Correlation between sleep and cognitive functions after hemispheric ischaemic stroke

Siccoli, Massimiliano M.; Rölli-Baumeler, N.; Achermann, Peter; Bassetti, C.

doi:10.1111/j.1468-1331.2008.02119.x

Cited by 53 publications

(44 citation statements)

References 34 publications

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“…In their study, Schuiling et al (2005) found that sleep fragmentation was one of the most frequent findings in patients with hemorrhagic stroke. Siccoli et al (2008) analyzed continuous night waking and reported longer wake duration during sleep time in the acute stage when compared to the subacute and chronic stages of the disease. Seitz et al (2011) found that some patients in the acute stage after middle cerebral artery stroke show a secondary decline in general motor activity related to an enhanced sleep demand.…”

Section: Discussionmentioning

confidence: 98%

Actigraphic Analysis of the Sleep–Wake Cycle and Physical Activity Level in Patients with Stroke: Implications for Clinical Practice

Cavalcanti

Campos

Araújo

2012

Chronobiology International

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Several structures of the central nervous system are essential in the sleep-wake regulation process. This study aimed to identify which actigraphic parameters of the sleep-wake cycle (SWC) are compromised after stroke and determine whether low-level physical activity can influence the expression of sleep-cycle temporal variation, in order to discuss the implications for the clinical practice of patient rehabilitation. The study assessed 22 patients (55 ± 12 years) and 24 healthy individuals (57 ± 11 years), of both sexes. The instruments used were the International Physical Activity Questionnaire (IPAQ) and Actigraphy. Data were analyzed by the student t, Mann-Whitney, and Spearman's correlation tests. Patients' activity level was about 28% lower than that of healthy subjects. Furthermore, we recorded around 10% more activity in the sleep phase compared to the controls, indicating that patients suffer from fragmented sleep (p < .001). According to IPAQ classification, we observed that healthy individuals were classified more predominantly as active (66.7%) and patients as irregularly active B (72.8%). A significant correlation was found between IPAQ and total activity (R= -.25; p= .007) and sleep latency (R= .27; p= .0006). In conclusion, the results obtained show a decrease in activity intensity in the SWC and significant sleep alterations related to greater duration, latency, and fragmentation. It is suggested that, in addition to motor impairments, sleep disorder complaints should be given priority during clinical diagnosis of patients with stroke.

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Section: Discussionmentioning

confidence: 98%

Actigraphic Analysis of the Sleep–Wake Cycle and Physical Activity Level in Patients with Stroke: Implications for Clinical Practice

Cavalcanti

Campos

Araújo

2012

Chronobiology International

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“…These results suggest that this increase of non-REM sleep at 2 days is not related to SD intervention but rather to an effect of the SD as the preconditioning effect that should be clarified in the future. Indeed, there are studies at supporting the fact that non-REM sleep is a good predictor of favourable outcomes after hemispheric ischemia [17, 18]. …”

Section: Discussionmentioning

confidence: 99%

Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia

et al. 2017

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Study ObjectivesSleep reduction after stroke is linked to poor recovery in patients. Conversely, a neuroprotective effect is observed in animals subjected to acute sleep deprivation (SD) before ischemia. This neuroprotection is associated with an increase of the sleep, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) systems. This study aims to 1) assess the relationship between sleep and recovery; 2) test the association between MCH and OX systems with the pathological mechanisms of stroke.MethodsSprague-Dawley rats were assigned to four experimental groups: (i) SD_IS: SD performed before ischemia; (ii) IS: ischemia; (iii) SD_Sham: SD performed before sham surgery; (iv) Sham: sham surgery. EEG and EMG were recorded. The time-course of the MCH and OX gene expression was measured at 4, 12, 24 hours and 3, 4, 7 days following ischemic surgery by qRT-PCR.ResultsA reduction of infarct volume was observed in the SD_IS group, which correlated with an increase of REM sleep observed during the acute phase of stroke. Conversely, the IS group showed a reduction of REM sleep. Furthermore, ischemia induces an increase of MCH and OX systems during the acute phase of stroke, although, both systems were still increased for a long period of time only in the SD_IS group.ConclusionsOur data indicates that REM sleep may be involved in the neuroprotective effect of SD pre-ischemia, and that both MCH and OX systems were increased during the acute phase of stroke. Future studies should assess the role of REM sleep as a prognostic marker, and test MCH and OXA agonists as new treatment options in the acute phase of stroke.

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“…De acordo com a literatura, pacientes com um único evento isquê-mico mostraram uma correlação entre o desempenho da memória verbal e não verbal com a quantidade de sono de ondas lentas, sono REM e eficiência do sono, sugerindo uma ligação entre o sono e as funções cognitivas após o AVE 14,15 . Assim, a investigação de problemas relacionados ao sono é um importante componente da abordagem diagnóstica e terapêutica clínica.…”

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Cronotipo e implicações para sua utilização na fisioterapia em pacientes com acidente vascular encefálico

Campos

Pinheiro²,

Diógenes³

et al. 2011

Fisioter. Pesqui.

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ABStRAct:In clinical practice, the physical therapist often evaluates and programs the patient's treatment without taking into account the temporal variation of functions and behaviors. The aim of this study was to analyze the influence of the chronotype (morning type -evening type), sleep-wake state (sleep quality and excessive sleepiness) and lifestyle regularity in determining the preferred time of day for physical and mental activities following stroke. Participants responded to the MorningnessEveningness Questionnaire (MEQ), the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS) and the Social Rhythm Metric (SRM). The subjects were asked at what time of day they preferred to perform physical (exercises) and mental (tasks of reasoning) activities, considering only their well-being. A total of 42 patients (61±9 years) in the chronic stage after stroke (18±21 months) and 12 healthy individuals took part in the study. The data were analyzed using the χ 2 test and multiple regression. Among the patients evaluated, 64% had poor sleep quality, 43% excessive sleepiness and 57% an irregular daily routine. Regression analysis showed that chronotype was the only factor studied that influenced the preferred time of day for the activities. The results indicate the need for the physical therapist to analyze how chronotype can affect patient performance before establishing time of day of the physical therapy sessions.

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Correlation between sleep and cognitive functions after hemispheric ischaemic stroke

Cited by 53 publications

References 34 publications

Actigraphic Analysis of the Sleep–Wake Cycle and Physical Activity Level in Patients with Stroke: Implications for Clinical Practice

Actigraphic Analysis of the Sleep–Wake Cycle and Physical Activity Level in Patients with Stroke: Implications for Clinical Practice

Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia

Cronotipo e implicações para sua utilização na fisioterapia em pacientes com acidente vascular encefálico

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