Correlation between the Severity of Metabolic Dysfunction-Associated Fatty Liver Disease and Serum Uric Acid to Serum Creatinine Ratio

Abstract

Purpose. As one of the most common chronic liver diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) had different prognoses between mild and moderate-severe levels. Serum uric acid to serum creatinine ratio (sUA/Cr) can reflect the overall metabolic status of the body. To explore a convenient indicator to screen MAFLD and distinguish the severity of the disease, this study analyzed the correlation between sUA/Cr and the severity of MAFLD. Methods. 228 participants were enrolled and divided into 2 groups, including mild MAFLD and non-MAFLD group and moderate-severe MAFLD group, based on liver/spleen computed tomography (CT) ratios. The correlations between sUA/Cr and the severity of MAFLD were analyzed by logistic and linear regression. Receiver operating characteristics (ROCs) analyzed the predictive ability of sUA/Cr for the severity of MAFLD expressed by the area under curve (AUC). Results. The level of sUA/Cr was higher in themoderate-severe MAFLD group than mild MAFLD and non-MAFLD group (6.14 ± 1.55 vs. 5.51 ± 1.19, P = 0.008 ). After adjustment for confounders, the correlation analysis showed that patients with elevated sUA/Cr had a higher risk of moderate-severe MAFLD (OR: 1.350, P = 0.036 ). A higher sUA/Cr level was associated with lower liver CT values (β = −0.133, P = 0.039 ) and liver/spleen CT ratio (β = −0.154, P = 0.016 ). sUA/Cr had the ability to discriminate the severity of MAFLD (AUC: 0.623). Conclusion. sUA/Cr was positively associated with the risk of moderate-severe MAFLD and had the predictive ability to discriminate the moderate-severe MAFLD from mild MAFLD and non-MAFLD. The sUA/Cr level was suggested to be monitored and controlled in the screening and treatment of MAFLD.

Lower serum uric acid to serum creatinine ratio as a predictor of poor functional outcome after mechanical thrombectomy in acute ischaemic stroke

“…As the product of purine metabolism, uric acid is primarily metabolized by the kidneys, and its effect on ischaemic stroke may be modulated by renal function. Therefore, the recently proposed standardized uric acid level (SUA/SCr) as a new biomarker could more accurately reflect the net production of uric acid, aiding in the understanding of the complex interplay between metabolism and cardio-cerebrovascular diseases [37,38].…”

Analysis of risk factors for fatty liver disease in children with Wilson’s disease

“…Additionally, we showed creatinine levels as an independent risk factor for FLD in children with Wilson’s disease. Previous studies have shown that the ratio of serum uric acid levels to creatinine levels is significantly associated with NAFLD and is positively correlated to the risk of moderate-to-severe FLD [ 36 ], which is an independent predictor of NAFLD [ 37 , 38 ]. A few studies have investigated the correlation between fibrinogen and laminin levels, a biochemical index to evaluate liver fibrosis, and fatty liver.…”

The Association of Serum Uric Acid Levels and Various Uric Acid-Related Ratios with Insulin Resistance and Obesity: A Preliminary Study in Adolescents

“…Creatinine, a chemical waste product of creatine, is affected by the number of muscles, food intake, and kidney function. The UCR represents the metabolic status, excluding the influence of kidney function [ 35 ]. The UCR has emerged as a new biomarker and is considered an excellent indicator of uric acid production [ 16 ].…”