Correlation Between the Structure and Function of the Rabbit Urinary Bladder Following Partial Outlet Obstruction

Abstract

Prolonged partial bladder outflow obstruction is accompanied by a progressive decrease in contractility of SM. The present study describes the structural damage that occurs in the bladder wall in response to partial outlet obstruction and correlates these observations with the contractile dysfunction with which it is associated. Furthermore, mitochondrial damage in vessels and fibroblasts is suggestive of bladder wall ischemia.

Tadalafil, a phosphodiesterase type 5 inhibitor, improves bladder blood supply and restores the initial phase of lower urinary tract dysfunction in diabetic rats

“…4 Chronic partial bladder outlet obstruction causes bladder ischemia leading to a progressive decrease in detrusor contractility. 5,6 According to previous reports, clinical causes, including insufficient blood supply (ie, arteriosclerosis) and bladder outlet obstruction (ie, BPH), induce ischemia and the ischemia/reperfusion cycle is accompanied by micturition and neurogenic and/or myogenic contractile dysfunction. 7 Diabetes impairs vascular endothelial function due to nitric oxide (NO) hyposecretion and causes atherosclerosis, resulting in reduced blood supply.…”

Effect of hydrogen peroxide on rabbit urinary bladder citrate synthase activity in the presence and absence of a grape suspension

“…Recent evidence has demonstrated that ischemia followed by reperfusion are major etiological factors in obstructive bladder dysfunction (3,4). Specifically, blood flow to the bladder's smooth muscle and mucosa decrease with obstructive Basic and Translational Urology doi: 10.1590/S1677-55382010000600014 dysfunction resulting in tissue hypoxia, increased free radical generation, decreased contraction, denervation, and mitochondrial dysfunction (5)(6)(7).…”

“…From our studies on partial outlet obstruction and bilateral ischemia, we have shown that mitochondria are one of the most sensitive sub-cellular organelles to develop oxidative stress and free radical damage (3,4,(24)(25)(26)(27). We use citrate synthase as a marker enzyme for mitochondrial function (28,29).…”

Assessment of microheterogeneity of blood flow in the rat urinary bladder by high‐resolution digital radiography

“…There are several studies of the relationship between bladder dysfunction and blood flow [1,2], with a heterogeneous distribution of blood flow in the bladder, and large differences in blood flow between the muscular and mucosal layers reported [3][4][5][6]. The relationship between bladder dysfunction and blood flow has also been recognised.…”