Correlation between Visual Acuity and Micro Structural Changes after Intravitreal Bevacizumab Therapy in Naive Idiopathic Choroidal Neovascularization

Shah, Sajid Ali; Kang, Qian Yan; Fan, Xiao Juan; Shahbaz, Faisal

doi:10.15406/aovs.2015.02.00060

Cited by 1 publication

(1 citation statement)

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“…Idiopathic choroidal neovascularization (ICNV) occurs without clear causes in patients younger than 50 years. It is distinct from CNV secondary, pathological myopia, angioid streaks, multifocal choroiditis, punctate inner choroidopathy, presumed ocular histoplasmosis syndrome, and trauma [ 1 , 2 ]. Choroidal neovascularization (CNV) causes exudation, hemorrhage, and fibrosis at the macula resulting in poor central vision and visual loss.…”

Section: Introductionmentioning

confidence: 99%

The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization

Chen

Sun

et al. 2016

Journal of Ophthalmology

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Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical coherence tomography (SD-OCT) and OCTA in this observational study. The timing of observation was before treatment, 1 day after treatment with intravitreal anti-VEGF injection, and 1 month after the treatment. The central retina thickness (CRT) on SD-OCT, selected CNV area, and flow area on OCTA were measured. Results. A total of 17 eyes from 17 patients with ICNV were included in this study. OCTA showed visible irregular choroidal neovascularization with “tree-in-bud” form on outer retinal layer. After treatment, as well as in the 1-day follow-up, CNV decreased in size from the periphery, and the vessel density was reduced. As shown on OCTA, the selected CNV area and flow area were significantly reduced compared to pretreatment. The rate of CNV vessel area changes was higher on OCTA than the changes in CRT on SD-OCT at 1-day and 1-month follow-up. Conclusion. Intravitreal injection of anti-VEGF is effective for idiopathic choroidal neovascularization, and the treatment outcomes are observable after 1 day. OCTA provides a useful approach for monitoring and evaluating the treatment of intravitreal anti-VEGF for CNV.

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Section: Introductionmentioning

confidence: 99%