Correlation between preoperative calcium and parathormone levels with parathyroid gland volume

Abstract

Objective. Hyperparathyroidism is a prevalent disease with parathyroid adenomas being the most common cause. Surgical excision remains the standard treatment for parathyroid adenoma. Successful preoperative localization of the parathyroid adenoma could facilitate the decision regarding the extent of surgical exploration. The aim of the current study was to assess the correlation between the preoperative values of parathyroid hormone and ionized calcium with the adenoma weight and volume in patient with primary hyperparathyroidism caused by single-gland adenoma. Patients and Methods. We did this retrospective review for all patients who were diagnosed with primary hyperparathyroidism due to a solitary parathyroid adenoma in our general surgery department over 4 years. SPSS software was used to get the correlation coefficient between the peak preoperative levels of calcium and parathyroid hormone with the parathyroid adenoma weight and volume. Results. Ninety-nine patients were included into the study. The average age at surgery was 62.65±12.00 years. The correlation coefficient between the adenoma volume and weight with the preoperative ionized calcium level was weakly positive (r=0.329, p<0.01) and (r=0.281, p=0.019), respectively, while the correlation with the preoperative parathyroid hormone level was stronger (r=0.708, p<0.01) and (r=0.650, p<0.01), respectively. Conclusions. The strong positive relationship between the preoperative parathyroid hormone and calcium levels with the parathyroid adenoma size and weight can help the surgeon to predict the volume of the involved gland and avoid an unnecessary dissection.

Differentiating pathologic parathyroid glands from thyroid nodules on neck ultrasound: the PARATH-US cross-sectional study

“…Previous studies have reported correlations between parathyroid size or weight and peripheral calcium or PTH levels. 17 , 21 , 39 However, compared with previous reports, we found the highest correlation coefficients. We collected calcium and PTH levels before any medical or nonmedical (i.e., hyperhydration) intervention.…”

Risk factors for hypocalcemia and correlation between thyroid volume and incidental parathyroidectomy after total thyroidectomy: single center experience

“…In a study, it was found that the risk of postoperative hypocalcemia increases as the thyroid gland volume decreases (23). In another study, it was reported that the risk of hypocalcemia increased in those with a small thyroid volume and the risk of bleeding in those with a large thyroid volume (24). In our study, it was determined that the increase in thyroid volume had a statistically significant effect on hypocalcemia, albeit at a low level.…”

Statistical method of multi-omics data integration and its application in cancer analysis

“…There are many methods to evaluate the correlation, such as Pearson correlation and Spearman correlation. The degree of connection between preoperative calcium and parathyroid hormone levels and parathyroid volume was assessed using the correlation coefficient by Emad R et al [7] . The research results will help the surgeon to predict operation to avoid unnecessary.…”