Correlation between umbilical resistance index and fetal growth: Pilot study

Kéhila, M; Touhami, Omar; Hmid, Rim Ben; Abouda, Hassine Saber; Abdeljelil, Khlifi; Ayachi, A.; Mourali, Mechaal; Khaïri, H.; Chanoufi, Mohamed Badis

doi:10.1111/jog.13274

Cited by 4 publications

(7 citation statements)

References 14 publications

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“…Further, Ebbing et al 11 reported a progressive increase of UVBF during the third trimester in pregnancies complicated by fetal macrosomia. Conversely, the previously reported occurrence of a low pulsatility index in the uterine or umbilical arteries in macrosomic fetuses was not confirmed in our population despite an observed lower but non‐significant trend in such fetuses 12,14‐17,32 . Similarly, our data do not confirm the reported association between cerebroplacental ratio and fetal weight 33 …”

Section: Discussioncontrasting

confidence: 99%

“…Conversely, the previously reported occurrence of a low pulsatility index in the uterine or umbilical arteries in macrosomic fetuses was not confirmed in our population despite an observed lower but non-significant trend in such fetuses. 12,[14][15][16][17]32 Similarly, our data do not confirm the reported association between cerebroplacental ratio and fetal weight. 33 Prospective design, inclusion of consecutive pregnancies, large sample size, assessment of umbilical vein hemodynamic for all the included cases and statistical analysis adjusted for all the main possible confounders represent the main strengths of this study.…”

Section: Discussioncontrasting

confidence: 99%

“…is increased 11 while impedance to blood flow in the uterine 12 and umbilical arteries is reduced in pregnancies complicated by fetal macrosomia. [11][12][13][14][15][16][17] The primary aim of this study was to elucidate the diagnostic performance of fetal venous and arterial Dopplers in predicting macrosomia in the third trimester of pregnancy; the secondary aim was to build a multiparametric prediction model including pregnancy, ultrasound and Doppler characteristics able to improve the prediction of macrosomia.…”

Section: It Has Been Recently Reported That Umbilical Vein Blood Flow (Uvbf)mentioning

confidence: 99%

“…Fetal growth is closely linked to placental circulation; thus, it is surprising that the large majority of previously published studies do not take into account the role of Doppler in predicting macrosomia. It has been recently reported that umbilical vein blood flow (UVBF) is increased 11 while impedance to blood flow in the uterine 12 and umbilical arteries is reduced in pregnancies complicated by fetal macrosomia 11‐17 …”

Section: Introductionmentioning

confidence: 99%

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The added value of umbilical vein flow in predicting fetal macrosomia at 36 weeks of gestation: A prospective cohort study

Rizzo

Mappa

Bitsadze

et al. 2021

Acta Obstet Gynecol Scand

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Introduction Current models based on fetal biometry and maternal characteristics have a poor performance in predicting macrosomia. The primary aim of this study was to elucidate the diagnostic performance of fetal venous and arterial Dopplers in predicting macrosomia in the third trimester of pregnancy; the secondary aim was to build a multiparametric prediction model including pregnancy, ultrasound and Doppler characteristics able to predict macrosomia accurately. Material and methods Prospective cohort study including 2156 singleton pregnancies scheduled for routine ultrasound assessment at 36 weeks of gestation. Fetal biometry, estimated fetal weight (EFW), pulsatility index of the uterine, umbilical, and middle cerebral arteries, cerebroplacental ratio and umbilical vein blood flow (UVBF) normalized for fetal abdominal circumference (UVBF/AC) were recorded. Primary outcome was the prediction of fetal macrosomia, defined as a birthweight >90th percentile; secondary outcome was the prediction of newborns >4000 g. Logistic regression and area under the curve (AUC) analyses were used to analyze the data. Results Fetal macrosomia complicated 9.8% of pregnancies, and 7.7% of newborns had a birthweight >4000 g. At multivariate logistic regression analysis, maternal body mass index (adjusted odds ratio [aOR] 1.23), pregestational diabetes (aOR 1.83), a prior newborn with a birthweight >95th centile (aOR 1.49), EFW (aOR 2.23) and UVBF (aOR1.84) were independently associated with macrosomia, whereas gestational diabetes mellitus (P = .07) or any of the other Doppler parameters were not. EFW had an AUC of 0.750 and of 0.801 alone and in association with maternal characteristics for the prediction of macrosomia, respectively. The addition of UVBF to this model significantly improved the prediction of fetal macrosomia provided by maternal and ultrasound parameters with an AUC of 0.892 (De Long P = .044 and P = .0078, respectively). The predictive performance for birthweight >4000 g was similar and significantly improved when UVBF was included in the diagnostic algorithm. Conclusions Umbilical vein blood flow evaluation in the third trimester improves the diagnosis of fetal macrosomia. The optimal diagnostic performance for macrosomia is achieved by a multiparametric model including umbilical vein flow, maternal characteristics and EFW.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: It Has Been Recently Reported That Umbilical Vein Blood Flow (Uvbf)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The added value of umbilical vein flow in predicting fetal macrosomia at 36 weeks of gestation: A prospective cohort study

