Correlation between Red Blood Cell Aggregation and Blood Glucose Level

Fukase, Akiyo; Nagasawa, Kanta; Mori, Shiro; Arakawa, Mototaka; Yashiro, Satoshi; Ishigaki, Yasushi; Kanai, Hiroshi

doi:10.1109/ultsym.2019.8926267

Cited by 5 publications

(7 citation statements)

References 8 publications

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“…Moreover, as the blood was not replenished, the various blood cells, in particular, the red blood cells, were continuously exposed to low glucose and oxygen environments. These conditions would have supported hemolysis [22], eryptosis [23], and aggregation [24], and further increases in blood viscosity with time. Such compounded increases in blood viscosity could have, in turn, supported renal artery stenosis and ischemia [25].…”

Section: Discussionmentioning

confidence: 99%

Modeling changes in vascular and extracellular matrix integrity that can occur in decellularized kidneys after implantation

Corridon

2021

Preprint

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A method was established to identify alterations in vascular patency and extracellular matrix integrity of decellularized porcine kidney scaffolds. These scaffolds were perfused with blood at physiologically normal (500 and 650 ml/min) and abnormal (200 ml/min) rates. Variations in venous outflow were then assessed over 24 hours. Angiographic data confirmed that standard arterial branching patterns and the integrity of the extracellular matrix were considerably disrupted. Scaffolds subjected to normal arterial perfusion rates observed drops in venous outflow across the 24 hours. These reductions rose from roughly 40% after 12 hours to 60% after 24 hours. At the end of the test period, regardless of the underlying damage that occurred, the kidneys appeared intact on the surface, and there were no apparent signs of clotting. In comparison, venous flow rates decreased by 80 to 100% across the 24 hours in acellular scaffolds subjected to a far lower perfusion rate of 200 ml/min. These kidneys also appeared intact after 24 hours of perfusion, but presented several arterial, venous, and ureteral clots. The results of this study provide insight into circumstances that limit scaffold viability and provide a simplified model to analyze other conditions that can better prepare scaffolds for long-term transplantation.

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Section: Discussionmentioning

confidence: 99%

Modeling changes in vascular and extracellular matrix integrity that can occur in decellularized kidneys after implantation

Corridon

2021

Preprint

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“…Therefore, in addition to the measurements at rest, the RF signals were measured under the condition of avascularization using crucible scissors. 35) The blood flow was stopped by pressing two points on the fingertip side and the heart side of the vein, as shown in Fig. 3(b), to prevent the backflow of the blood.…”

Section: Ultrafine Wires With Diameters { }mentioning

confidence: 99%

“…We have studied a noninvasive and quantitative method for measuring blood properties. [28][29][30][31][32][33][34][35][36][37] Saito et al assumed that RBCs aggregate as a single-sphere scatterer and estimated the size from the scattering characteristics extracted by normalizing the power spectrum measured from the vessel lumen with that from the rear wall using a focused ultrasound transducer. [28][29][30][31][32] We also examined the relationship between RBC aggregation using ultrasound and blood glucose level.…”

Section: Introductionmentioning

confidence: 99%

“…33,34) Fukase et al studied the relationship between the blood glucose levels and the brightness values of the B-mode image. 35) However, there are still problems, such as the low correlation between these parameters and the blood glucose levels and the lack of reproducibility of the results because of the variation in the data among the measurements. The development of a more accurate method for evaluating the degree of RBC aggregation would solve these problems.…”

Section: Introductionmentioning

confidence: 99%

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Estimation of aggregate size of red blood cell by introducing reference power spectrum measured for hemispherical ultrafine wire

Higashiyama

Mori

Arakawa

et al. 2022

Jpn. J. Appl. Phys.

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Noninvasive measurement of the degree of red blood cell (RBC) aggregation is useful for evaluating blood properties. In the present paper, we proposed a method to estimate the size of RBC aggregates without using the power spectrum of the posterior wall by introducing a reference scattering spectrum. The reference power spectra were calculated using the power spectrum measured for an ultrafine wire with a hemispherical tip. They were applied to the size estimation of microparticles simulating RBC aggregates. The estimated sizes were close to the true values, which shows that the calculated reference power spectra were suitable for accurate size estimation. The proposed method was also applied to in vivo measurements, and the estimated sizes between at rest and in RBCs aggregated by avascularization were successfully differentiated. This demonstrates that the proposed method will be useful for estimating the size of RBC aggregates.

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“…The realization of non-invasive and quantitative evaluation of blood properties will be useful for monitoring blood properties in patients in cases where blood sampling is difficult 23) and for checking blood glucose levels for daily treatment in diabetics. 24,25) Our previous studies have shown a positive correlation between the degree of RBC aggregation (the brightness of the B-mode image) and the blood glucose level, 26) but the precision of blood glucose level determination using ultrasound was low. One of the causes was considered to be the lack of ability to fix position in the elevation direction of the measurement target during the long-axis measurement.…”

mentioning

confidence: 99%

Stabilization of red blood cell aggregation evaluation using short-axis view of vein of ultrasound

Fukase

Higashiyama

Mori

et al. 2021

Jpn. J. Appl. Phys.

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Red blood cell (RBC) aggregation is the reversible adhesion of RBCs among themselves. We previously reported a positive correlation between blood glucose level and the degree of RBC aggregation (the brightness of the B-mode image). In the present study, we investigated the contribution to the brightness according to the deviation from the central axis in measurements along with the long-axis view of the vein. The results show that the brightness changed significantly for a slight change in the lateral position in the short-axis image. We found that the stability of the measurements was not guaranteed in the long-axis view and estimated the correct analysis window range for the short-axis view.

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Correlation between Red Blood Cell Aggregation and Blood Glucose Level

Cited by 5 publications

References 8 publications

Modeling changes in vascular and extracellular matrix integrity that can occur in decellularized kidneys after implantation

Modeling changes in vascular and extracellular matrix integrity that can occur in decellularized kidneys after implantation

Estimation of aggregate size of red blood cell by introducing reference power spectrum measured for hemispherical ultrafine wire

Stabilization of red blood cell aggregation evaluation using short-axis view of vein of ultrasound

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