Correlation between Reading and Spelling Performance of Egyptian Children with Reading Disorder and their Cognitive and Linguistic Abilities

Nashaat, Neveen Hassan; Hasan, Haytham; Kilany, Ayman; Gebril, Ola H.; Helal, Suzette I.; Orabi, Ghada; Gaballah, Mostafa; Abdelraouf, Ehab R.

doi:10.1177/0973134220170202

Cited by 5 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the reading, writing, and other abilities involved in learning were found to be defective in the majority of participants. This is in agreement with previous reports investigating some cognitive abilities involved in learning, such as Elwan et al (2019) and Nashaat et al (2017), who reported the presence of deficits in some cognitive abilities in children with developmental dyslexia despite having normal ranges of intelligence quotients. Such deficits could be related to different brain activation and brain connectivity in areas involved in reading and phonological awareness tasks, such as temporoparietal and occipitotemporal areas.…”

Section: Discussionsupporting

confidence: 93%

BDNF Val66Met Polymorphism: Suggested Genetic Involvement in Some Children with Learning Disorder

et al. 2022

Self Cite

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal survival, especially in areas responsible for memory and learning. The BDNF Val66Met polymorphism has been described as a cognitive modifier in people with neuropsychiatric disorders. BDNF levels have been found to be low in children with learning disorder (LD). However, Val66Met polymorphism has not been studied before in such children. The aim was to investigate the presence of BDNF val66Met polymorphism in a group of children with specific LD and to verify its impact on their cognitive abilities. The participants in this cross-sectional study (N = 111) were divided into two groups: one for children with LD and the other for neurotypical (NT) ones. Children with LD (N = 72) were diagnosed according to the DSM-5 criteria. Their abilities were evaluated using Stanford–Binet Intelligence Scale, dyslexia assessment test, Illinois Test of Psycholinguistic Abilities, and phonological awareness test. Genotyping of BDNF Val66Met polymorphism was performed for all participants. The frequency of the Met allele was 26% among children with LD (6 children had homozygous, 26 had heterozygous genotype). The percentage of participants with deficits in reading, writing, and phonemic segmentation was higher in Met allele carriers when compared to non-Met allele carriers in LD group. The frequency of Met allele among NT children was 3.85% (0 homozygous, 3 children had heterozygous genotype) (p = 0.00001). The high frequency of Val66Met polymorphism among children with LD introduces the BDNF gene as a genetic modifier of learning performance in some children who manifest specific learning disorder (developmental dyslexia).

show abstract

Section: Discussionsupporting

confidence: 93%

BDNF Val66Met Polymorphism: Suggested Genetic Involvement in Some Children with Learning Disorder

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Balanced levels of these neurotransmitters are essential for appropriate brain function and adequate cognitive performance. The integrity of cognitive abilities is fundamental for proper learning, information processing, and executive functions fulfillment [ 29 ]. Furthermore, the KYN system has been hypothesized to impact the serotonin/melatonin system in the brain [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Kynurenine and oxidative stress in children having learning disorder with and without attention deficit hyperactivity disorder: possible role and involvement

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background The etiological and pathophysiological factors of learning disorder (LD) and attention deficit hyperactivity disorder (ADHD) are currently not well understood. These disorders disrupt some cognitive abilities. Identifying biomarkers for these disorders is a cornerstone to their proper management. Kynurenine (KYN) and oxidative stress markers have been reported to influence some cognitive abilities. Therefore, the aim was to measure the level of KYN and some oxidative stress indicators in children with LD with and without ADHD and to investigate their correlations with the abilities of children with LD. Methods The study included 154 participants who were divided into 3 groups: one for children who have LD (N = 69); another for children with LD and ADHD (N = 31); and a group for neurotypical (NT) children (N = 54). IQ testing, reading, writing, and other ability performance evaluation was performed for children with LD. Measuring plasma levels of KYN, malondialdehyde, glutathione peroxidase, and superoxide dismutase by enzyme-linked immunosorbent assay was performed for all participants. Results Some IQ measures and learning skills differed between the first two groups. The biochemical measures differed between children with LD (with and without ADHD) and NT children (p < 0.001). However, the biochemical measures did not show a significant statistical difference between the first two groups. KYN and glutathione peroxidase levels were correlated with one-minute writing and at-risk quotient, respectively (p = 0.03;0.04). KYN and malondialdehyde showed the highest sensitivity and specificity values. Conclusion These biochemical measures could be involved or have a role in the abilities’ performance of children with specific learning disorder.

show abstract

Correlation between diffusion tensor imaging measures and the reading and cognitive performance of Arabic readers: dyslexic children perspective

et al. 2020

View full text Add to dashboard Cite

Correlation between Reading and Spelling Performance of Egyptian Children with Reading Disorder and their Cognitive and Linguistic Abilities

Cited by 5 publications

References 22 publications

BDNF Val66Met Polymorphism: Suggested Genetic Involvement in Some Children with Learning Disorder

BDNF Val66Met Polymorphism: Suggested Genetic Involvement in Some Children with Learning Disorder

Kynurenine and oxidative stress in children having learning disorder with and without attention deficit hyperactivity disorder: possible role and involvement

Correlation between diffusion tensor imaging measures and the reading and cognitive performance of Arabic readers: dyslexic children perspective

Contact Info

Product

Resources

About