Correlation Between Systolic Deformation and Dyssynchrony Indices and the Grade of Left Ventricular Hypertrophy in Hypertensive Patients With a Preserved Systolic Ejection Fraction Undergoing Coronary Angiography, Based on Tissue Doppler Imaging

Zoroufian, Arezou; Razmi, T Muhammed; Savand-Roomi, Zahra; Lotfi‐Tokaldany, Masoumeh; Sadeghian, Hakimeh; Sahebjam, Mohammad; Jalali, Arash

doi:10.7863/ultra.33.1.119

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…This decreased LV synchrony could be attributed to increased sodium retention and high blood pressure. Indeed, some studies have shown that hypertension causes LV remodeling and alters myocardial electrophysiological properties, such as increased cardiomyocyte autorhythmicity and potential instability, myocardial electrophysiological conduction block, and myocardial excitation-contraction coupling dysregulation, all of which may lead to impaired LV systolic synchrony [37,38]. Due to excessive volume overload, elevated peripheral blood pressure, and lack of ATP, LV contraction time is extended as a compensatory mechanism to insure adequate cardiac output [39].…”

Section: Discussionmentioning

confidence: 99%

Layer-specific speckle tracking analysis of left ventricular systolic function and synchrony in maintenance hemodialysis patients

Liu

Yan

Fan

et al. 2020

BMC Cardiovasc Disord

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Background: This study investigated the value of layer-specific strain analysis by two-dimensional speckle tracking echocardiography (2D-STE) for evaluating left ventricular (LV) systolic function and synchrony in maintenance hemodialysis (MHD) patients. Methods: A total of 34 MHD patients and 35 healthy controls were enrolled in this study. Dynamic images were collected at the LV apical long-axis, the four-and two-chamber, and the LV short-axis views at the basal, middle, and apical segments. The layer-specific speckle tracking (LST) technique was used to analyze the longitudinal strain (LS) and circumferential strain (CS) of LV sub-endocardium, mid-myocardium, sub-epicardium, global longitudinal strain (GLS), global circumferential strain (GCS), the LV 17 segment time to peak LS (TTP), and the peak strain dispersion (PSD). The differences in these parameters were compared between control and MHD groups, and the correlation between PSD and each LS parameter was examined. The receiver operator characteristic (ROC) curve was used to evaluate the efficacy of three myocardial layer LS and CS in the assessment of LV systolic dysfunction in MHD patients. Results: MHD patients had comparable left ventricular ejection fraction (LVEF), but significantly smaller LV GLS, GCS, and three-layer LS and CS compared to the control group. The three myocardial layer LS of the basal segment, middle segment, and apex segment was significantly reduced in the MHD patients compared to the normal subjects, while the three myocardial layer CS of the basal segment, middle segment, and apex segment was significantly reduced in the MHD patients compared to the normal subjects, except for the sub-endocardium of the middle and apex segment. MHD patients had significantly higher TTP of LV 17 segments and PSD compared to controls, and had delayed peak time in most segments. In addition, PSD of MHD patients was positively correlated with sub-endocardial and mid-myocardial LS and GLS, but not with sub-epicardial LS. The area under the curves (AUCs) of sub-endocardial, mid-myocardial, and sub-epicardial LS in MHD patients were 0.894, 0.852, and 0.870, respectively; the AUCs of sub-epicardial, mid-myocardial, and sub-endocardial CS were 0.852, 0.837, and 0.669, respectively. Conclusions: LST may detect early changes of all three-layer LS and CS and PSD in MHD patients, and is therefore a valuable tool to diagnose LV systolic dysfunction in MHD patients.

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Section: Discussionmentioning

confidence: 99%

Layer-specific speckle tracking analysis of left ventricular systolic function and synchrony in maintenance hemodialysis patients

Liu

Yan

Fan

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…This decreased LV synchrony could be attributed to increased sodium retention and high blood pressure. Indeed, some studies have shown that hypertension causes LV remodeling and alters myocardial electrophysiological properties, such as increased cardiomyocyte autorhythmicity and potential instability, myocardial electrophysiological conduction block, and myocardial excitation-contraction coupling dysregulation, all of which may lead to impaired LV systolic synchrony (37)(38). Due to excessive volume overload, elevated peripheral blood pressure, and lack of ATP, LV contraction time is extended as a compensatory mechanism to insure adequate cardiac output (39).…”

Section: Discussionmentioning

confidence: 99%

Layer-specific speckle tracking analysis of left ventricular systolic function and synchrony in maintenance hemodialysis patients

