2011
DOI: 10.1159/000329371
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Correlation between Progressive Changes in Piriform Cortex and Olfactory Performance in Early Parkinson’s Disease

Abstract: Objectives: The mechanism underlying olfactory dysfunction in Parkinson’s disease (PD) remains unknown. The current study aims to investigate the relationship between sequential changes of volume change of cortex associated with olfactory function and degree of deficiency of olfactory performance in PD. Methods: Based on the arbitrary cut-off score of olfactory performance measured by ‘five odors olfactory detection arrays’, subjects were classified into three groups: PD patients with olfactory impairment (OPD… Show more

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Cited by 58 publications
(34 citation statements)
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References 94 publications
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“…For instance, olfactory dysfunction is considered as a relatively early or even preclinical sign in PD [3], while in later stages pathological changes in olfaction-related brain areas have been described [4]. Cortical atrophy has been demonstrated to correlate with olfactory dysfunction in PD [5]. Especially in later stages, cognitive impairment, including visuospatial dysfunction and alterations in executive functions, occurs relatively often in PD [6].…”
Section: Introductionmentioning
confidence: 99%
“…For instance, olfactory dysfunction is considered as a relatively early or even preclinical sign in PD [3], while in later stages pathological changes in olfaction-related brain areas have been described [4]. Cortical atrophy has been demonstrated to correlate with olfactory dysfunction in PD [5]. Especially in later stages, cognitive impairment, including visuospatial dysfunction and alterations in executive functions, occurs relatively often in PD [6].…”
Section: Introductionmentioning
confidence: 99%
“…Cortical thickness analysis has already been used to look at the normal thinning of the cortex with age (Salat et.al 2004), to see the changes in the brain after a sensory loss (Li et.al 2004), or if the brain differs from a control when one of the senses was never there (Frasnelli et.al 2013). It has been used to explore how diseases such as Parkinson's disease (Wu et.al 2011) and Alzheimer's disease (Li et.al 2012) affects the brain, and how an early start at life may affect the development of gray matter (Nagy, Lagercrantz & Hutton 2011, Kapellou et.al 2006, Martinussen et.al 2005, Nosarti et.al 2014.…”
Section: Discussionmentioning
confidence: 99%
“…Together all of these methods have been used to examine the effect of loss of a sense like hearing or smell (Li et.al 2012, Frasnelli et.al 2013, the effect of Alzheimers disease (Li et.al 2012), Parkinsons disease (Wu et.al 2011), and aging (Salat et.al 2004, Van Velsen et.al 2013. It has also been used to see the effect of a premature birth (Nagy, Lagercrantz & Hutton 2011, Kapellou et.al 2006, Martinussen et.al 2005, Nosarti et.al 2014, as well as the effect of psychiatric disorders such as bipolarity (Oertel -Knöchel et.al 2015, Giakoumatos et.al 2015, schizophrenia (Zugman et.al 2015), ADHD (Fernández-Jaén et.al 2015) and autism (Richter et.al 2015).…”
Section: Introductionmentioning
confidence: 99%
“…The ''five-odor olfactory detection array'', one of the Chinese olfactory tests, was applied [13][14][15]. The sensitivity of this test was 74.0% and the specificity was 91.7% as calculated in a previous study [16].…”
Section: Olfactory Testmentioning
confidence: 99%
“…The score was recorded as 3.5 and labeled as anosmia if the participant could not identify any odor. The severity of olfactory dysfunction was represented by the mean value of the combination of TOD and TOI scores for all five odors, based on which the participants were classified as normal (B1), mild hyposmia ([1, B2), and severe hyposmia ([2) [13,16].…”
Section: Olfactory Testmentioning
confidence: 99%