Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester

Akgün, Hülya; Başbuğ, Mustafa; Özgün, Mahmut Tuncay; Canöz, Özlem; Tokat, Fatma; Murat, N.; Öztürk, Figen

doi:10.1002/pd.1710

Cited by 56 publications

(62 citation statements)

References 20 publications

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“…There is complete agreement of autopsy and US findings in 46% to 78.4% of cases. [3][4][5][6] Our study showed complete concordance in 72.5% of the cases. In 30 of 91 cases (33%), the autopsy changed the diagnosis or was essential to establish it.…”

Section: Discussionmentioning

confidence: 57%

Comparison of prenatal ultrasound findings and autopsy findings in fetuses terminated after prenatal diagnosis of malformations: An experience of a clinical genetics center

Phadke

Gupta

2010

J of Clinical Ultrasound

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Section: Discussionmentioning

confidence: 57%

Comparison of prenatal ultrasound findings and autopsy findings in fetuses terminated after prenatal diagnosis of malformations: An experience of a clinical genetics center

Phadke

Gupta

2010

J of Clinical Ultrasound

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“…This important issue is discussed widely elsewhere [15][16][17][18][19][20] . Many Israeli couples are reluctant to consent to post-abortion autopsy.…”

Section: Discussionmentioning

confidence: 99%

Termination of Pregnancy due to Fetal Abnormalities Performed after 23 Weeks’ Gestation: Analysis of Indications in 144 Cases from a Single Medical Center

Vaknin¹,

Lahat²,

Barel³

et al. 2009

Fetal Diagn Ther

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Background/Aims: To assess the indications for late termination (≥23 weeks’ gestation) of pregnancy (LTOP), and to evaluate the rate of cases potentially diagnosable earlier. Methods: Cases of singleton pregnancy ending in LTOP due to fetal abnormalities in our institute between 1/1998 and 12/2005 were retrospectively reviewed. The women were divided into two groups according to the sequence of events that led to LTOP: Group 1 – the first test indicating an abnormal finding was performed ≤23 weeks’ gestation, but LTOP was performed >23 weeks; Group 2 – the first test indicating an abnormal finding was performed ≥23 weeks of gestation, or the fetal prognosis was not certain at the time of diagnosis and there was a medical recommendation to continue investigation. Results: There were 144 cases of LTOP (average gestational age 26.2 ± 3.4 weeks). More than 70% of the cases were aborted because of chromosomal/genetic indication in Group 1; many of them could have been detected earlier in pregnancy, while about 80% of the cases were aborted because of structural abnormalities in Group 2 (p < 0.001). The structural anomaly could have been diagnosed earlier in 56 cases (∼74%) if the pregnant woman had undergone an earlier anomaly scan. In another 13 cases (9%), fetal prognosis was not certain and continuing prenatal investigation was required. Conclusions: The most common indications for LTOP were structural abnormalities (91 cases, 70%) which included the central nervous system (26 cases, 29%), cardiac abnormalities (24 cases, 26%), and multiple malformations (18 cases, 20%). The diagnosis of fetal anomaly could have been made earlier in more than half of the pregnant women undergoing LTOP.

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“…4 However, in up to one-quarter of cases, additional information which changes the underlying diagnosis or the information given to parents during counselling may be acquired from a formal autopsy. [5][6][7][8][9] This figure may be higher in paediatric rather than perinatal cases. 1 Several studies have also shown a significant discrepancy rate between what clinicians think is the cause of death and full traditional autopsy findings, 3,10 and error rates can be as high as 50% on medical certificates in stillbirths.…”

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confidence: 99%

Post-mortem MRI as an alternative to non-forensic autopsy in foetuses and children: from research into clinical practice

Addison¹,

Arthurs²,

Thayyil³

2014

BJR

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Although post-mortem MRI (PMMR) was proposed as an alternative to conventional autopsy more than a decade ago, the lack of systematic validation has limited its clinical uptake. Minimally invasive autopsy (MIA) using PMMR together with ancillary investigations has now been shown to be as accurate as conventional autopsy in foetuses, newborns and infants and is particularly useful for cerebral, cardiac and genitourinary imaging. Unlike conventional autopsy, PMMR provides a permanent three-dimensional auditable record, with accurate estimation of internal organ volumes. MIA is becoming highly acceptable to parents and professionals, and there is widespread political support and public interest in its clinical implementation in the UK. In the short to medium term, it is desirable that a supraregional network of specialist centres should be established to provide this service within the current National Health Service framework.

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Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester

Abstract: Evaluation of fetal autopsies following TOP enables diagnosis of pathologies undetected by prenatal ultrasound alone, leading to better preconceptional counseling for subsequent pregnancies.

Cited by 56 publications

References 20 publications

Comparison of prenatal ultrasound findings and autopsy findings in fetuses terminated after prenatal diagnosis of malformations: An experience of a clinical genetics center

Comparison of prenatal ultrasound findings and autopsy findings in fetuses terminated after prenatal diagnosis of malformations: An experience of a clinical genetics center

Termination of Pregnancy due to Fetal Abnormalities Performed after 23 Weeks’ Gestation: Analysis of Indications in 144 Cases from a Single Medical Center

Post-mortem MRI as an alternative to non-forensic autopsy in foetuses and children: from research into clinical practice

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