Rizzo

Mappa

Bitsadze

et al. 2021

Acta Obstet Gynecol Scand

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“…The highest prevalence was reported by Yoon et al, who reported a prevalence of AEDF or REDF of 2.13% amongst 328 unselected-risk women in South Korea [38]. The four studies (898 women) conducted in lower middle-income countries (Bangladesh, Papua New Guinea, Nigeria and Tunisia) did not report any cases of AEDF or REDF [39][40][41][42]. Similarly, a three-country prospective cohort study of 431 healthy, low-risk women by Drukker et al in Brazil, Kenya and the UK identified no AEDF cases in any country [29].…”

Section: Resultsmentioning

confidence: 91%

Prevalence of abnormal umbilical arterial flow on Doppler ultrasound in low-risk and unselected pregnant women: a systematic review

et al. 2021

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Background While Doppler ultrasound screening is beneficial for women with high-risk pregnancies, there is insufficient evidence on its benefits and harms in low- and unselected-risk pregnancies. This may be related to fewer events of abnormal Doppler flow, however the prevalence of absent or reversed end diastolic flow (AEDF or REDF) in such women is unknown. In this systematic review, we aimed to synthesise available data on the prevalence of AEDF or REDF. Methods We searched PubMed, Embase, CINAHL, CENTRAL and Global Index Medicus with no date, setting or language restrictions. All randomized or non-randomized studies reporting AEDF or REDF prevalence based on Doppler assessment of umbilical arterial flow > 20 weeks’ gestation were eligible. Two authors assessed eligibility and extracted data on primary (AEDF and REDF) and secondary (fetal, perinatal, and neonatal mortality, caesarean section) outcomes, with results presented descriptively. Results A total of 42 studies (18,282 women) were included. Thirty-six studies reported zero AEDF or REDF cases. However, 55 AEDF or REDF cases were identified from just six studies (prevalence 0.08% to 2.13%). Four of these studies were in unselected-risk women and five were conducted in high-income countries. There was limited evidence from low- and middle-income countries. Conclusions Evidence from largely observational studies in higher-income countries suggests that AEDF and REDF are rare among low- and unselected-risk pregnant women. There are insufficient data from lower-income countries and further research is required.

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Hereditary thrombophilia and low -molecular -weight heparin in women: useful determinants, including thyroid dysfunction, incorporating the management of treatment and outcomes of the entity

Dugalić¹,

Petronijević

Şengül

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE: Our study purposed to examine the complex relationship between low-molecular-weight heparin therapy, multiple pregnancy determinants, and adverse pregnancy outcomes during the third trimester in women with inherited thrombophilia. METHODS: Patients were selected from a prospective cohort of 358 pregnant patients recruited between 2016 and 2018 at the Clinic for Obstetrics and Gynecology, University Clinical Centre of Serbia, Belgrade. RESULTS: Gestational age at delivery (β=-0.081, p=0.014), resistance index of the umbilical artery (β=0.601, p=0.039), and d-dimer (β=0.245, p<0.001) between 36th and 38th weeks of gestation presented the direct predictors for adverse pregnancy outcomes. The model fit was examined using the root mean square error of approximation 0.00 (95%CI 0.00-0.18), the goodness-of-fit index was 0.998, and the adjusted goodness-of-fit index was 0.966. CONCLUSION: There is a need for the introduction of more precise protocols for the assessment of hereditary thrombophilias and the need for the introduction of low-molecular-weight heparin.

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Correlation between umbilical resistance index and fetal growth: Pilot study

Abstract: In normal pregnancies there seems to be a linear relationship between umbilical RI measured at 31-34 weeks of gestation and average fetal growth in the third trimester. The greater the resistance index, the lower the weight gain.

Cited by 4 publications

References 14 publications

The added value of umbilical vein flow in predicting fetal macrosomia at 36 weeks of gestation: A prospective cohort study

The added value of umbilical vein flow in predicting fetal macrosomia at 36 weeks of gestation: A prospective cohort study

Prevalence of abnormal umbilical arterial flow on Doppler ultrasound in low-risk and unselected pregnant women: a systematic review

Hereditary thrombophilia and low -molecular -weight heparin in women: useful determinants, including thyroid dysfunction, incorporating the management of treatment and outcomes of the entity

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