Correlation Between Suicide Rate and Antidepressant Use in Slovenia

Oravecz, Robert; Czigler, Bala ́zs; Leskosˇek, Franc

doi:10.1080/13811110301555

Cited by 15 publications

(13 citation statements)

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“…However, the overlapping 95% CIs indicate statistical nonsuperiority for the 1990s versus 1980s. Moreover, when 11 studies [41][42][43][44]46,47,[49][50][51]53,58 reporting changes in total annual suicide rates for both decades were compared directly (Table 2), the average decrease in suicide rates in the 1980s was by −9.98% (95% CI, −15.7% to −4.3%) compared to −10.7% (95% CI, −18.0% to −3.4%) in the 1990s-again, not statistically different. Decreases in suicide rates were found in both men and women in the 1990s, but were 4.4-times greater than in the 1980s among men (−14.4% vs. −3.31%), but only slightly greater among women (−19.7% vs. −16.9%) in the more recent decade.…”

Section: Resultsmentioning

confidence: 93%

“…40,45,46,58 We considered possible explanations for this variability by use of regression modeling (not presented here). Changes neither in antidepressant availability nor in suicide rates in the 1990s were correlated with the year of publication, population of the country involved, or number or types of units of measurement (years, countries, or counties).…”

Section: Resultsmentioning

confidence: 99%

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Ecological Studies of Antidepressant Treatment and Suicidal Risks

Baldessarini

Tondo

Dominguez

et al. 2007

Harvard Review of Psychiatry

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Ongoing discussion of potential benefits and risks of antidepressant treatment with respect to suicidal behaviors includes many ecological, or population-based, correlational studies of temporal or regional trends in suicide rates and rates of usage of modern antidepressants including serotonin-reuptake inhibitors (SRIs). Since this body of research has not been compiled and evaluated, we used computerized literature searching to identify 19 relevant published studies. They yielded heterogeneous findings: only 8/19 found significant inverse correlations between rising sales of modern antidepressants in the 1990 s and falling suicide rates not anticipated in the 1980s. Average reductions in suicide rates in the 1990 s (10.7%) and 1980s (10.0%) differed little in 11 studies with data from both eras. Reduction of suicide rates in the 1990 s was unrelated to geographic region, population size, units of analysis, publication year, or growth in antidepressant usage, but was greater with higher initial suicide rates, in men, and in older persons. In the same decade, suicides rates decreased in only half of 79 large countries. Overall, these findings yield limited and inconsistent support for the hypothesis that increased use of modern antidepressants might limit suicide risk, and no evidence that the risk increased. Suicidal risk is determined by complex factors, including access to clinical services, in general, and more comprehensive treatment of depression, in particular. Overall, as with findings from randomized trials and cohort or case-control studies, evidence of specific antisuicidal effects of antidepressant treatment from ecological analyses remains elusive.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Ecological Studies of Antidepressant Treatment and Suicidal Risks

Baldessarini

Tondo

Dominguez

et al. 2007

Harvard Review of Psychiatry

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“…The three negative studies came from Iceland, Northern Ireland and Slovenia (18)(19)(20), with annual number of suicides of about 30, 150 and 600 respectively. The three negative studies came from Iceland, Northern Ireland and Slovenia (18)(19)(20), with annual number of suicides of about 30, 150 and 600 respectively.…”

Section: Antidepressant Use and Suicide Preventionmentioning

confidence: 99%

Antidepressant use and suicide prevention: a prescription database study in the region Friuli Venezia Giulia, Italy

Castelpietra¹,

Morsanutto²,

Pascolo-Fabrici³

et al. 2008

Acta Psychiatr Scand

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“…In the absence of clear evidence from clinical trials, researchers have investigated whether rises in antidepressant prescribing are associated with reductions in population suicide rates 2 – 6 17 – 19. With some exceptions,3 17 18 such studies conclude that recent rises in prescribing have contributed to falls in suicides.…”

Section: Time Trendsmentioning

confidence: 99%

“…With some exceptions,3 17 18 such studies conclude that recent rises in prescribing have contributed to falls in suicides. Interpretation of these findings is not straightforward.…”

Section: Time Trendsmentioning

confidence: 99%