Correlation Between the Radiologic and Histologic Size of Hepatocellular Carcinoma in Patients Eligible for Liver Transplantation

Mejía, Gilberto; Gómez, Manuel; Serrano, Juan Monte; García, Ignacio; Tamayo, María; Pareja, Felipe; Sousa, J.M.; Pascacio, J.M.; Gavilán, Francisco Socas; Castell, J.; Vargas, Brainy Omar Rodríguez; Bernardos, Á.

doi:10.1016/j.transproceed.2006.02.064

Cited by 11 publications

(13 citation statements)

References 8 publications

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“…In this study, we found 8 cm as a good cut-off point in stratifying patients with different prognosis. Furthermore, there are still some limitations in the sensitivity and accuracy of preoperative radiological imaging examinations (22). For example, a tumor with underestimated size or an additional satellite lesion found during operation may change the whole preoperative evaluation or even the transplantability, thus change the fate of a patient.…”

Section: Discussionmentioning

confidence: 99%

“…In 2003, De Carlis et al (25) reported both the 5-year survival rate and the tumor-free survival rate in patients with an AFP level lower than 20 ng/mL were significantly higher than those in patients with an AFP level exceeding 20 ng/mL (77.5% vs. 45.8%, Pϭ0.002; 100% vs. 71.3%, Pϭ0.002). Recently, Del Gaudio et al (22) reported that the 5-year survival was 66.2%, and the AFP level was identified as the only risk parameter for survival. One of our previous study had demonstrated that prognosis were worse in patients with pre-LT AFP level more than 400 ng/mL (26).…”

Section: Discussionmentioning

confidence: 99%

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Liver Transplantation for Hepatocellular Carcinoma: Hangzhou Experiences

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Liver Transplantation for Hepatocellular Carcinoma: Hangzhou Experiences

et al. 2008

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“…Nowadays, in literature, there are no reports providing physicians the accuracy of computed tomography and/or magnetic resonance in estimating the size of the liver metastases. Reports exist about the accuracy of computed tomography in estimating the size of renal tumors [18,19] and hepatocellular carcinoma [20][21][22][23]; for the latter, the results are controversial and for that not conclusive.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, there was no difference in terms of mean difference between pathological and radiological size between the patients with imaging performed close to resection and those who had imaging close to 21 days (p = 0.7). Moreover, this time limit is more restrictive than the one adopted in similar studies focused on hepatocellular carcinoma (60 and 90 days, respectively) [20,22].…”

Section: Discussionmentioning

confidence: 99%

Radiological estimation of size in colorectal liver metastases: is it reliable? Comparison with post-resectional measurements

et al. 2010

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Since the efficiency of percutaneous ablation techniques in treating colorectal liver metastases is dependent on tumor size, the aim of this study was to verify the accuracy of computed tomography or magnetic resonance in estimating the maximum diameter of colorectal liver metastases by comparing these findings with those of pathology in a series of patients who underwent liver resection. Radiological and pathological tumor measurements in 39 patients operated for 69 colorectal liver metastasis were recorded. The radiological measurement was performed by magnetic resonance in 40 tumors (23 cases) and by computed tomography in 29 tumors (16 patients). The mean difference between pathological and radiological sizes was 0.4 cm (p < 0.001). Radiological size was smaller than pathological size in 60.9% of tumors, equal in 16% and bigger in 23% of tumors. The results indicated that radiology significantly underestimates the diameter of liver metastasis. To avoid on-site recurrence after percutaneous ablation therapies due to inaccurate radiological measurement, a radiological size of colorectal metastasis up to 2.5 cm should be considered as selection criteria for this treatment.

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“…An advantage of these criteria is that their application by preoperative assessment was markedly associated with the survival and recurrence rates as to the histopathological evaluation of the explanted specimen. This shows that patient selection could be also partially based on pre-transplant radiographic findings, despite the potential deviations that may arise 33 .…”

Section: Asan Criteriamentioning

confidence: 99%

The Evolution of Criteria for Liver Transplantation for Hepatocellular Carcinoma: From Milan to San Francisco and All Around the World!

Ziogas¹,

Tsoulfas²

2017

RFMH

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Introduction: Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the third most common cancerrelated cause of death in the world. According to the stage of the disease, each patient is allocated to a different treatment option. Liver transplantation, along with surgical resection, is the only totally therapeutic option and is primarily indicated in HCC patients with underlying cirrhosis. However, the restricted number of liver grafts imposes difficulties in selecting the most suitable patients to receive those limited grafts and therefore certain criteria have been proposed. The Milan criteria are currently the most widely accepted and utilized criteria around the world, despite their restrictiveness. In an attempt to assist HCC patients exceeding them, but with a potential to display acceptable survival outcomes, undergo liver transplantation, research teams worldwide suggest expanded criteria based on their findings. Some of the most broadly known are the University of California, San Francisco (UCSF), Kyoto, Tokyo, Hangzhou and up-to-7 criteria. On the other hand, in order to expand the liver donor pool, grafts may be accepted from living, non-heart beating, elderly, steatotic, or even HCV-infected donors, in addition to the use of split livers with both advantages and disadvantages. The aim of this review is to thoroughly present the current situation of liver transplantation for HCC patients, with a focus on the criteria used and emerging challenges presented. Core tip: Hepatocellular carcinoma (HCC) is the third most common malignancy worldwide and liver transplantation represents the treatment of choice, particularly in the setting of cirrhosis. Lack of grafts led to the utilization of certain criteria in order to determine the eligibility of an HCC patient to access the waiting list. The most widely accepted are the Milan criteria, even though they are thought off as too restrictive. Consequently, transplant research groups all over the world published their own criteria, which showed acceptable outcomes. Living donor liver transplantation and other extended-criteria grafts have been proposed as an alternative to reduced donations. Ziogas IA, Tsoulfas G. The evolution of criteria for liver transplantation for hepatocellular carcinoma: from Milan to San Francisco and all around the world!

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Correlation Between the Radiologic and Histologic Size of Hepatocellular Carcinoma in Patients Eligible for Liver Transplantation

Cited by 11 publications

References 8 publications

Liver Transplantation for Hepatocellular Carcinoma: Hangzhou Experiences

Liver Transplantation for Hepatocellular Carcinoma: Hangzhou Experiences

Radiological estimation of size in colorectal liver metastases: is it reliable? Comparison with post-resectional measurements

The Evolution of Criteria for Liver Transplantation for Hepatocellular Carcinoma: From Milan to San Francisco and All Around the World!

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