Liu

Fan

Huang

et al. 2019

Preprint

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Background: This study investigated the value of layer-specific strain analysis by twodimensional speckle tracking echocardiography (2D-STE) for evaluating left ventricular (LV) systolic function and synchrony in maintenance hemodialysis (MHD) patients. Methods: A total of 34 MHD patients and 35 healthy controls were enrolled in this study. Dynamic images were collected at the LV apical long-axis, the four- and twochamber, and the LV short-axis views at the basal, middle, apical segments. The layerspecific speckle tracking (LST) was used to analyze the longitudinal strain (LS) and circumferential strain (CS) of LV sub-endocardium, mid-myocardium, subepicardium, global longitudinal strain (GLS), global circumferential strain (GCS), the LV 17 segment time to peak LS (TTP), the peak strain dispersion (PSD). The differences in these parameters were compared between control and MHD, and the correlation between PSD and each LS parameter was examined. The receiver operator characteristic curve was used to evaluate the efficacy of three myocardial layer LS and CS in the assessment of LV systolic dysfunction in MHD. Results: MHD had comparable left ventricular ejection fraction (LVEF), but significantly smaller GLS, GCS, and three-layer LS and CS compared to the control. The three layer LS of the basal segment, middle segment, and apex segment was significantly reduced in the MHD compared to the normal, while the three myocardial layer CS of the basal segment, middle segment, and apex segment was significantly reduced in the MHD compared to the normal, except for the sub-endocardium of middle and apex segment. MHD had significantly higher TTP of LV 17 segments and PSD compared to controls, and had delayed peak time in most segments. In addition, PSD of MHD was positively correlated with subendocardial and mid-myocardial LS and GLS, but not with subepicardial LS. The area under the curves (AUCs) of sub-endocardial, mid-myocardial, and sub-epicardial LS in MHD were 0.894, 0.852, and 0.870, respectively; the AUCs of sub-epicardial, midmyocardial, and sub-endocardial CS were 0.852, 0.837, and 0.669, respectively. Conclusion: LST may detect the early changes of all three-layer LS and CS and PSD in MHD, and is a valuable tool to diagnose LV systolic dysfunction in MHD.

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“…Therefore, accurate assessment of cardiac function should be combined with the coordination and synchronization of myocardium mechanical movement. The newly developed PSD index combines the myocardial deformation and whether the deformation of 17 myocardial segments is uniform in the LV 10,12 . The above two factors were combined to evaluate LV systolic function.…”

Section: Discussionmentioning

confidence: 99%

“…The emerging study of peak strain dispersion (PSD) identifies whether the peak time of long axis strain of LV myocardium is consistent, which can directly reflect the effective work of the heart and make up for the deficiency of GLS in evaluating LV systolic function [10][11][12] . PSD is used to evaluate the early systolic dysfunction of LV by combining the coordination and synchronization of cardiac mechanical movement, and this index has been applied to assess early LV systolic dysfunction in some diseases, such as mitral valve prolapse 13 , aortic stenosis 14…”

Section: Value Of Peak Strain Dispersion In Discovering Left Ventricumentioning

confidence: 99%

Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus

Miao

et al. 2020

Sci Rep

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Cardiovascular disease is one of the main causes of death in diabetes mellitus (DM) patients. The aim of the current study was to explore the value of peak strain dispersion (PSD) for discovering early-stage left ventricular (LV) dysfunction in type 2 diabetes mellitus (T2DM) patients. One hundred and one T2DM patients and sixty healthy subjects were selected for this study. T2DM patients were further divided into controlled blood glucose (HbA1c < 7%, n = 46) and uncontrolled blood glucose (HbA1c ≥ 7%, n = 55) subgroups. All participants underwent conventional echocardiography and two-dimensional speckle-tracking echocardiography. Our results showed that an obvious difference was not observed in global longitudinal strain (GLS) between the controlled blood glucose group and the control group (− 20.34% vs − 21.22%, P = 0.068). Compared with the healthy controls, the uncontrolled blood glucose group showed an impaired GLS (− 18.62% vs − 21.22%, P < 0.001). Nevertheless, PSD was appreciably increased in the controlled blood glucose group (36.02 ms vs 32.48 ms, P = 0.01) and uncontrolled blood glucose group (57.51 ms vs 32.48 ms, P < 0.001). Multivariate linear regression analysis showed that HbA1c was closely related to PSD lesion in the LV in the T2DM group (β = 0.520, P < 0.001). PSD plays an important role in evaluating the coordination and synchronization of myocardial movement and provides a more accurate and sensitive index assessment of early LV systolic function in T2DM patients. In addition, HbA1c levels were related to LV dysfunction.

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Correlation Between Systolic Deformation and Dyssynchrony Indices and the Grade of Left Ventricular Hypertrophy in Hypertensive Patients With a Preserved Systolic Ejection Fraction Undergoing Coronary Angiography, Based on Tissue Doppler Imaging

Cited by 10 publications

References 26 publications

Layer-specific speckle tracking analysis of left ventricular systolic function and synchrony in maintenance hemodialysis patients

Layer-specific speckle tracking analysis of left ventricular systolic function and synchrony in maintenance hemodialysis patients

Layer-specific speckle tracking analysis of left ventricular systolic function and synchrony in maintenance hemodialysis patients

Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus

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