Correlation between prostate specific antigen, digital rectal examination and histology in patients with prostate cance

Mbaeri, TU; Nwadi, Uchenna V.; Abiahu, JA; Orakwe, JC; Okoli, Chinedu C

doi:10.4103/1115-2613.278783

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…In this study, we analyzed age, PSA, prostate volume, DRE, and Gleason score as predictors for positive biopsy findings, which were also recognized as such in the study by Mbaeri TU et al,conducted in Nigeria (25). The results of our study showed that total PSA is a predictor of a positive biopsy result in men older than 70 years (p=0.02), as in the study by Ferlay et al 26 The reason for this result may be that the prostate biopsy in the older population had higher PSA values than in the younger patients. Prostate volume was analyzed to examine the direct influence of prostate volume on the prediction of histopathological findings.…”

Section: Discussionsupporting

confidence: 82%

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Milutinovic,

Djordjevic,

Todorovic

et al. 2024

Experimental and Applied Biomedical Research (EABR)

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Prostate cancer is a worldwide health concern with an increasing global incidence. In the Republic of Serbia, it is the third most commonly diagnosed cancer in men. The research aims to determine the influence of PSA value and digital rectal examination on the pathohistological findings of prostate biopsy in men in Central Serbia. The study was designed as a retrospective, cross-sectional analytical study conducted in the period from December 2021 to December 2022 after receiving the confirmation of the Ethics Committee of the University of Applied Sciences Kragujevac. Among 151 respondents aged 49 to 88 who underwent consecutive biopsies during the study period, prostate cancer was detected in 65 (42%). Out of 65 positive biopsies, 33 subjects had a Gleason score of up to 7, while 32 subjects had a Gleason score over 7. Prostate biopsies significantly correlated with PSA levels (p=0.02), while DRE and prostate volume did not show statistical significance on the prostate biopsy result. PSA level testing leads to early detection of prostate disease in the elderly. PSA value was the only clinical variable associated with an increased rate of prostate cancer in men ≥ 70 and older (p=0.02). DRE, PSA, and prostate volume are important parameters associated with an increase in prostate cancer detection rate in men over 70 years of age.

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Section: Discussionsupporting

confidence: 82%

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Milutinovic,

Djordjevic,

Todorovic

et al. 2024

Experimental and Applied Biomedical Research (EABR)

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“…1). Studies were spread across six countries namely Nigeria (seven) [12,13,18,[23][24][25][26], South Africa (two) [27,28], Kenya (one) [29], Senegal (one) [30], Sudan (one) [31], and Tanzania (one) [32]. Of the 13 studies, ten studies reported sensitivity of PSA, specificity of PSA or both (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…We identified some studies that described sensitivity and specificity of PSA and digital rectal examination (DRE) (Table 3). It has been established that combination of PSA and DRE can be used to predict PCa, with sensitivity rates as high as 100% having been reported [23,25,32]. Milwa et al gave a diagnostic accuracy of 87% using DRE and PSA [35].…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of prostate-specific antigen and its surrogates towards the detection of prostate cancer in sub-Saharan Africa: a systematic review with meta-analysis

