Correlation between Pulmonary Artery Pressure and Vortex Duration Determined by 4D Flow MRI in Main Pulmonary Artery in Patients with Suspicion of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Deux, Jean-François; Crowe, Lindsey A.; Genecand, Léon; Hachulla, Anne-Lise; Glessgen, Carl G; Noble, Stéphane; Beghetti, Maurice; Jin, Ning; Giese, Daniel; Lador, Frédéric; Vallée, Jean‐Paul

doi:10.3390/jcm11175237

Cited by 4 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The principle of this mathematical model could also be adapted to study the influence on the diagnosis of PcPH of different parameters of the PVR equation. For example, the mPAP can be estimated using cardiac magnetic resonance [ 17 ]. The mathematical model could be modified to study the diagnosis influence of the mPAP estimated using cardiac magnetic resonance compared to the mPAP measured during RHC.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Methods for Cardiac Output Determination on the Diagnosis of Precapillary Pulmonary Hypertension: A Mathematical Model

Genecand

Simian

Desponds

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

Background: precapillary pulmonary hypertension (PH, PcPH) is now defined as a mean pulmonary artery pressure (mPAP) > 20 mmHg, a pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg and a pulmonary vascular resistance (PVR) > 2 WU. For PVR calculation, the measurement of cardiac output (CO) is necessary. It is generally measured using thermodilution. However, recent data showed that the agreement with direct Fick method, historically the gold standard, is less than previously reported. We aimed to create a mathematical model that calculated the probability of being classified differently (PcPH or unclassified PH) if CO measured by direct Fick was used instead of thermodilution for any individual patients with a mPAP > 20 mmHg and a PAWP ≤ 15 mmHg. Methods: The model is based on Bland and Altman analysis with a normally distributed difference of cardiac output, fixed 1.96 standard deviation of bias, bias and physiological cardiac output limits. Results: Following a literature review of the studies comparing CO measured with direct Fick and thermodilution, we fixed the 1.96 standard deviation of bias at 2 L/min, bias at 0 L/min and physiological resting CO limits between 1.3 L/min and 10.2 L/min. Conclusions: This model can help the clinician to evaluate the potential benefit of measuring CO using direct Fick during the diagnostic work-up and its utility in confirming or ruling out a diagnosis of PcPH in any given patient with a mPAP > 20 mmHg and a PAWP ≤ 15 mmHg.

show abstract

Section: Discussionmentioning

confidence: 99%

The Influence of Methods for Cardiac Output Determination on the Diagnosis of Precapillary Pulmonary Hypertension: A Mathematical Model

Genecand

Simian

Desponds

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…This technique was made available by echocardiography, and its applicability and validity against CMR‐based technique is being currently studied. However, it is to be noted that the currently available Echocardiography‐derived software for vortex assessment is exclusively qualitative, not yet allowing the quantification of the observed vortices 7,8 …”

Section: Manuscriptmentioning

confidence: 99%

“…However, it is to be noted that the currently available Echocardiography-derived software for vortex assessment is exclusively qualitative, not yet allowing the quantification of the observed vortices. 7,8…”

Section: Why Pulmonary Hypertension Could Have Been Overlooked?mentioning

confidence: 99%

RSV‐induced LV dysfunction, what can be the underlying cause?

AbdelMassih

Ismail

Nabil

et al. 2022

Pediatric Pulmonology

View full text Add to dashboard Cite

“…However, this method is invasive, and transthoracic echocardiography is a favored method of detecting PHT probability. As a result, when PHT is suspected via echocardiography, further investigation such as cardiac magnetic resonance (CMR) help establish a definite diagnosis [7].…”

Section: Introductionmentioning

confidence: 99%

A plenary survey on the Incidence of cardiac complications amongst transfusion-dependent thalassemia patients

Bozorgi,

Khosropanah,

Haghpanah

et al. 2023

Acta Haematol Pol.

View full text Add to dashboard Cite

Introduction: Cardiac complications are the leading cause of mortality amongst transfusion-dependent thalassemia (TDT) patients. The multifactorial etiology of cardiac disorders makes their management challenging. Therefore, in addition to evaluating the incidence of heart failure (HF) and pulmonary hypertension (PHT), we assessed the associated factors among 737 TDT patients, aiming to achieve a plenary perspective of their cardiac disorders and relative factors. Material and methods:In this cross-sectional study, we evaluated the incidence of HF and PHT in 737 TDT patients while considering imperative factors such as endocrinopathies, iron status, and serum vitamin D level.Results: The incidence of total heart failure and pulmonary hypertension were estimated at 12.3% among participants, although the rate of cardiac iron overload was c.40%. Splenectomy, serum vitamin D, low bone mass, age, gender, hypoparathyroidism, hypogonadism, and diabetes significantly impaired the cardiac function of our patients. In univariate analysis, only the frequency of blood transfusion proved to have a risk effect on left ventricle ejection fraction.Conclusions: Cardiac iron overload has the highest impact on the incidence of cardiac disorders among TDT patients. We observed significant statistical associations between both HF and PHT with iron chelation regimen, endocrinopathies, splenectomy, serum vitamin D, and total body iron status in univariate analysis. Such results were not statistically significant in multiple logistic regression. However, in clinical practice, their effect could not be ignored. Further studies are required to achieve efficient management of thalassemia patients with cardiac disorders.

show abstract

Correlation between Pulmonary Artery Pressure and Vortex Duration Determined by 4D Flow MRI in Main Pulmonary Artery in Patients with Suspicion of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Cited by 4 publications

References 34 publications

The Influence of Methods for Cardiac Output Determination on the Diagnosis of Precapillary Pulmonary Hypertension: A Mathematical Model

The Influence of Methods for Cardiac Output Determination on the Diagnosis of Precapillary Pulmonary Hypertension: A Mathematical Model

RSV‐induced LV dysfunction, what can be the underlying cause?

A plenary survey on the Incidence of cardiac complications amongst transfusion-dependent thalassemia patients

Contact Info

Product

Resources

About