Correlation between the ganglion cell complex and structural measures of the optic disc and retinal nerve fiber layer in glaucoma

Bresciani-Battilana, Erica; Teixeira, ivan Corso; Barbosa, Diego T. Q.; Caixeta-Umbelino, Cristiano; Paolera, Maurício Della; Kasahara, Niro

doi:10.1007/s10792-014-9988-7

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…GCC analysis has a significant correlation with RNFL study in both glaucoma patients and healthy individuals and probably has a higher diagnostic ability than RNFL, to detect the early glaucomatous damage [13]. Instead The correlations of GCC indices with the optic disk parameters are not equally strong (r>0,2), especially for GLV and FLV [14]. In patients with primary open angle glaucoma and glaucoma suspects patients the progression of the GCC damage follows the perimetric defects (P = 0.007) and presents a strong correlation (r > 0.60) with the visual fields indices [15,16].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

Georgalas

Taliantzis

Kazaki

et al. 2019

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Purpose: To evaluate the agreement of glaucomatous structural defects of the ganglion cell complex (GCC) detected with the spectral domain optical coherence tomography (sdOCT) with the optic nerve head alterations detected with the Heidelberg retina tomography (HRT), of glaucoma patients with ocular hypertension or open angle glaucoma. Material and Methods: Ninety patients eyes with structural glaucomatous defects were enrolled. All of them underwent imaging examination of GCC with sdOCT and the optic disk with HRT. The Cohen's kappa coefficient of agreement was used. Results: The agreement between the optic disc and GCC using the parameters of the programs analysis of the HRT, the moorfields regression analysis (MRA) and glaucoma probability score (GPS) was not significant. Instead between MRA and GPS a good agreement was calculated. Significant agreements were found between MRA and GPS on one hand and GCC on the other, considering location and length of the glaucomatous damage, while non significant agreements were found between GPS and GCC for the location and the length of the glaucomatous structural defect. Conclusions: There is no significance (Please explain further if you are referring to significance in terms of the difference, similarity or agreement) between HRT and sdOCT for the detection of the glaucomatous damage between the optic nerve head and the ganglion cell complex. Instead MRA and GCC detect comparable areas and lengths of the glaucomatous damage. On the other hand GPS records larger deficits relative to MRA and has not a significant agreement with the study of GCC.

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Section: Discussionmentioning

confidence: 99%

Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

Georgalas

Taliantzis

Kazaki

et al. 2019

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“…Similarly, Nogueira et al [16] study results displayed that there was a significant association between GCC thickness and optic disc (p=0.016). Also, Bresciani-Battilana et al [24] reported that rim area showed the best correlation with average GCC (r=0.583).…”

Section: Fig 5 Correlation Between Average Rnfl Thickness and Papille...mentioning

confidence: 94%

Correlation between Optical Coherence Tomography Ganglion Cell Layer Analysis and Visual Field in Cases of Benign Intracranial Hypertension

Saad,

Mohammed,

Soht

et al. 2024

JAMMR

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Background: Benign intracranial hypertension (BIH) is a condition in which there is excessive cerebral spinal fluid (CSF) pressure in the subarachnoid space that surrounds the brain and spinal cord (intracranial pressure (ICP)) owing to an unexplained cause. It affects 1:100,000 persons yearly with a 20 times greater prevalence in young, obese girls. We wanted to correlate between optical coherence tomography ganglion cell layer analyses and visual field in patients of benign intracranial hypertension. Methods: This cross-sectional clinical study that was carried out on 30 patients (60 eyes) who all had a recently diagnosed papilledema due to first episode of IIH. Goal of the study, and applied tests was done before obtaining an informed consent. Personal history, past medical and ocular history, possible risk factors for IIH were taken. Full ophthalmological examination including best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, pupillary reflexes, slit lamp bio microscopy examination including assessment of papilledema grade, blood pressure check and body mass index (BMI). All patients underwent automated perimetry in dim light to evaluate their visual field using SITA fast Standard 30-2 protocol by Humphrey Field Analyzer (Humphrey Field Analyzer I Carl Zeiss AG – Oberkochen – Germany). Results: Average RNFL thickness had significant positive correlation with rim area (r=0.654, P<0.001) and disc area (r=0.665, P<0.001). Average RNFL thickness had no correlation with VA, IOP and average CD. Average GCL complex had significant negative correlation with rim area (r= -0.283, P=0.028) and disc area (r= -0.328, P=0.01). Average GCL complex had no correlation with VA, IOP and average CD. Minimum GCL complex had significant negative correlation with rim area (r= -0.272, P=0.036) and disc area (r= -0.315, P=0.014). Minimum GCL complex had no correlation with VA, IOP and average CD. Papilledema grading had significant positive correlation with average RNFL thickness (r=0.461, P<0.001). Papilledema grading had no correlation with average GCL complex, minimum GCL complex, VFI, MD and PSD. Conclusions: There is a strong structure-function link between visual field indices and OCT parameters such as RNFL and GCC.

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Correlation between the ganglion cell complex and functional measures in glaucoma patients and suspects

et al. 2014

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The purpose of the study was to correlate the Fourier-domain OCT ganglion cell complex (GCC) parameters with automated perimetry (AP) functional measures of the optic nerve. This retrospective study included patients who had previously undergone examination with the RTVue-100 OCT and AP, SITA strategy. The parameters of GCC (average, superior, inferior, S-I [superior inferior difference], S-I SD [standard deviation of S-I], GLV [global loss volume] and FLV [focal loss volume]) were correlated with the mean deviation (MD) and pattern standard deviation (PSD) values of AP using linear and logarithmic regression analysis. All correlations between GCC and automated perimetry parameters were strong (r > 0.60), except that for SI and MD (r = -0.05); SI and PSD (r = 0.09); SI-DS and MD (r = -0.06); and SI-SD and PSD (r = 0.08). In summary, GCC derived structural measures showed good correlation with functional parameters from AP.

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Correlation between the ganglion cell complex and structural measures of the optic disc and retinal nerve fiber layer in glaucoma

Cited by 3 publications

References 19 publications

Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

Correlation between Optical Coherence Tomography Ganglion Cell Layer Analysis and Visual Field in Cases of Benign Intracranial Hypertension

Correlation between the ganglion cell complex and functional measures in glaucoma patients and suspects

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