Okwor,

Nnakenyi,

Agbo

et al. 2023

Afr J Urol

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Background Racial disparities associated with pathogenesis and progression of prostate cancer makes a global diagnostic prostate-specific antigen (PSA) cut-off value inappropriate. Our review aimed to evaluate the pooled sensitivity and specificity of PSA and its surrogates, and to systematically synthesize the optimum thresholds for the detection of prostate cancer in sub-Saharan Africa. Methods This was a systematic review of 6861 peer-reviewed literature from five databases: MEDLINE, PubMed, CINAHL, African Journal Online and Academic Search Complete, last search was in September 2022. Studies reporting the diagnostic accuracy of PSA and/or its surrogates towards the detection of prostate cancer in patients, using histology of prostate biopsy as the reference test for cancer diagnosis, were included. Studies that did not report sensitivity and/or specificity, or histology diagnosis of prostate cancer were excluded. Risk of bias assessment was conducted using quality assessment of diagnostic accuracy studies (QUADAS) by two independent investigators. Random effect model of meta-analysis was performed using Comprehensive Meta-Analysis version 3. Results Thirteen (13) studies of males diagnosed with prostate cancer were included—10 studies reported PSA sensitivity/specificity/both; 4 reported on PSA surrogates (3 reported %freePSA, and 1 reported PSA density). We conducted 2 meta-analyses to pool the diagnostic accuracy of PSA and %freePSA. The sensitivity of PSA (n = 10) at the cut-off values of < 4 ng/ml, 4–10 ng/ml, > 10 ng/ml were 86.8%, 93.1%, and 76.0% respectively; while specificity (n = 8) were 42.3%, 29.3%, and 28.8% respectively. The PSA cut-off of 4–10 ng/ml possessed the highest diagnostic accuracy (55.7%). The specificity (91.5%) and diagnostic accuracy (84%) of %freePSA (n = 3) was best at cut-off value ≤ 10%. Conclusion Having the highest diagnostic accuracy individually, a combination of PSA 4–10 ng/ml and %freePSA ≤ 10% may be a more appropriate criteria for deciding eligibility for prostate biopsy among males in sub-Saharan Africa.

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“…Vol.12; Issue: 3; March 2022 low specificity is in sync with that observed in other studies (Table 10). [12] Deepak Panasseril Jayapradeep et al (2017) [11] Ghafoori M et al (2009) [16] Mbaeri TU et al (2018) [18] Bannakij Lojanapiwat et al (2014) [19] Sensitivity The cases of prostatic adenocarcinoma were graded according to the Modified Gleason Grading System and the new ISUP/WHO classification 2014. [4] In the present study, Grade 4 and 5 (Gleason score 8 and 9) were most common, accounting for 56.39% of the malignant cases.…”

Section: Lack Of Follow Up Assessmentmentioning

confidence: 99%

Prostate - Specific Antigen, an Effective Screening Tool for Prostate Cancer - An Analysis of 932 TRUS Core Needle Biopsies

Lila

Chadha

Barodawala

2022

Int J Health Sci Res

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Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death among men in 2020. Since it is a slow growing tumour, an early detection leads to better chance of successful treatment. Prostate-Specific Antigen (PSA) is a protein found exclusively in prostatic tissue. It is elevated in different prostatic pathologies apart from carcinoma. A cohort of 932 prostatic core needle biopsies was selected after necessary exclusions. The routine haematoxylin & eosin and immunohistochemistry slides were retrieved along with the histopathologic diagnosis rendered. The diagnosis was then correlated with PSA. The mean age for diagnosis of prostatic disease and carcinoma was 68.39 years and 70.21 years respectively. 50.50% cases were premalignant or malignant whereas the remaining 49.50% cases were benign. A cut-off of 4 ng/ml had a sensitivity of 99.78% and a specificity of 7.33%. Gleason score 8 and 9 were most common, accounting for 56.39% of the malignant cases. The present study showed a statistical correlation of age and PSA with prostatic carcinoma. PSA is a valid and sensitive marker and may be continued as an early marker for the screening of prostate cancer. The risk of cancer is minimal with a PSA less than 4 ng/ml whereas an elevated PSA is associated with pathology and hence even a borderline elevation should not be ignored. Due to a low specificity, PSA needs to be corroborated with DRE and transrectal ultrasonography followed by biopsy in cases with PSA > 4ng/ml. Key words: Prostate, Prostate - Specific Antigen, Prostatic Adenocarcinoma, Benign Prostatic Hyperplasia.

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Correlation between prostate specific antigen, digital rectal examination and histology in patients with prostate cance

Cited by 3 publications

References 11 publications

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Sensitivity and specificity of prostate-specific antigen and its surrogates towards the detection of prostate cancer in sub-Saharan Africa: a systematic review with meta-analysis

Prostate - Specific Antigen, an Effective Screening Tool for Prostate Cancer - An Analysis of 932 TRUS Core Needle Biopsies

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