Correlation between serum ferritin and glycaemic control in patients of type 2 diabetes mellitus: a case control study

Maheshwari, Amitkumar; Bhoi, Bharat K.; Sadariya, Bhavesh; Javia, Hardik N; Gusani, Jigar; Sharma, Hunny

doi:10.18203/2320-6012.ijrms20150625

Cited by 9 publications

(7 citation statements)

References 4 publications

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“…These results go with the result of [20]. On the other hand, increased accumulation of iron affects insulin synthesis and its secretion from the pancreas and interferes with the insulin-extracting capacity of the liver.…”

Section: Study the Correlation Analysis Correlation Coefficient (R) Bsupporting

confidence: 71%

Study the Biochemical Correlation of Insulin Resistance with HbA1c and Sex Hormones in NIDDM Patients/Meisan-Iraq

Al–Fartosy¹,

Mohammed²

2017

JDM

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Objective: The association between type 2 diabetes mellitus and certain endocrine disorders has the paucity of information and limited data in the province of Meisan (southern of Iraq). Hence, in the present study, an attempt was made to investigate the levels of plasma HbA1c, serum insulin resistance and levels of serum sex hormones in men and women of control and type 2 diabetic patients. Also, the present study aimed to explored the correlation coefficient (r) between insulin resistance and level of HbA1c, FSH, LH, Tt, progesterone and estradiol in men and women patients with NIDDM. Methods: One hundred Iraqi volunteers with abdominal obesity were selected in the present study. Fifty diabetic patients with NIDDM (26 men, and 24 women) aged between (37) and (65) years and 50 healthy individuals (25 men, and 25 women) aged between (36) and (65) years considered as control group. Complete medical history was taken from each subject and complete clinical examinations were performed for all volunteers. Then, the two groups were matched for their fasting blood sugar, BMI, insulin hormone; c-peptide, HbA1c, sex hormones and insulin resistance parameters (HOMA2-IR, HOMA%B and HOMA%S) were calculated using HOMA2 calculator software. Results: We found that insulin resistance demonstrated negative correlations (p < 0.05) with levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, progesterone and estradiol. While, there was a positive and significant correlation (p < 0.01) with value of HbA1c in men and women NIDDM patients. Conclusion: We conclude that an increase in the level of insulin resistance is associated with increased level of blood HbA1c and decreased in level of serum sex hormones (FSH, LH, Tt, E2 and progesterone) in men and women of diabetic group. These behaviors might suggest that insulin resistance can be used as a potential biomarker for predicting dysfunction of sex hygiene in NIDDM patients in addition to glycemic control.

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Section: Study the Correlation Analysis Correlation Coefficient (R) Bsupporting

confidence: 71%

Study the Biochemical Correlation of Insulin Resistance with HbA1c and Sex Hormones in NIDDM Patients/Meisan-Iraq

Al–Fartosy¹,

Mohammed²

2017

JDM

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“…Serum ferritin is an acute phase reactant and a marker of iron stores in the body. Some previous studies have reported significantly higher ferritin levels in patients with DM compared to controls [ 43 , 44 ]. Age-related changes in some of the physiological functions in elderly with DM such as alteration in gastric acidity may increase their risk of iron deficiency iron [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Malnutrition in elderly patients with type 2 diabetes mellitus in a Nigerian tertiary hospital: A cross-sectional study

Junaid

Ojo

Adejumo

et al. 2022

Dialogues in Health

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“…Elevated iron concentrations cause tissue and organ damage. 13,14 Increased iron accumulation impacts insulin synthesis, its discharge from pancreas, and the capability of liver for absorbing insulin. A consequence of muscle injury, iron buildup in muscles decreases glucose uptake.…”

Section: Discussionmentioning

confidence: 99%

Influence of serum ferritin on glycemic control in patients with type 2 diabetes mellitus.

Sughandh Memon,

Bhagwan Das,

Noor un Nisa

et al. 2024

TPMJ

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Objective: To determine the influence of serum ferritin levels on glycemic control in patients with type 2 diabetes mellitus (T2DM) patients. Study Design: Cross-sectional study. Setting: Department of Medicine, Liaquat University Hospital, Hyderabad, Pakistan. Period: July 2021 to December 2021. Material & Methods: A total of 180 patients of 30-60 years of age and either gender, and known cases of diabetes mellitus for ≥3 year duration were included. Demographic, clinical and laboratory data was recorded. HbA1c below 7% was labeled as good glycemic control while HbA1c above or equal to 7% was designated as poor glycemic control. The serum ferritin ≥307 μg/L was considered as raised. Association of glycemic control with respect to serum ferritin levels was noted. Results: In a total of 180 patients of T2DM, the mean age, duration of diabetes, and HbA1c were 53.62 ± 5.82 years, 11.91±4.92 years, and 12.41 ± 5.73% respectively. The mean serum ferritin was 512±22.53 ug/L, whereas serum ferritin was raised in 109 (60.5%). The serum ferritin levels were significantly higher in patients with poor glycemic control than those having good glycemic control (56.0% versus 44.0%, p=0.044). Conclusion: In contrast to individuals with good glycemic control, patients with poor glycemic control more frequently had elevated serum ferritin levels, according to the current study. In order to properly manage diabetes patients and prevent the negative effects of elevated serum ferritin levels, serum ferritin should be included in the usual screening protocol of diabetic patients while monitoring their glycemic status.

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Correlation between serum ferritin and glycaemic control in patients of type 2 diabetes mellitus: a case control study

Cited by 9 publications

References 4 publications

Study the Biochemical Correlation of Insulin Resistance with HbA1c and Sex Hormones in NIDDM Patients/Meisan-Iraq

Study the Biochemical Correlation of Insulin Resistance with HbA1c and Sex Hormones in NIDDM Patients/Meisan-Iraq

Malnutrition in elderly patients with type 2 diabetes mellitus in a Nigerian tertiary hospital: A cross-sectional study

Influence of serum ferritin on glycemic control in patients with type 2 diabetes mellitus.

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