Correlation between small intestinal bacterial overgrowth and irritable bowel syndrome and the prognosis of treatment

Yu, Xuelian; Li, Yue; Xiang, Feng; Feng, Jingjuan

doi:10.21037/apm-21-427

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…In the same study, increased IL-1β level was predominantly associated with bloating and loose stools (Bristol type 6). In a recent study, also on patients with IBS, IL-1β levels in the peripheral blood were higher in the SIBO positive group compared to the SIBO negative group [ 21 ]. IL-1β levels decreased significantly after antibiotic treatment strengthening the hypothesis of SIBO’s contribution to elevated IL-1β.…”

Section: Discussionmentioning

confidence: 99%

Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study

et al. 2022

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Small intestinal bacterial overgrowth (SIBO) contributes to the formation of an inflammatory environment in various intestinal and extraintestinal diseases. Cytokines that participate in these mechanisms are yet to be examined. Upper gastrointestinal endoscopy with duodenal aspiration was performed in 224 patients. Quantitative cultures of aerobic species were performed, concentrations of interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) were measured, and loads of Escherichia coli, Klebsiella pneumoniae, Methanobevibacter smithii, and Aeromonas spp. were detected via real-time PCR in the duodenal fluid. Analysis showed that the odds ratio (OR) for elevated IL-1β levels was 2.61 (1.06–6.43, p = 0.037) among patients with SIBO compared to patients without SIBO, while there was no significant difference at elevated IL-6 and TNF-α levels between patients with and without SIBO, using ≥10³ cfu/mL as a cut-off. The presence of all three elevated cytokine levels has OR 3.47 (1.06–11.34, p = 0.030) among patients with SIBO. Klebsiella pneumoniae detection was positively related with IL-6 and TNF-α levels, when Methanobevibacter smithii was positively related with IL-1β levels. The presence of SIBO is associated with elevated IL-1β levels in the duodenal fluid. There is a high prevalence of all three proinflammatory cytokine levels elevated (IL-1β, IL-6, and TNF-α) in the duodenal fluid among patients with SIBO.

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Section: Discussionmentioning

confidence: 99%

Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study

et al. 2022

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“…Irritable bowel syndrome (IBS) is the most common functional digestive disorder. In developed countries, its prevalence varies between 10% and 15% [56,57]. It is estimated that the incidence of bacterial proliferation of the small intestine in patients with IBS was 51.7% compared to healthy subjects -16.7%.…”

Section: Irritable Bowel Syndrome (Ibs)mentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Diseases Related- Current State of Knowledge

Roszkowska,

Klimczak,

Ostrycharz

et al. 2024

Preprint

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“…Serum interleukin (IL)-1β levels were higher and serum IL-10 levels were lower in SIBO-positive patients with IBS than in the SIBO-negative group[ 32 ]. Another study also showed that increased IL-1α and IL-1β levels were associated with SIBO[ 33 ].…”

Section: Functional Digestive Diseasesmentioning

confidence: 99%

Epidemiology of small intestinal bacterial overgrowth

Efremova,

Maslennikov,

Poluektova

et al. 2023

World J Gastroenterol

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Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the bacterial content of the small intestine above normal values. The presence of SIBO is detected in 33.8% of patients with gastroenterological complaints who underwent a breath test, and is significantly associated with smoking, bloating, abdominal pain, and anemia. Proton pump inhibitor therapy is a significant risk factor for SIBO. The risk of SIBO increases with age and does not depend on gender or race. SIBO complicates the course of a number of diseases and may be of pathogenetic significance in the development of their symptoms. SIBO is significantly associated with functional dyspepsia, irritable bowel syndrome, functional abdominal bloating, functional constipation, functional diarrhea, short bowel syndrome, chronic intestinal pseudo-obstruction, lactase deficiency, diverticular and celiac diseases, ulcerative colitis, Crohn’s disease, cirrhosis, metabolic-associated fatty liver disease (MAFLD), primary biliary cholangitis, gastroparesis, pancreatitis, cystic fibrosis, gallstone disease, diabetes, hypothyroidism, hyperlipidemia, acromegaly, multiple sclerosis, autism, Parkinson’s disease, systemic sclerosis, spondylarthropathy, fibromyalgia, asthma, heart failure, and other diseases. The development of SIBO is often associated with a slowdown in orocecal transit time that decreases the normal clearance of bacteria from the small intestine. The slowdown of this transit may be due to motor dysfunction of the intestine in diseases of the gut, autonomic diabetic polyneuropathy, and portal hypertension, or a decrease in the motor-stimulating influence of thyroid hormones. In a number of diseases, including cirrhosis, MAFLD, diabetes, and pancreatitis, an association was found between disease severity and the presence of SIBO. Further work on the effect of SIBO eradication on the condition and prognosis of patients with various diseases is required.

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Correlation between small intestinal bacterial overgrowth and irritable bowel syndrome and the prognosis of treatment

Cited by 8 publications

References 18 publications

Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study

Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study

Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Diseases Related- Current State of Knowledge

Epidemiology of small intestinal bacterial overgrowth

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