Correlation between the degree of contrast enhancement and the volume of peritumoral edema in meningiomas and malignant gliomas

Holodny, Andrei I.; Nusbaum, Annette O.; Festa, Steven; Pronin, Igor; Lee, H. J.; Kalnin, Andrew

doi:10.1007/s002340050848

Cited by 44 publications

(18 citation statements)

References 28 publications

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“…A correlation between contrast enhancement and peritumoral edema, indicating similar mechanisms, namely breakdown of the blood-brain barrier for both phenomena, could be established for glioma but not for meningioma [27]. A physical barrier in certain meningiomas might limit propagation of edema into the adjacent white matter.…”

Section: Edema Associated With Tumor Histology and Grade And Therapy-mentioning

confidence: 91%

Brain Edema in Neurooncology: Radiological Assessment and Management

Wick

Küker

2004

Oncol Res Treat

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Vasogenic brain edema is a common diagnostic and management problem in brain tumor patients. Molecular mechanisms play a role in the pathophysiology, including abnormalities of tumor endothelium, vascular endothelial growth factor and leukotriene synthase. Edema diagnosis is facilitated by the development of neuroradiological imaging techniques, with diffusion-weighted imaging (DW-MRI) differentiating tumor grades or abscesses and tumors, and diffusion tensor imaging representing an advanced technique to potentially differentiate malignant glioma from metastasis or facilitate preoperative planning. Edema is a prognostic factor for meningioma and metastases but not for glioma. Therapy includes, amongst others, tumor-directed measures such as debulking surgery, radio- and chemotherapy. However, local therapeutic approaches might also induce or exacerbate edema formation. Peritumoral edema can usually be managed with corticosteroids. However, patients on corticosteroids are at greater risk of metabolic changes, Pneumocystis carinii pneumonia, and thromboembolism. More recently, inhibitors of cyclooxygenase-2 as well as boswellic acids have been explored as antiedema agents in patients with brain tumors.

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Section: Edema Associated With Tumor Histology and Grade And Therapy-mentioning

confidence: 91%

Brain Edema in Neurooncology: Radiological Assessment and Management

Wick

Küker

2004

Oncol Res Treat

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“…The explanation may be that BOLD response is inherently a vascular phenomenon, which is marginally affected by tumor size (18,27). However, this should be interpreted with caution, as the exact determination of tumor volumes at routine MR imaging is difficult in gliomas, in which borders are often ill defined (30). The lack of an effect of tumor distance to the PMC may also be supported by the aforementioned studies that demonstrated neurovascular uncoupling past the radiologic borders of the tumors (4,28,31).…”

Section: Neuroradiology: Influence Of Tumor Type and Bold Functional mentioning

confidence: 99%

Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus

Abreu¹,

Peck²,

Petrovich-Brennan³

et al. 2016

Radiology

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Purpose:To evaluate the effects of histologic features and anatomic magnetic resonance (MR) imaging characteristics of brain tumors on the functional MR imaging signal in the primary motor cortex (PMC), as false-negative blood oxygen leveldependent (BOLD) functional MR imaging activation can limit the accurate localization of eloquent cortices. Materials andMethods:Institutional review board approval was obtained, and informed consent was waived for this HIPAA-compliant retrospective study. Conclusion:BOLD functional MR imaging activation in the ipsilateral PMC is influenced by tumor type and is significantly reduced in GBMs. FLAIR abnormality correlates moderately with the activation ratios in metastases and meningiomas.q RSNA, 2016

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“…The findings offer indirect radiological evidence that the defect in the BBB which causes edema is etiologically related to the defect in BBB responsible for contrast enhancement 7 . Significant correlation can be found (p=0.0006) between the volume of peritumoural edema and the degree of contrast enhancement in gliomas 8 .…”

Section: Discussionmentioning

confidence: 86%

MRI of Diffusely Infiltrating Intracranial Astrocytomas: Association between the Volume of Peritumoural Edema and the degree of Contrast Enhancement

Khan

Rahman

et al. 2013

Bangla. J. Neuroscience

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Introduction:Brain edema associated with brain tumour is one of the most important factor contributing to the morbidity and mortality associated with brain tumour. The major mechanism for edema formation within and around brain tumour is abnormal permeability of newly created microvessels in the growing tumour. It was found that endothelial proliferation is common in malignant gliomas and that new tumour vessels are derived from previously existing vessels. However, these newly formed vessels are often defective. These defective vessels form an ineffective barrier and allow leakage of plasma exudates into the surrounding brain 1 . It is thought that enhancement of brain tumour by contrast media in CT and MRI is due to open interendothelial junctions, fenestrae, gap junctions and increased pinocytic vesicles in the capillaries of these tumours 2 . However, it is not known whether the putative defect, which governs the development of edema, is the same as one, which causes contrast enhancement. It is also not known whether these two factors are related to each other or how they are related to the degree of damage to the BBB. The present study is aimed finding association between the volume of peritumoural edema and the degree of contrast enhancement in MRI of diffusely infiltrating astrocytomas. Material and methods:

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Correlation between the degree of contrast enhancement and the volume of peritumoral edema in meningiomas and malignant gliomas

Cited by 44 publications

References 28 publications

Brain Edema in Neurooncology: Radiological Assessment and Management

Brain Edema in Neurooncology: Radiological Assessment and Management

Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus

MRI of Diffusely Infiltrating Intracranial Astrocytomas: Association between the Volume of Peritumoural Edema and the degree of Contrast Enhancement

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