Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis

Abstract

ABSTRACT. While increasing scientific evidence suggests that the ORMDL3 rs7216389 polymorphism may contribute to a higher susceptibility to asthma, many of the current studies have yielded inconclusive results. This meta-analysis aimed to assess the association between the ORMDL3 rs7216389 polymorphism and the risk of asthma. An extensive literature search for relevant studies was conducted in PubMed, Embase, the Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure, and Google Scholar. This metaanalysis was performed using the STATA 12.0 software. Crude odds ratios (OR) and their 95% confidence intervals (CI) were calculated. Thirteen studies were included with a total of 14,851 subjects, comprised of 6739 patients with asthma and 8112 healthy controls. Our meta-analysis results revealed that the ORMDL3 rs7216389 polymorphism may be associated with an increased risk of asthma (allele model: OR = 1.39, 95%CI = 1.27-1.52, P < 0.001; dominant model: OR = 1.46, 95%CI = 1.31-1.62, P < 0.001; recessive model: OR = 1.57, 95%CI = 1.37-1.81, P < 0.001; homozygous model: OR = 1.58, 95%CI = 1.32-1.90, P < 0.001; heterozygous model: OR = 1.54, 95%CI = 1.30-1.82, P < 0.001). We also found significant associations in our subgroup analyses based on ethnicity and type of asthma. However, in our subgroup analysis based on sources of controls, an association was found in the populationbased case-control subgroup but not in the hospital-based case-control subgroup. This meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma.

ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α–Endoplasmic Reticulum Stress–Beclin1 Autophagy Regulatory Pathway

“…In 2007, orosomucoid-like 3 (ORMDL3) was first reported to be associated with bronchial asthma and was subsequently replicated in various ethnic populations (13)(14)(15)(16)(17). Then several groups showed the association of ORMDL3 with type 1 diabetes (18), inflammatory bowel diseases (19), ankylosing spondylitis (20,21), and atherosclerosis (22).…”

Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

“…The past 20 years have seen a significant increase in the prevalence of asthma in children (Tang et al, 2015). The pathogenesis of asthma is related to multiple risk factors including environmental factors such as vehicular pollution, and genetic factors such as polymorphisms in the interleukin (IL)-4 and ORMDL3 genes (Favarato et al, 2014;Tang et al, 2014;Zhai et al, 2015).…”

Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population

“…[23][24][25] Association between ORMDL3 SNPs and asthma has been reported in Australian population (rs6503525), 26 Mexico City population (rs4378650), 27 Slovenian population (rs4795405), 28 and Chinese population (rs7216389). 29,30 The association of rs12603332 (-2352C/T) another ORMDL3 SNP with asthma was investigated in Chinese population and it has been found that individuals with T allele in rs12603332 are protected from asthma. 31 rs12603332 SNP which is located in the first intron lies in a conserved element across species with a high correlation to the consensus target sequence for the transcription factor E47.…”