Correlation between Serum Retinol and .ALPHA.-Tocopherol Levels in Centenarians

Basile, Giorgio; Gangemi, Sebastiano; Balbo, Claudia Lo; Mento, Antonella; Nicita-Mauro, Claudio; Crisafulli, G.; Merendino, Rosaria Alba; Ientile, Riccardo; Nicita-Mauro, Vittorio

doi:10.3177/jnsv.49.287

Cited by 13 publications

(5 citation statements)

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“…dl-a-tocopherol and all-trans-retinol in serum showed a correlation coefficient of 0.268 (p,0.0001), confirming the findings of other studies [134,135]. Both were also correlated with MDA, strengthening their protective role in terms of lipid peroxidation-induced damage [108,136,137].…”

supporting

confidence: 91%

Selenium and vitamin status in the Al‐Kharj district, Saudi Arabia

MPhil

El‐Doush

Billedo

et al. 2005

Journal of Nutritional & Environmental Medicine

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Purpose. To determine the status of selenium, dl-a-tocopherol and all-trans-retinol in children and adults living in the Al-Kharj district, using serum and toenail samples. Design. A cross-sectional study. The samples were collected randomly from 1255 healthy Saudi subjects attending the Primary Health Care Units (PHCUs), Al-Kharj for different common health problems. Materials and methods. Serum and toenail selenium concentrations were measured using an atomic absorption spectrophotometer coupled with an electrothermal temperature controller, whereas the levels of dl-a-tocopherol, all-trans-retinol and malondialdehyde in serum were determined using highperformance liquid chromatography. Results. The arithmetic means of selenium, dl-a-tocopherol and all-trans-retinol in serum for the tested population were 102.165¡22.936 mg l 21 (n51255, range 18.25-210.12 mg l 21 ), 22.715¡6.908 mmol l 21 (n51250, range 2.53-79.44 mmol l 21 ) and 1.601¡0.802 mmol l 21 (n51256, range 0.39-13.99 mmol l 21 ), respectively. Toenail selenium levels were 0.613¡0.217 mg g 21 (n51069, range ,detection limit-1.797 mg g 21 ).Conclusions. The prevalence of subjects with serum selenium below the threshold limit of clinical importance in coronary and cardiovascular diseases (45 mg l 21 ) was only 0.56%, whereas 45.4% of the tested subjects had toenail selenium ,0.56 mg g 21 , a low level, as indicated in a previous study. There was an influence of the geographical location of the PHCU on selenium levels, reflecting different dietary habits. To confirm this finding, it would be useful to study selenium dietary intake. dl-atocopherol deficiency (,11.6 mmol l 21 ) was found in only 2.6% of the screened subjects, suggesting sufficient vitamin E intake. However, none of the participants in this study had a severe all-transretinol deficiency (,0.35 mmol l 21 ) and the percentage of participants with marginal deficiency ,0.7 mmol l 21 was only 3.2%. The present data provide support that the dietary habits among the different PHCUs studied are adequate regarding all-trans-retinol nutritional requirements. Malondialdehyde as a marker of lipid peroxidation was evaluated and a significant negative association between dl-a-tocopherol and malondialdehyde levels in the serum was found, confirming the role of vitamin E in reducing oxidative stress.

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supporting

confidence: 91%

Selenium and vitamin status in the Al‐Kharj district, Saudi Arabia

MPhil

El‐Doush

Billedo

et al. 2005

Journal of Nutritional & Environmental Medicine

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“…This, in turn, may promote unremitting inflammatory and/or autoimmune processes negatively correlated with human longevity (Zanni et al ., 2003). Indeed, vitamin A levels are consistently elevated in healthy centenarians, suggesting a protective role in immune system maintenance by retinoids (Mecocci et al ., 2000; Basile et al ., 2003; Franceschi and Bonafe, 2003; Polidori et al ., 2007). According to this, a large body of experimental studies have suggested several molecular mechanisms underlying the beneficial effects of retinoids in immune system disorders.…”

Section: Retinoids Act As Immunomodulatorsmentioning

confidence: 99%

Retinoids: novel immunomodulators and tumour‐suppressive agents?

Carratù

Marasco

Mangialardi

et al. 2012

British J Pharmacology

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Retinoids play important roles in the transcriptional activity of normal, degenerative and tumour cells. Retinoid analogues may be promising therapeutic agents for the treatment of immune disorders as different as type I diabetes and systemic lupus erythematosus. In addition, the use of retinoids in cancer treatment has progressed significantly in the last two decades; thus, numerous retinoid compounds have been synthesized and tested. In this paper, the actual or potential use of retinoids as immunomodulators or tumour‐suppressive agents is discussed.

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“…Nutrition related factors that have been explored in centenarians include low energy intakes (3), antioxidant status (4–6), and cardiovascular diseases in centenarians and their offspring (7–10). We reported in a population-based study of centenarians that the prevalence of vitamin D deficiency was 8.9% (< 25 nmol/L 25-hydroxyvitamin D) and of vitamin D insufficiency was 36.7% (< 50 nmol/L) (2).…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia

Johnson

Hausman

Davey

et al. 2010

The Journal of nutrition, health and aging

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Objective-Test the hypotheses that vitamin B12 deficiency would be prevalent in octogenarians and centenarians and associated with age, gender, race/ethnicity, living arrangements (community or skilled nursing facility), animal food intake, B-vitamin supplement use, atrophic gastritis, folate status, and hematological indicators.Design-Population-based multi-ethnic sample of adults aged 80 to 89 and 98 and above. Setting-Northern Georgia in the United States.Participants-Men and women aged 80 to 89 (octogenarians, n = 80) and 98 and older (centenarians, n = 231).Measurements-Wilcoxon signed-rank tests, Fisher's exact tests, and logistic regression analysis was used to examine the associations of vitamin B12 status with the variables of interest.Results-After excluding participants receiving vitamin B12 injections (n = 17), the prevalence of vitamin B12 deficiency was higher in centenarians than in octogenarians (35.3% vs. 22.8%, p < 0.05, defined as plasma vitamin B12 < 258 pmol/L and serum methylmalonic acid > 271 nmol/L and methylmalonic acid > serum 2-methylcitrate) and in both age groups was correlated with significantly higher homocysteine (p < 0.05) and lower plasma and red cell folate (p < 0.01), but was not related to hemoglobin, anemia, mean cell volume, or macrocytosis. In logistic regression analysis, the probability of being vitamin B12-deficient was significantly increased by being a centenarian vs. Two of the authors (SPS and RHA) and the University of Colorado hold patents on the use of assays for total homocysteine and other metabolites to diagnose vitamin B12 and folate deficiencies, and a company has been formed at the University of Colorado to perform such assays.

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Correlation between Serum Retinol and .ALPHA.-Tocopherol Levels in Centenarians

Abstract: Recent evidence indicates that longevity may be achieved when efficient defence mechanisms against oxidative stress, infections, neoplasia, and cardiovascular events are preserved. Centenarians represent an example of "successful aging," and the aim

Cited by 13 publications

References 4 publications

Selenium and vitamin status in the Al‐Kharj district, Saudi Arabia

Selenium and vitamin status in the Al‐Kharj district, Saudi Arabia

Retinoids: novel immunomodulators and tumour‐suppressive agents?

Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia

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