Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine

Yamada, Shuta; Chiba, Ko; Okazaki, Narihiro; Era, Makoto; Nishino, Yuichiro; Yokota, Kazuaki; Yonekura, Akihiko; Tomita, Masato; Tsurumoto, Toshiyuki; Osaki, Makoto

doi:10.1016/j.bone.2018.12.005

Cited by 13 publications

(4 citation statements)

References 40 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The micro-CT system can calculate the density of the selected three-dimensional ROIs, and the BV/TV can be calculated based on the three-dimensional reconstruction of voxels. Yamada et al 23 have used high-resolution 3D micro-CT to study the microstructure of lumbar vertebrae. The BV/TV was closely related to the vertebral strength in their compression destruction experiment.…”

Section: Discussionmentioning

confidence: 99%

Exploring the micromorphological characteristics of adult lower cervical vertebrae based on micro-computed tomography

Li,

Yang,

Wang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

We will use micro-computed tomography to scan 31 sets of the adult lower cervical vertebrae (155 vertebrae) to observe the morphological characteristics and direction of trabeculae in the lower cervical vertebrae by outlining and reconstructing the regions of interest and to calculate the variation laws of the microstructure in the regions of interest to reveal their structural characteristics and weak areas. As a result, the images showed that the trabeculae in the lower cervical pedicle near the medial and lateral cortices were relatively dense, and their bone plates were lamellar. There were cavities between the superior and inferior articular processes where the ossification centers had not been absorbed after ossified. The lamellar trabeculae in the vertebral plates near the cortical bones were only 1–2 layers, extended and transformed into rod-shaped trabeculae in a radial shape toward the medullary space. The lamellar trabeculae of the vertebral plate extend over the spinous process near the cortical bone. The statistical results of the trabeculae's morphological parameters showed significant differences in bone volume fraction values among the four parts (P < 0.05). There were substantial differences in BS/BV, except for no differences between the pedicle and the vertebral plate (P < 0.05). There was a significant difference in trabecular pattern factor values between the articular process, the spinous process, and the vertebral plate (P < 0.05) and a significant difference between the pedicle, the spinous process, and the vertebral plate (P < 0.05). There were no significant differences in trabecular bone thickness and trabecular space values among the four parts (P < 0.05). The anatomical microstructural perspective confirms that the optimal choice is internal fixation via the pedicle. If using pedicle screws, the nail tract needs to be placed into the spinous process to increase its holding power and resistance to extraction.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the micromorphological characteristics of adult lower cervical vertebrae based on micro-computed tomography

Li,

Yang,

Wang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…[11][12][13][14] The micro-CT system can calculate the density of the selected 3D ROI, and the trabecular volume fraction can be calculated based on 3D reconstruction of voxels. Yamada et al [15] used high-resolution 3D micro-CT to study the microstructure of the lumbar spine and measure the volume fraction of the bone trabecula. It was found that high-resolution 3D assessment of the normal lumbar spine helped to better clarify the microstructure changes.…”

Section: Discussionmentioning

confidence: 99%

Examination of the microstructures of the lower cervical facet based on micro-computed tomography: A cadaver study

Jun

et al. 2022

Medicine

View full text Add to dashboard Cite

The cervical facet has complicated 3D microstructures and inhomogeneities. The cervical facet joint, which also participates in the formation, plays a certain role in regulating and limiting the movement of the spine. Correct identification and evaluation of its microstructure can help in the diagnosis of orthopedic disease and predict early phases of fracture risk. To evaluate the safety of the cervical spine by measuring and analyzing the microstructures and morphometric parameters of bone trabeculae in the normal cervical facet with high-resolution 3D micro-computed tomography. Thirty-one sets of C3 to C7 lower cervical vertebrae (155 vertebrae) were scanned using micro-computed tomography. The morphological characteristics and direction of trabecular bone in the facet of the lower cervical vertebrae were observed by selecting and rebuilding the areas of interest, and the changes in the microstructure of the areas of interest were calculated to reveal the structural characteristics and weak areas. Images indicated an ossified center between the superior and inferior articular processes of the lower cervical spine. The cellular bone trabeculae of the articular process had complex reticular microstructures. The trabecular bone plate near the cortical bone was lamellar and relatively dense, and it extended around and transformed into a network structure, and then into the rod-shaped trabecular bone. The rod-shaped trabeculae converged with the plate-shaped trabeculae with only 1 to 2 layers surrounding the trabeculae cavity. Statistical results of the morphological parameters of the trabecular bone showed that trabecular bone volume fraction values were significantly higher for C7 than for C3 to C6 (P < .05). There were significant differences between C7 and C3 to C5 and between C6 and C4 in bone surface area/bone volume (P < .05). There was a significant difference between C7 and C3 to C6 in trabecular bone thickness values (P < .05). The degree of anisotropy value was significantly smaller for C3 than for C6 and C7 (P < .05). The changes in the C3 to C7 microstructure were summarized in this study. The loading capacity and stress of the C7 articular process tended to be limited, and the risk of injury tended to be higher for the C7 articular process.

show abstract

“…Bone microstructure imaging can accurately re ect the changes of bone microstructure at an early stage, which is both helpful for the investigation of the microstructure mechanism of osteoporosis and the subsequent evaluation of the e cacy of interventional therapy. In recent years, many scholars have studied the relationship between bone microstructure parameters and bone strength to obtain bone microstructure indicators that are most relevant to fracture risk [15][16][17]. However, these results were often contradictory to each other, which might be related to the different samples, measurement sites and experimental methods adopted.…”

Section: Introductionmentioning

confidence: 99%

Study and Prediction of Bone Strength of Osteoporosis Model Based on Synchrotron Radiation

Li¹,

Xu²,

Zhang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: As the gold standard for clinical osteoporosis diagnosis, bone mineral density has significant limitations in bone strength assessment and fracture risk prediction. The purpose of this study is to explore a new osteoporotic bone quality evaluation criteria from both diagnosis site selection and bone strength prediction. Methods: Ovariectomized rats with different intensity swimming therapy were investigated in this study. The lumbar vertebrae and femurs of all the rats were scanned by synchrotron radiation computed tomography. Bone microstructure analysis and finite element analysis were combined to obtain bone microstructure parameters and estimated bone strength. And the sensitivity of different skeletal sites to therapy was explored. An elastic network regression model was established to predict bone strength by integrating additional bone microstructure characteristics besides bone mass.Results: Histomorphometry analysis showed that swimming therapy could reduce the risk of osteoporosis of lumbar vertebrae and femur and suggested that the femur might be a more suitable site for osteoporosis diagnosis and efficacy evaluation than the lumbar vertebrae. The average coefficient of determination and average root mean squared error of our predictive model were 0.774 and 0.110. Bland-Altman analysis showed that our model could be a good alternative to the finite element method. Conclusions: The present study developed a machine learning model for prediction of bone strength of osteoporosis model based on synchrotron x-ray imaging and demonstrated that different skeletal sites had different sensitivity to therapy, which is of great significance for the early diagnosis of osteoporosis, the prevention of fractures and the monitoring of therapy.

show abstract

Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine

Cited by 13 publications

References 40 publications

Exploring the micromorphological characteristics of adult lower cervical vertebrae based on micro-computed tomography

Exploring the micromorphological characteristics of adult lower cervical vertebrae based on micro-computed tomography

Examination of the microstructures of the lower cervical facet based on micro-computed tomography: A cadaver study

Study and Prediction of Bone Strength of Osteoporosis Model Based on Synchrotron Radiation

Contact Info

Product

Resources

About