Correlation between Serum Uric Acid Level and Left Ventricular Ejection Fraction in Patients with Congestive Heart Failure

Ezzat, Mohamed Abdel Wahab; Boghdady, Ahmed; Ibrahim, Kassem F. A.; Dahab, Lotfy H. Abo

doi:10.4236/wjcd.2019.911076

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The interaction between liver and heart diseases is predictable. There is a close interconnectedness between them, and the reason is that the liver receives 25% of the blood pumped by the heart 22 and not only cardiovascular system is damaged by heart failure in the long term but the damage is done to the rest of the body organs and various tissues 23,24 . In a study conducted by the researcher (15), it has been intended to create a relationship between EF and liver function in patients who have heart failure, by which it is concluded that the levels of ALP, ALT and AST en-zymes are elevated in patients' serum who have an average ejection fraction ≤ 40% and lower levels in patients with an average ejection fraction > 40%.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ejection fraction in patients with Acute Myocardial Infarction in Mosul City, Iraq

Al-Nafoly

AL-Ameen

Alshamaa

2022

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Between 1 January 2021 and 1 July 2021, 120 blood samples from acute myocardial infarction (AMI) patients—60 as controls and 60 patients—of both sexes who were accepted to the cardiac surgery unit at AL- Salam teaching hospital, the intensive cardiac care unit, and outpatient clinics in Mosul City/Iraq, were taken. In the presented research, the ejection fraction regarding patients with AMI was evaluated by echocardiography, and the blood-liver enzyme levels (ALP and AST \ ALT ratio) were examined in those patients. The findings indicate that patients with AMI in the age range of 35 to 45 years have a (52.41) % ejection fraction (EF) rate, which is closer to (51.344%) than it is in samples from healthy controls. In addition to that, findings indicate that patients in an age range of 46 to 56 years have heart failure with a mid-range EF (HFmrEF), with a (48.13%) percentage, whereas this heart failure type in healthy controls has been preserved ejection fraction (HFpEF) with (53.368 %). In the case of the comparison of the AST/ALT ratio and EF across all of the age groups that have been tested, the results suggest a significant level (P ≤ 0.050) relation between the ALP enzyme and EF for the patients within the (35-45 years) age group additionally, as there has been a positive and weak linear connection (r = 0.10650) and a nominal p-value (p = 0.47240) at a threshold of probability ≤ P 0.050, the link and correlation between the AST/ALT ratio and cardiac EF have been investigated. Keywords: ALP enzyme, AMI patients, Ejection Fraction, AST \ ALT ratio.

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Section: Discussionmentioning

confidence: 99%

Evaluation of ejection fraction in patients with Acute Myocardial Infarction in Mosul City, Iraq

Al-Nafoly

AL-Ameen

Alshamaa

2022

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Association of serum uric acid with left ventricular ejection fraction: A retrospective insight from a tertiary care hospital of North East India

Gupta,

Boro,

Paul

et al. 2023

Heart India

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Context: Cardiometabolic risk factors play crucial roles in left ventricular dysfunctions (left ventricular failure): a defining feature of heart failure (HF) with preserved ejection fractions (HFpEF). Among the many, serum uric acid (SUA) is a controversial risk factor that needs to be investigated globally. Aim: We aim to elucidate a correlation of SUA with ejection fraction percentage (EF%) in patients with chronic HF supporting the probable notion of hyperuricemia being a prognostic biomarker. Settings and Design: This retrospective, cohort study was performed on patients who visited from January 2022 to June 2022 in the Department of Cardiology at a tertiary care hospital in Northeastern India. Methods: A series of 81 selected patients with known congestive HF were documented with various baseline, clinical, and biochemical parameters. Patients were divided into three groups based on EF% and their relation with SUA, along with other parameters was analyzed. Statistical Analysis: Data were presented as mean ± standard deviation and frequencies for continuous variables and categorical variables, respectively. ANOVA one-way tests were conducted for continuous variables and Chi-square tests for categorical variables. P< 0.05 was considered as statistically significant. Results: A significant correlation was established between levels of SUA and EF (P = 0.021). Hence, hyperuricemia is directly related to an increased risk of lower EF. Conclusion: Even when asymptomatic, SUA can be used as a prognostic biomarker in the assessment of HF diseases.

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Correlation between Serum Uric Acid Level and Left Ventricular Ejection Fraction in Patients with Congestive Heart Failure

Cited by 2 publications

References 7 publications

Evaluation of ejection fraction in patients with Acute Myocardial Infarction in Mosul City, Iraq

Evaluation of ejection fraction in patients with Acute Myocardial Infarction in Mosul City, Iraq

Association of serum uric acid with left ventricular ejection fraction: A retrospective insight from a tertiary care hospital of North East India

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