Satellite data and a 35-year hindcast of the Amundsen Sea Embayment summer climate using the Weather Research and Forecasting model are used to understand how regional and large-scale atmospheric variability affects thinning of ice shelves in this sector of West Antarctica by melting from above and below (linked to intrusions of warm water caused by anomalous westerlies over the continental shelf edge). El Niño episodes are associated with an increase in surface melt but do not have a statistically significant impact on westerly winds over the continental shelf edge. The location of the Amundsen Sea Low and the polarity of the Southern Annular Mode (SAM) have negligible impact on surface melting, although a positive SAM and eastward shift of the Amundsen Sea Low cause anomalous westerlies over the continental shelf edge. The projected future increase in El Niño episodes and positive SAM could therefore increase the risk of disintegration of West Antarctic ice shelves.Plain Language Summary Most of the floating ice shelves fringing the Amundsen Sea Embayment (ASE) region of West Antarctica have undergone rapid thinning by basal melting in recent decades, resulting in upstream acceleration of grounded ice and raising global sea levels. Recent climate model projections suggest an intensification of austral summer melt over the ASE ice shelves by the end of the century due to increasing summer air temperatures to magnitudes that caused the recent breakup of ice shelves in Antarctic Peninsula. However, so far, the effect of regional and large-scale atmospheric variability on summertime thinning of ASE ice shelves has not been quantified in a spatially explicit manner. Here we employ a high-resolution regional model and satellite data to show that the location of Amundsen Sea Low, the polarity of Southern Annular Mode, and the phase of El Niño-Southern Oscillation are responsible for pronounced changes in the zonal wind stress over the ASE continental shelf edge and temperatures above the melting point over ASE ice shelves. Particularly, El Niño events are associated with enhanced surface melting over Pine Island and Thwaites Glaciers. The projected future increase in El Niño episodes could therefore increase the risk of disintegration of ASE ice shelves.