Correlation between the immune responses to collagens type I, III, IV and V and Klebsiella pneumoniae in patients with Crohn's disease and ankylosing spondylitis

Tiwana, H.; Natt, R. S.; Benitez‐Brito, R.; Shah, Shilpan; Wilson, Clyde; Bridger, Stephen; Harbord, Marcus; Sarner, M.; Ebringer, Alan

doi:10.1093/rheumatology/40.1.15

Cited by 43 publications

(23 citation statements)

References 23 publications

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“…A positive correlation was also observed between Klebsiella and collagen antibody levels in these patients [54].…”

Section: Gut As the Main Source Of Klebsiella Infection In "As"supporting

confidence: 55%

Ankylosing Spondylitis, HLA-B27 and Klebsiella - An Overview: Proposal for Early Diagnosis and Treatment

Ebringer¹,

Rashid²,

Wilson³

et al. 2006

CRR

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Ankylosing spondylitis (AS) is a potentially disabling rheumatic disease for which no curative treatment has yet been discovered.An extensive computer-based and manual search was undertaken to evaluate the role of microbes in the pathogenesis of AS. All together 147 papers were scrutinised. A total of 24 studies carried out on 1330 AS patients and 1191 healthy controls involving 15 different countries showed significantly elevated Klebsiella antibodies in AS patients when compared to controls. Molecular analysis has shown that Klebsiella microbes possess antigens, which cross-react with self-antigens, such as HLA-B27 and spinal collagens.Diagnostic criteria have been developed in which a person who is HLA-B27 positive and has clinical and laboratory evidence of an inflammatory backache for at least three months is proposed to have pre-AS. A specific elevation of antiKlebsiella antibodies would confirm the diagnosis. A proposal for an early treatment using anti-Klebsiella measures is suggested.So far, apart from Klebsiella no other microbes have been shown to have a link with the development of AS. It is suggested that identifying and treating patients with Klebsiella reactive arthritis/pre-AS could involve the use of antiKlebsiella measures, such as antibiotics and low starch diet together with immunosuppressive drugs in an endeavour to prevent the irreversible sequelae of established AS.

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“…A positive correlation was also observed between Klebsiella and collagen antibody levels in these patients [54].…”

Section: Gut As the Main Source Of Klebsiella Infection In "As"supporting

confidence: 55%

Ankylosing Spondylitis, HLA-B27 and Klebsiella - An Overview: Proposal for Early Diagnosis and Treatment

Ebringer¹,

Rashid²,

Wilson³

et al. 2006

CRR

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“…K. pneumoniae also accounts for a substantial amount of hospital-acquired urinary tract infections, pneumonia, septicemias, meningitis, and soft tissue infections (5,33,39). The autoimmune disease ankylosing spondylitis is thought to be a possible sequela of K. pneumoniae infection (31). Although the molecular mechanisms of K. pneumoniae virulence are still not well understood, it has been proposed that the antiphagocytic capsule of K. pneumoniae plays a role in lung infections by preventing phagocytosis and suppressing the host immunological responses (14,17).…”

mentioning

confidence: 99%

Complete Nucleotide Sequence of Klebsiella pneumoniae Multiresistance Plasmid pJHCMW1

Sarno

McGillivary

Sherratt

et al. 2002

Antimicrob Agents Chemother

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The multiresistance plasmid pJHCMW1, harbored by a clinical Klebsiella pneumoniae strain isolated from a neonate with meningitis, was sequenced. A circular sequence of 11,354 bp was generated, of which 7,993 bp make up Tn1331, a transposon including the antibiotic resistance genes aac(6)-Ib, aadA1, bla OXA-9 , and bla TEM-1 . The gene aac(6)-Ib is included in a gene cassette, and both aadA1 and bla OXA-9 are included in a single-gene cassette that may have arisen as a consequence of a recombination event involving two integrons. The pJHCMW1 plasmid replicates through a ColE1-like RNA-regulated mechanism, includes a functional oriT, and two loci with similarity to XerCD site-specific recombination target sites involved in plasmid stabilization by the resolution of multimers. One of these two loci, mwr, is active and has been the subject of previous studies, and the other, dxs, is not functional but binds the recombinase XerD with low affinity. Two additional open reading frames were identified, one with low similarity to two hypothetical membrane proteins from Mycobacterium tuberculosis and Mycobacterium leprae and the other with low similarity to psiB, a gene encoding a function that facilitates the establishment of the transferring plasmid in the recipient bacterial cell during the process of conjugation.

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“…It is believed that having previous exposure to Klebsiella pneumoniae and expressing HLA-B27.5, a subtype of HLA-B27, confers susceptibility to AS. Higher levels of anti-K. pneumoniae antibodies have been reported in patients with AS compared with controls (Ebringer and Wilson, 2000;Trull et al, 1984;Tiwana et al, 2001). In addition, a six amino acid homology sequence has been found between the primary hypervariable region of HLA-B27.5 and that of the K. pneumoniae nitrogenase reductase (Frauendorf et al, 2003;Schwimmbeck et al, 1987) (see Table 2).…”

Section: The Molecular Mimicry Hypothesismentioning

confidence: 97%

Immunogenetics and rheumatoid arthritis: A review for orthopaedic nurses

Rankin

2005

Journal of Orthopaedic Nursing

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Correlation between the immune responses to collagens type I, III, IV and V and Klebsiella pneumoniae in patients with Crohn's disease and ankylosing spondylitis

Abstract: The role of K. pneumoniae and anti-collagen antibodies in the aetiopathogenesis of CD and AS requires further study.

Cited by 43 publications

References 23 publications

Ankylosing Spondylitis, HLA-B27 and Klebsiella - An Overview: Proposal for Early Diagnosis and Treatment

Ankylosing Spondylitis, HLA-B27 and Klebsiella - An Overview: Proposal for Early Diagnosis and Treatment

Complete Nucleotide Sequence of Klebsiella pneumoniae Multiresistance Plasmid pJHCMW1

Immunogenetics and rheumatoid arthritis: A review for orthopaedic nurses

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