Correlation between Preoperative Anxiety and ABO Blood Types: Evidence from a Clinical Cross-Sectional Study

Abstract

Gene-environment interaction is identified as the determinant in anxiety. ABO blood types represent a part of the genetic phenotype. Therefore, we assume ABO blood types correlate with preoperative anxiety. This cross-sectional study enrolled 352 patients with different ABO blood types, scheduled for elective surgery between 2018 and 2019 in the First Affiliated Hospital of Shihezi University. HADS (hospital anxiety and depression scale) scores and VA (visual analogue scales for anxiety) scores were all used to assess the preoperative anxiety in the A, B, AB, and O groups. Bivariate correlation and logistic regression were performed to identify relationships between preoperative anxiety and related variables. A significant difference in VA and HADS-A (anxiety) scores was found between the AB and other groups. The ratio of preoperative anxiety was 3.73 (95% CI [confidence interval]: 2.32-6.00, P < 0.001) times in female than in male; 0.36 (95% CI: 0.21-0.63, P < 0.001) times in ASA (American Society of Anesthesiologists) grade II than in grade I; 0.41 (95% CI: 0.20-0.86, P < 0.05) times in ASA grade III than in grade I; 1.25 (95% CI: 1.1-1.41, P < 0.001) times in higher VAS (visual analogue scales for pain) scores than in lower VAS scores; and 0.28 (95% CI: 0.16-0.49, P < 0.01) times in non-AB blood type than in AB blood type. Differences in ABO blood types were found in preoperative anxiety, and the AB group displayed a high preoperative anxiety level. ABO blood types, sex, ASA grade, and VAS were associated with preoperative anxiety. This trial is registered with ChiCTR1800019390.

The relationship between preoperative anxiety level, ABO blood types and birth outcomes in cesarean sections

“…Observational studies investigating ABO blood types, preoperative anxiety and phenotypic factors are limited in the literature. To the best of our knowledge, a study examining ABO blood types and preoperative anxiety was found in the literature (11). In this study, POA levels of patients with AB blood group were found to be higher than those with other blood groups (11).…”

“…To the best of our knowledge, a study examining ABO blood types and preoperative anxiety was found in the literature (11). In this study, POA levels of patients with AB blood group were found to be higher than those with other blood groups (11).…”

“…When the literature was examined, in a study examining the relationship between dental anxiety and blood group in children, the highest level of dental anxiety was found in those with AB blood group (20). Similarly, Feng Xu et al (11), preoperative anxiety levels were found to be higher in people with AB blood type. In another study examining blood groups and stress levels, it was found that pathological and general stress levels were found in people with the lowest O blood group (21).…”

Personalized Preoperative Education Reduces Perioperative Anxiety in Old Men with Benign Prostatic Hyperplasia: A Retrospective Cohort Study

“…There are different personal factors that could contribute to the level of anxiety, such as gender [5], education level [18], ABO blood types [19], different type of surgeries, and period after surgery [20]. Anxiety in people aged 55 years and above is significantly lower in the married/ cohabitating group than that of the divorced/separated/ widowed group [21].…”

Association of the ABO blood group with certain human diseases

“…This topic received attention by the medical community as early as the 1960s of last century [29] . Recently, a clinical-cross sectional study evaluating the correlation between ABO blood types and preoperative anxiety was carried out [30] . It enrolled 352 patients with different ABO blood types scheduled for elective surgery and found the AB group displayed a high preoperative anxiety level.…”