflammatory processes are intertwined with the onset of depression, which can further exacerbate the inflammatory response and detrimentally impact the reproductive system 83 – 85 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study

Ling,

Dai,

Weng

et al. 2024

Sci Rep

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Observational studies have previously reported an association between depression and certain female reproductive disorders. However, the causal relationships between depression and different types of female reproductive disorders remain unclear in terms of direction and magnitude. We conducted a comprehensive investigation using a two-sample bi-directional Mendelian randomization analysis, incorporating publicly available GWAS summary statistics. Our aim was to establish a causal relationship between genetically predicted depression and the risk of various female reproductive pathological conditions, such as ovarian dysfunction, polycystic ovary syndrome(PCOS), ovarian cysts, abnormal uterine and vaginal bleeding(AUB), endometriosis, leiomyoma of the uterus, female infertility, spontaneous abortion, eclampsia, pregnancy hypertension, gestational diabetes, excessive vomiting in pregnancy, cervical cancer, and uterine/endometrial cancer. We analyzed a substantial sample size, ranging from 111,831 to 210,870 individuals, and employed robust statistical methods, including inverse variance weighted, MR-Egger, weighted median, and MR-PRESSO, to estimate causal effects. Sensitivity analyses, such as Cochran's Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis, and funnel plots, were also conducted to ensure the validity of our results. Furthermore, risk factor analyses were performed to investigate potential mediators associated with these observed relationships. Our results demonstrated that genetic predisposition to depression or dysthymia was associated with an increased risk of developing PCOS (OR = 1.43, 95% CI 1.28–1.59; P = 6.66 × 10–11), ovarian cysts (OR = 1.36, 95% CI 1.20–1.55; P = 1.57 × 10–6), AUB (OR = 1.41, 95% CI 1.20–1.66; P = 3.01 × 10–5), and endometriosis (OR = 1.43, 95% CI 1.27–1.70; P = 2.21 × 10–7) after Bonferroni correction, but no evidence for reverse causality. Our study did not find any evidence supporting a causal or reverse causal relationship between depression/dysthymia and other types of female reproductive disorders. In summary, our study provides evidence for a causal relationship between genetically predicted depression and specific types of female reproductive disorders. Our findings emphasize the importance of depression management in the prevention and treatment of female reproductive disorders, notably including PCOS, ovarian cysts, AUB, and endometriosis.

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“…9,10 There are associations between PLR and NLR, and solid tumors and metabolic disorders, respectively, according to a number of earlier research. [11][12][13][14] On the link between the numerous inflammatory signs in patients with infertility, there is, however, little research. In order to better understand how inflammation contributes to the onset and progression of infertility, the primary goal of this study was to define the relationships between PLR and NLR in women with infertility.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Markers in Women with Infertility: A Cross-Sectional Study

Duan¹,

Zhou²,

Peng³

et al. 2023

IJGM

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Infertility is highly correlated with inflammation. We sought to evaluate the independent relationships between each inflammatory marker in women with infertility. Patients and Methods: This cross-sectional study included 1028 infertile patients who were hospitalized at Jining Medical University between January 2016 and December 2022. NLR and PLR were the independent and dependent variables measured at baseline, respectively. Age, body mass index (BMI), and menstrual status were covariates. Based on BMI, the study population was split into two groups: Low-BMI and High-BMI. Results: A stratified analysis revealed that the overweight group had significantly higher levels of WBC, platelet count, lymphocyte count, neutrophil count and NLR. Comparing the overweight group to the normal weight group, the levels were noticeably higher in the overweight group. Significantly positive correlations between NLR and PLR were found in both univariate and multiple regression analyses. Conclusion:There was a significant positive correlation between NLR and PLR in infertility patients. These results will help in the search for biomarkers of infertility and in the development of infertility prediction models.

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Correlation Between Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross-Sectional Study

Cited by 6 publications

References 37 publications

Platelet-to-lymphocyte ratio as a prognostic predictive marker on adults with traumatic brain injury: Systematic review

Platelet-to-lymphocyte ratio as a prognostic predictive marker on adults with traumatic brain injury: Systematic review

Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study

Inflammatory Markers in Women with Infertility: A Cross-Sectional Study

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