Correlation between rCBF, Angiography, EEG and Scanning in Brain Tumors

Hadjidimos, A.; Brock, M.; Haas, J.; Dietz, H.; Wolf, Rudolf; Ellger, M.; Fischer, Florian; Schürmann, K.

doi:10.1007/978-3-642-85860-4_63

Cited by 7 publications

(1 citation statement)

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“…In the grey matter changes of water and electrolytes were absent in both treated and untreated animals, confirming the previous notion that oedema was confined to peritumoural white matter alone (17,18). A well-known side-effect of oedema formation is the decrease of blood flow in the oedematous tissue (4,14,28,29,31). In the untreated group a decrease to about 60% from 32.2 to 18.9 ml/100 g/min was observed.…”

Section: Ill Resultsmentioning

confidence: 96%

Corticosteroid therapy of experimental tumour oedema

Matsuoka

Hossmann

1981

Neurosurg. Rev.

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Experimental brain tumours were produced in cats by stereotactic implantation of 4 million suspended cells of a rat glioma clone into the internal capsule. Three weeks after implantation a spherical tumour developed with a diameter of up to 10 mm which was surrounded by vasogenic white matter oedema. In untreated animals water content in the peritumoural white matter increased form 69.1 +/- 0.9 to 80.0 +/0 0.8 ml/100 g w. w., and regional blood flow reciprocally decreased from 32.2 +/- 5.6 to 18.9 +/- 0.05 ml/100 g/min. A single injection of a crystalline suspension of 10 mg/kg dexamethasone given intramuscularly one week before the animals were killed, led to a significant amelioration of brain oedema. Peritumoural white matter water content decreased to 73.0 +/- 0.5 ml/100 g w w. and blood flow rose to 35.7 +/- 2.8 ml/100 g/min. These changes were accompanied by parallel shifts of electrolyte content buy did not correlate with EEG activity, as assessed by Fourier frequency analysis. Corticosteroids did not prevent extravasation of peroxidase or Evans blue across the tumour vessels. The beneficial effect, therefore, is attributed to either an acceleration of resorption or an inhibition of the spread of oedema from tumour into the peritumoural brain tissue.

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Section: Ill Resultsmentioning

confidence: 96%

Corticosteroid therapy of experimental tumour oedema

Matsuoka

Hossmann

1981

Neurosurg. Rev.

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Permeability Characteristics of Brain Adjacent to Tumors in Rats

Levin¹,

Freeman-Dove²,

Landahl³

1975

Archives of Neurology

153

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The brain immediately surrounding 9L sarcoma and Walker 256 carcinosarcoma was evaluated, using radioactive water, albumin, red blood cells, urea, and sodium to quantitate isotopic exchange and permeability in the brain adjacent to tumor (BAT), normal brain, and, to a lesser extent, tumor. Exchange between blood and BAT for 14C-urea and 22Na averaged 53% of that for comparable regions of normal brain. This reduction in exchange is not explainable by differences in capillary surface area for transcapillary exchange in the BAT. This reduction in capillary permeability in the BAT could be detrimental to the delivery of watersoluble and rapidly binding drugs.

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