Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee

Sharif, Mohammed; George, Emmanuel; Dieppe, Paul

doi:10.1002/art.1780380112

Cited by 81 publications

(39 citation statements)

References 16 publications

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“…reported to be higher in synovial fluid from patients with severe scintigraphic signals compared with that from patients with mild alterations on knee scans (39). Unlike patients with osteoporosis, OA patients tend to have a high body mass index together with an elevated rate of bone turnover, resulting in increased bone density (40).…”

Section: Discussionmentioning

confidence: 99%

Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse

Watters¹,

Cheng²,

Pickarski³

et al. 2007

Arthritis & Rheumatism

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Objective. The biologic changes associated with osteoarthritis (OA) are incompletely understood. The aim of this study was to elucidate the molecular mechanisms underlying OA progression in an STR/Ort murine model of spontaneous disease.Methods. Global patterns of gene expression were assessed using microarray analysis of articular cartilage/subchondral bone from the tibial plateaus of STR/Ort mice at 3, 9, and 12 months of age. The age-dependent severity of osteophyte formation and extent of cartilage damage were determined in the corresponding femurs using microfocal computed tomography and the Mankin histologic scoring system. Pathway analysis was used to identify the functions of genes associated with OA progression, and changes in gene expression were confirmed using immunohistochemistry.Results. Six hundred twenty-one genes were associated with both osteophyte formation and cartilage damage in the STR/Ort joints. Genes involved in the development/function of connective tissue and in lipid metabolism were most significantly enriched and regulated during disease progression. Genes directly interacting with peroxisome proliferator-activated receptor ␣ (PPAR␣)/PPAR␥ were down-regulated, whereas those genes involved with connective tissue remodeling were up-regulated during disease progression. Associations of down-regulation of myotubularinrelated phosphatase 1 (a phosphoinositide 3-phosphatase involved in lipid signaling) and up-regulation of biglycan (a member of the small leucine-rich protein family known to modulate osteoblast differentiation and matrix mineralization) with OA progression were confirmed by immunohistochemistry.Conclusion. Since adipogenesis and osteogenesis are inversely related in the developing skeletal tissue, these results suggest that a shift in the differentiation of mesenchymal cells from adipogenesis toward osteogenesis is a component of the OA pathophysiologic processes occurring in the tibial plateau joints of STR/Ort mice.

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Section: Discussionmentioning

confidence: 99%

Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse

Watters¹,

Cheng²,

Pickarski³

et al. 2007

Arthritis & Rheumatism

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“…In the ACL dog model of OA, Brandt et al [6] reported that, at a later stage of the disease, 54 months after OA induction, there was a marked increase in the volume of subchondral bone with active bone formation. Studies in OA of the knee and the hand reported that the scintigraphic abnormalities correlated with the osteocalcin concentration in the synovial fluid, which is a marker of bone formation, and serum osteopontin, a bone matrix protein, were also elevated [21][22][23]. Gevers and Dequeker also showed elevated serum osteocalcin levels in women with hand OA, and elevated osteocalcin in cortical bone explants [24].…”

Section: Correlation Between In Vivo Findings In Animals and Human Oamentioning

confidence: 96%

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Tat

Lajeunesse

Pelletier

et al. 2010

Best Practice & Research Clinical Rheumatology

156

121

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Over the past few decades, significant progress has been made with respect to new concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the knowledge we have today on the involvement of the subchondral bone in OA. It provides substantial evidence that changes in the metabolism of the subchondral bone are an integral part of the OA disease process and that these alterations are not merely secondary manifestations, but are part of a more active component of the disease. Thus, a strong rationale exists for therapeutic approaches that target subchondral bone resorption and/or formation, and data evaluating the drugs targeting bone remodelling raise the hope that new treatment options for OA may become available.

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“…[18] However, some other studies suggest that markers of bone turnover are not increased. [19,20] The level of bone markers may not necessarily imply increased bone turnover as restructuring of the bone in question is local. It is already known that biochemical markers indicating bone turnover may differ with the timing of sampling, osteoporosis, menopausal state, age, and several diseases.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis

Demircioğlu

2011

Turk J Rheumatol

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Amaç: Bu çalışmada semptomatik diz osteoartriti (OA) olan hastalarda kemiğe özgü serum alkalen fosfataz düzeyi ile fonksiyonel durum arasındaki ilişki araştırıldı. Bulgular: Kemiğe özgü alkalen fosfataz değeri, hasta grubunda ortalama 13.69±4.76 mg/dl idi. Kemiğe özgü alkalen fosfataz değerleri açısından kontrol grubu ile hasta grubu arasında istatistiksel olarak anlamlı bir fark bulunmadı (p= 0.584). Hastaların %28.5'inde kemik yapım hızı yüksek idi. Kemiğe özgü alkalen fosfataz ile WOMAC tutukluk skoru arasında ise anlamlı pozitif korelasyon bulundu (p= 0.07, r= 0.340). Kemiğe özgü alkalen fosfataz ile ağrı, fiziksel fonksiyon, WOMAC total skoru ve Lequesne indeksi arasında anlamlı korelasyon bulunmadı (sırasıyla, p= 0.590, r= 0.090, p= 0.489, r= 0.107, p= 0.413, r= 0.139, p= 0.285 r= 0.70). Hastalar ve yöntemler:Sonuç: Bu çalışmada semptomatik diz osteoartriti olan hastaların yaklaşık 1 /4'ünde kemik yapım hızında artış olduğu gösterilmiştir. Kemik yapım hızı ile dizdeki tutukluk arasında anlamlı bir pozitif ilişki bulunmuştur. Ancak hastalık şiddeti ile karşılaştırıldığında kemik yapım hızı, ağrı ve fiziksel fonksiyon arasında herhangi bir ilişki gözlemlenmemiştir.Anahtar sözcükler: Diz; osteoartrit; osteogenez.Objectives: This study aims to investigate the relationship between serum levels of bone-specific alkaline phosphatase and functional status in patients with symptomatic knee osteoarthritis (OA). Patients and methods:Seventy patients (57 females, 13 males; mean age 57.5±9.3 years; range 48 to 67 years) diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria and 30 age-and gender-matched healthy controls (mean age 56.4±7.5 years) were enrolled in the study. Patients were evaluated using clinical, laboratory and radiographic methods. Bone-specific alkaline phosphatase and 24-hour urinary calcium and phosphorus levels were tested to assess bone metabolism. The Lequesne index was used for the severity of disease and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used for the functional status. Results:The mean bone-specific alkaline phosphatase value was 13.69±4.76 mg/dl in the patient group. No statistically significant difference was found between the patient group and the control group in terms of bone-specific alkaline phosphatase values (p=0.584). The bone formation rate was high in 28.5% of the patients. A significantly positive correlation was found between the bone-specific alkaline phosphatase and the WOMAC stiffness scores (p=0.07, r=0.340). No significant correlation was found between the bone-specific alkaline phosphatase and the pain, physical function, and the total scores of the WOMAC and Lequesne index (p=0.590, r=0.090, p= 0.489, r= 0.107, p= 0.413, r= 0.139, p= 0.285, r= 0.70 respectively). Conclusion:In this study, an increase was shown in the bone formation rate in approximately 1 /4 of the patients with symptomatic knee osteoarthritis. A significant positive correlation was found between bone formation rate and knee stiffness...

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Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee

Cited by 81 publications

References 16 publications

Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse

Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis

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