Correlation between secretin-enhanced MRCP findings and histopathologic severity of chronic pancreatitis in a cat model

Zhang, Tingting; Wang, Li; Wang, Deng-bin; Huang, Zhijun; Li, Yuhua; Lü, Jianping

doi:10.1016/j.pan.2013.08.003

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Seven papers matched the inclusion criteria; however, only three of them were included in this review; two of them were excluded from the review for ethical reasons [ 6 , 7 ], one of them [ 8 ] did not include any details about MRI or MRCP protocol, and one was already a review.…”

Section: Resultsmentioning

confidence: 99%

Magnetic Resonance Imaging and Magnetic Resonance Imaging Cholangiopancreatography of the Pancreas in Small Animals

Briola

2022

Veterinary Sciences

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Magnetic resonance imaging (MRI) and MR cholangiopancreatography (MRCP) have emerged as non-invasive diagnostic techniques for the diagnosis of pancreatic and pancreatic duct disorders in humans. The number of studies focused on MR and MRCP for pancreatic disease in small animals is very limited. MR has been described for the evaluation of insulinoma in dogs and to investigate pancreatitis in cats. The studies were based on a standard protocol with T2 weighted (w) fast recovery fast spin-echo (FRFSE) with and without fat suppression, T1w FSE pre-contrast and T1w FSE post-contrast with and without fat suppression. MRCP after secretin stimulation has been described in cats to assess the pancreatic ductal system, taking advantage of pulse sequences heavily T2w as rapid acquisition with rapid enhancement (RARE), fast-recovery fast spin-echo (FRFSE) sequences and single-shot fast spin-echo (SSFSE) sequences. In addition to the standard protocol, fast spoiled gradient recalled echo pulse sequences (fSPGR) and volume interpolated 3D gradient-echo T1w pulse sequences pre and post-contrast have also been used in cats, reaching the goal of assessing the biliary tree and the pancreatic duct with the same sequence and in multiple planes. Despite the small amount of data, the results show potential, and the most recent technical innovations, in particular, focused on diffusion MRI and fast acquisition, further support the need for continued evaluation of MRI as an effective instrument for the investigation of pancreatic disease.

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Section: Resultsmentioning

confidence: 99%

Magnetic Resonance Imaging and Magnetic Resonance Imaging Cholangiopancreatography of the Pancreas in Small Animals

Briola

2022

Veterinary Sciences

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“…Regarding the correlation between MRCP and histological findings in CP, the usefulness of secretin‐enhanced MRCP (S‐MRCP) was assessed by Zhang et al. 20 Reportedly, S‐MRCP parameters are correlated with the histopathological severity of CP. Based on another report, Souza et al.…”

Section: Outline Of Progress In Diagnosing Cp By Eusmentioning

confidence: 99%

“…reported that EUS findings such as hyperechoic foci, hyperechoic strands, lobularity, and hyperechoic ductal margins are consistent with histological findings indicating fibrosis of the parenchyma, including focal fibrosis, bridging fibrosis, interlobular fibrosis and periductal fibrosis 8,12,18 (Table 1 and Figure 1). Regarding the correlation between MRCP and histological findings in CP, the usefulness of secretin‐enhanced MRCP (S‐MRCP) was assessed by Zhang et al 20 . Reportedly, S‐MRCP parameters are correlated with the histopathological severity of CP.…”

Section: Outline Of Progress In Diagnosing Cp By Eusmentioning

confidence: 99%

Diagnosing chronic pancreatitis by endoscopic ultrasound assessing the association between ultrasound and pathological findings: A narrative review

et al. 2022

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Endoscopic ultrasound (EUS) is widely recognized for its non‐invasiveness and for its usefulness in chronic pancreatitis (CP) diagnosis, including early CP. Although it is desirable to obtain a definitive diagnosis of CP by tissue sampling with EUS‐guided fine needle aspiration, histopathological changes in CP are heterogeneous in terms of the extent and the distribution of lesions. Therefore, histopathological diagnosis of appropriate tissue sampling by EUS‐fine needle aspiration is expected to be difficult. Furthermore, it is virtually impossible to match EUS images with pathological sections, making direct contrast between EUS findings and pathology difficult. This narrative review presents a discussion of the diagnosis of CP/early CP by EUS, particularly assessing the association between ultrasound and pathological findings. Recently, the histological corroboration and correlation of EUS findings related to CP have been clarified by surgical specimens, including those obtained from animal studies. Furthermore, remarkable advances have occurred in the objective and quantitative diagnosis of pancreatic fibrosis by EUS‐elastography. Future technological advances in EUS are expected to improve the accuracy of diagnosis of pancreatic fibrosis at earlier stages.

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“…The duct anatomy of the cat resembles the human pancreatic duct, as the single pancreatic duct joins the common bile duct before entering the duodenum (105). Blockage of the feline main pancreatic duct for CP induction was practiced in several studies by partial (106,107) and complete (108,109) duct ligation, well mimicking the major hallmarks of human CP (108). Information about visceral pain or intra-or extrapancreatic nerve alterations is not currently available for feline CP models.…”

Section: Nonrodent Models For Cpmentioning

confidence: 99%

Genetically inducedvs.classical animal models of chronic pancreatitis: a critical comparison

et al. 2018

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Chronic pancreatitis (CP) is an utmost complex disease that is pathogenetically linked to pancreas-intrinsic ( e.g., duct obstruction), environmental-toxic ( e.g., alcohol, smoking), and genetic factors. Studying such a complex disease naturally requires validated experimental models. In the past 2 decades, the various animal models of CP usually addressed either the pancreas-intrinsic ( e.g., the caerulein model), the environmental-toxic ( e.g., diet-induced models), or the genetic component of CP. As such, these models were far from mirroring CP in its full spectrum, and the correct choice of models was vital for valid scientific conclusions on CP. The quest for mechanistic, genetic models gave rise to models based on gene modification and transgene insertion, such as the PRSS1 and the IL-1β/IL-1β models. Recently, we witnessed the development of highly exciting models that rely on the importance of autophagy in CP, that is, the murine pancreas-specific Atg5 and LAMP2 knockout models. Today, critical comparison of these several models is more important than ever for guiding research on CP in an efficient direction. The present review outlines the characteristics of the new genetic models in comparison with the well-known classic models for CP, notes the caveats in the choice of models, and also indicates novel directions for model development.-Klauss, S., Schorn, S., Teller, S., Steenfadt, H., Friess, H., Ceyhan, G. O., Demir, I. K. Genetically induced vs. classical animal models of chronic pancreatitis: a critical comparison.

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Correlation between secretin-enhanced MRCP findings and histopathologic severity of chronic pancreatitis in a cat model

Cited by 5 publications

References 23 publications

Magnetic Resonance Imaging and Magnetic Resonance Imaging Cholangiopancreatography of the Pancreas in Small Animals

Magnetic Resonance Imaging and Magnetic Resonance Imaging Cholangiopancreatography of the Pancreas in Small Animals

Diagnosing chronic pancreatitis by endoscopic ultrasound assessing the association between ultrasound and pathological findings: A narrative review

Genetically inducedvs.classical animal models of chronic pancreatitis: a critical comparison

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