Correlation between Serum Uric Acid Level and Microalbuminuria in Type-2 Diabetic Nephropathy

Latif, Hina; Iqbal, Atif; Rathore, Rabia; Butt, Nasir Farooq

doi:10.12669/pjms.336.13224

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…Therefore, UA levels are associated with the occurrence and development of DN and are independent risk factors for early kidney disease [72, 73], which help to predict microalbuminuria progression [74]. Serum UA and microalbuminuria levels were significantly positively correlated with renal disease in patients with T2DM [75]. Patients with higher SUA levels have poorer renal function, independent of glycated hemoglobin (HbA1c) or the duration of diabetes [76].…”

Section: Epidemiology Studiesmentioning

confidence: 99%

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Xiong

Liu

2019

International Journal of Endocrinology

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With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.

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Section: Epidemiology Studiesmentioning

confidence: 99%

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Xiong

Liu

2019

International Journal of Endocrinology

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“…Several studies have reported [29] that fenofibrate could inhibit the renal organic anion transporter urate transporter 1 and increase urinary excretion of UA to decrease serum UA levels. Several studies [30][31][32] have shown that serum UA and microalbuminuria are significantly positively associated in T2DM patients.…”

Section: Discussionmentioning

confidence: 99%

Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

2020

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Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia. Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n = 28) and the control group (n = 28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment. Results: After 180 days, the reduction of level of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) between two groups showed no difference. In the treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [− 44.05(− 179.47, − 12.16) vs − 8.15(− 59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG (r = 0.447, P = 0.042) and UA (r = 0.478, P = 0.024) after fenofibrate treatment. Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate.

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“…Many diabetes complications appear with the progress of disease and correlated with the duration of disease including coronary artery diseases, nephropathy, retinopathy, and neuropathy (Kobayashi et al 2020). As the duration of disease prolonged, the serum level of many biomarkers including uric and microalbuminuria (Latif et al 2017) indicating the progression of nephropathy with time. Therefore, this is a good point to consider CLNK as a predictor for a complication that needs more investigation.…”

Section: Discussionmentioning

confidence: 99%

Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus

Al-Fadhel

Al-Ghuraibawi

Ali

et al. 2020

Preprint

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Type 2 diabetes mellitus (T2DM) is an endocrine illness associate with various changes in the immune system and adaptor protein levels. Cytokine dependent hematopoietic cell linker (CLNK) is an adapter protein that regulates immune receptor signaling and acts as a regulator of the receptor signaling of T-cells and natural killer T-cell. The role of CLNK in T2DM is not studied previously. In the present study, serum CLNK level was measured and correlated with some sociodemographic and insulin resistance (IR) parameters. This is achieved by performing measurement of CLNK and insulin parameters (glucose, insulin, and HbA1c in addition to the calculation of the functions of IR (HOMA2IR), insulin sensitivity (HOMA%S), and beta-cell function (HOMA%B)) in 60 T2DM patients and 30 controls. The results indicated a significant increase (p=0.025) in serum CLNK in patients group in comparison with the controls. Multivariate generalized linear model (GLM) analysis revealed no significant effect of age, BMI, and sex on the CLNK level. The results of tests for between-subjects showed that the CLNK affects diagnosis significantly (F=7.445, p=0.008, partial η2 =0.081) and its effect is approximately the same as the effect of insulin (F=8.107, p=0.006, partial η2 =0.087). The correlation study showed a highly significant positive correlation between CLNK and the duration of disease (rho=0.420, p<0.001). It can be concluded that the increase CLNK in T2DM revealing the role of the adaptor proteins level in the nature of disease. Elevation of CLNK level may be used as a predictor for diabetes complications, which needs more investigations.

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Correlation between Serum Uric Acid Level and Microalbuminuria in Type-2 Diabetic Nephropathy

Cited by 15 publications

References 21 publications

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus

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