2023
DOI: 10.1136/gpsych-2023-101009
|View full text |Cite
|
Sign up to set email alerts
|

Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study

Abstract: BackgroundThe correlation between cognitive function and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides, is inconsistent.AimsThis cross-sectional study investigated the association between serum lipid levels and the prevalence of cognitive impairment among community-dwelling older adults and explored this difference in association by gender and urban-rural residency.MethodsParticipants aged 65 and above in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

1
2
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(4 citation statements)
references
References 43 publications
1
2
0
Order By: Relevance
“…Particularly, the average response time, a key neuropsychological measure, exhibited distinct clinical correlates within each task. Our findings regarding the associations between average response time and lipid profile (including total cholesterol) in Code Substitution task were in line with prior studies that have explored the relationship between cholesterol levels and cognitive function ( 36 , 37 ). Notably, higher total cholesterol levels have been linked to cognitive impairment, emphasizing the importance of cardiovascular health in cognitive outcomes.…”
Section: Discussionsupporting
confidence: 90%
“…Particularly, the average response time, a key neuropsychological measure, exhibited distinct clinical correlates within each task. Our findings regarding the associations between average response time and lipid profile (including total cholesterol) in Code Substitution task were in line with prior studies that have explored the relationship between cholesterol levels and cognitive function ( 36 , 37 ). Notably, higher total cholesterol levels have been linked to cognitive impairment, emphasizing the importance of cardiovascular health in cognitive outcomes.…”
Section: Discussionsupporting
confidence: 90%
“…Specifically, McFarlane et al found higher levels of total cholesterol and LDL in MCI compared to controls [28]. In addition, Lee et al proposed HDL as a protective factor against cognitive impairment; also, triglycerides were proposed by Yu et al as a protective factor but only for men, while LDL levels were a protective factor for women [27,29]. Wood et al found higher levels of DAG 34:2 and DAG 36:2 and lower levels of PlsE 40:6 in MCI and early onset AD patients with low scores for MMSE [31].…”
Section: Discussionmentioning
confidence: 99%
“…Among them, cholesterol or triglycerides are the most studied lipids in serum [26,27]. In general, higher levels have been related to cognitive decline risk [27], and they have been evaluated in case-control studies [28] or in normal elderly populations [27,29]. Specifically, McFarlane et al found higher levels of total cholesterol and low-density lipoprotein (LDL) in mild cognitive impairment (MCI) than in cognitive normal and dementia groups, suggesting an increase and then the restorage of basal levels [28], while high-density lipoprotein (HDL) could be considered as a protective factor against cognitive impairment [27].…”
Section: Introductionmentioning
confidence: 99%
“…With the largest ageing population in the world, China is faced with the huge challenge of dementia. [1][2][3][4] However, previously reported estimates on the prevalence of dementia among Chinese older adults were inconsistent, varying from 2% to 13%. 5 6 It is crucial for dementia prevention to determine the number of cases that could be delayed or prevented, but how to do this remains unclear.…”
Section: Introductionmentioning
confidence: 99%