Correlation between Serum Enzymes and Serum Unsaturated
Vitamin B(12) Binding Proteins in Primary Liver Carcinoma

Osifo, Bola O.A.; Ayoola, A. A.; Parmentier, Yves; Gérard, P.; Nicolas, Jean‐Pierre

doi:10.1159/000469112

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…This phenomenon is im plicated in the regulation of the uptake of vitamin B12 in the cell. This could explain the decreasing levels of unsaturated TC II observed in MH by Osifo et al [8].…”

mentioning

confidence: 81%

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Blood Transcobalamin Levels in Malignant Hepatoma

Frémont¹,

Champigneulle²,

Gérard³

et al. 1991

Tumor Biol

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α-Fetoprotein (AFP) levels measured by RIA show a strong sensitivity for the biological diagnosis of malignant hepatoma (MH). However, this parameter lacks specificity. Previous observations of an alteration in vitamin B₁₂etabolism in the presence of hepatoma led us to study vitamin-B₁₂-binding proteins. Vitamin B₁₂, also called cobalamin, is transported in the blood by two proteins or transcobalamins: one is haptocorrin (HC), which is linked to most of the cobalamin, and the other is transcobalamin II, which is involved in tissue exchanges. In this work, the levels of AFP and transcobalamins were determined by RIA and radioisotope dilution assay, respectively. They were measured in patients with MH (group A) and in patients with other liver diseases (group B). Compared with group B, group A showed a significant increase in total serum HC (p < 0.005). In conclusion, it was observed that MH is accompanied by increased levels of HC. The origin of these changes could be due to either an increase in HC synthesis or a catabolic defect.

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“…This phenomenon is im plicated in the regulation of the uptake of vitamin B12 in the cell. This could explain the decreasing levels of unsaturated TC II observed in MH by Osifo et al [8].…”

mentioning

confidence: 81%

“…This rise could be induced by syn thesis of TC I by tumor cells [7], An increase in TC I and TC III can also be observed in viral hepatitis [8].…”

mentioning

confidence: 95%

Blood Transcobalamin Levels in Malignant Hepatoma

Frémont¹,

Champigneulle²,

Gérard³

et al. 1991

Tumor Biol

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show abstract

“…Several conditions that may result in elevated vitamin B 12 concentrations have been described, including immunological, inflammatory, infectious, hematologic and oncologic diseases [ 9 , 10 , 11 , 12 ]. Severe liver diseases, such as hepatitis, hepatocellular carcinoma and cirrhosis, were also found to be associated with elevated Cbl concentrations in blood [ 13 , 14 , 15 , 16 ]. A study conducted with 5571 participants in the Netherlands identified that higher concentrations of plasma vitamin B 12 (apparently reflecting some disorder) were associated with increased risk of all-cause mortality after adjusting for age, sex, and renal function among other variables [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Elevated Plasma Vitamin B12 in Patients with Hepatic Glycogen Storage Diseases

Hinkel

Schmitt

Wurm

et al. 2020

JCM

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Background: Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism affecting the synthesis or breakdown of glycogen in the liver. This study, for the first time, systematically assessed vitamin B12 status in a large cohort of hepatic GSD patients. Methods: Plasma vitamin B12, total plasma homocysteine (tHcy) and methylmalonic acid concentrations were measured in 44 patients with hepatic GSDs and compared to 42 healthy age- and gender-matched controls. Correlations of vitamin B12 status with different disease markers of GSDs (including liver transaminase activities and triglycerides) as well as the vitamin B12 intake were studied. Results: GSD patients had significantly higher plasma vitamin B12 concentrations than healthy controls (p = 0.0002). Plasma vitamin B12 concentration remained elevated in GSD patients irrespective of vitamin B12 intake. Plasma vitamin B12 concentrations correlated negatively with triglyceride levels, whereas no correlations were detected with liver transaminase activities (GOT and GPT) in GSD patients. Merging biomarker data of healthy controls and GSD patients showed a positive correlation between vitamin B12 status and liver function, which suggests complex biomarker associations. A combined analysis of biomarkers permitted a reliable clustering of healthy controls versus GSD patients. Conclusions: Elevated plasma concentration of vitamin B12 (irrespective of B12 intake) is a common finding in patients with hepatic GSD. The negative correlation of plasma vitamin B12 with triglyceride levels suggests an influence of metabolic control on the vitamin B12 status of GSD patients. Elevated vitamin B12 was not correlated with GOT and GPT in our cohort of GSD patients. Merging of data from healthy controls and GSD patients yielded positive correlations between these biomarkers. This apparent dichotomy highlights the intrinsic complexity of biomarker associations and argues against generalizations of liver disease and elevated vitamin B12 in blood. Further studies are needed to determine whether the identified associations are causal or coincidental, and the possible impact of chronically elevated vitamin B12 on GSD.

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Iron Deficiency and Megaloblastic Anemias

Solomon¹

1992

Biochemical Pharmacology of Blood and Bloodforming Organs

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Correlation between Serum Enzymes and Serum Unsaturated Vitamin B(12) Binding Proteins in Primary Liver Carcinoma

Cited by 7 publications

References 12 publications

Blood Transcobalamin Levels in Malignant Hepatoma

Blood Transcobalamin Levels in Malignant Hepatoma

Elevated Plasma Vitamin B12 in Patients with Hepatic Glycogen Storage Diseases

Iron Deficiency and Megaloblastic Anemias

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