Correlation between Visual Function and Structural Characteristics of the Macula in Advanced Retinitis Pigmentosa

Son, Gisung; Lee, Suhwan; Kim, Yoon Jeon; Lee, Joo Yong; Kim, June-Gone; Yoon, Young Hee

doi:10.1159/000496941

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…Parameters such as central foveal thickness, submacular choroidal thickness (measured with standard and enhanced depth imaging) and macular volume are significantly reduced in patients with RCD, when compared with normal controls. 75 However, these latter parameters are not always correlated with visual function, thereby measuring the EZ remains one of the most sensitive ways of tracking the progression of RCD. 76 In addition, outer nuclear layer-foveal thickness has been frequently used as a surrogate measurement of foveal cone number, even though studies employing adaptive optics cellular imaging have proved the lack of correlation between these two parameters in conditions such as achromatopsia (ACHM).…”

Section: Introductionmentioning

confidence: 99%

Structural evaluation in inherited retinal diseases

et al. 2021

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Ophthalmic genetics is a field that has been rapidly evolving over the last decade, mainly due to the flourishing of translational medicine for inherited retinal diseases (IRD). In this review, we will address the different methods by which retinal structure can be objectively and accurately assessed in IRD. We review standard-of-care imaging for these patients: colour fundus photography, fundus autofluorescence imaging and optical coherence tomography (OCT), as well as higher-resolution and/or newer technologies including OCT angiography, adaptive optics imaging, fundus imaging using a range of wavelengths, magnetic resonance imaging, laser speckle flowgraphy and retinal oximetry, illustrating their utility using paradigm genotypes with on-going therapeutic efforts/trials.

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Section: Introductionmentioning

confidence: 99%

Structural evaluation in inherited retinal diseases

et al. 2021

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“…To overcome these potential problems, relationships between the structure and function have been extensively investigated in order to utilize the objective and quantitative parameters obtained from spectral-domain optical coherence tomography (SD-OCT) to assess the central retinal sensitivity of patients with RP . Previously, among several quantitative parameters, the width of the inner segment ellipsoid zone (IS-EZ) [1,3,7,8,10,13,14,18,19,21,24] and thickness of the outer retinal layer [2,4,9,12,15,20,23] have been shown to be significantly correlated with the central visual sensitivity. However, in these quantitative analyses, the subjects should be restricted to patients with visual acuity better than a certain level or measurable structural changes for analyzing the correlation between structural parameters and the visual function [1,9,10,12,13,15,18,20,21].…”

Section: Introductionmentioning

confidence: 99%

The qualitative assessment of optical coherence tomography and the central retinal sensitivity in patients with retinitis pigmentosa

et al. 2020

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To analyze the relationships between qualitative and quantitative parameters of spectraldomain optical coherence tomography (SD-OCT) and the central retinal sensitivity in patients with retinitis pigmentosa (RP). Materials and methods Ninety-three eyes of 93 patients were finally enrolled, with a median age (quartile) of 58 (24.5) years. We assessed the patients using SD-OCT and the 10-2 program of a Humphry Field Analyzer (HFA). As a qualitative parameter, two graders independently classified the patients' SD-OCT images into five severity grades (grades 1-5) based on the severity of damage to the photoreceptor inner and outer segments (IS/OS) layer. As quantitative parameters, we measured the IS-ellipsoid zone (IS-EZ) width, IS/OS thickness, outer nuclear layer (ONL) thickness, central macular thickness (CMT, 1 and 3 mm) and macular cube (6 × 6 mm) volume and thickness. The central retinal sensitivity was defined by the best-corrected visual acuity (BCVA; logMAR), average sensitivities of the central 4 (foveal sensitivity [FS]) and 12 (macular sensitivity [MS]) points of the HFA 10-2 program and the mean deviation (MD) of the 10-2 program. Spearman's correlation was used to assess the association between both qualitative and quantitative parameters and variables of the central retinal sensitivity. In addition, we performed a multiple regression analysis using these parameters to identify the parameters most strongly influencing the central retinal sensitivity. Results The IS/OS severity grade was significantly correlated with the BCVA (ρ = 0.741, P < 0.001), FS (ρ = −0.844, P < 0.001), MS (ρ = −0.820, P < 0.001) and MD (ρ = −0.681, P < 0.001) and showed stronger correlations to them than any other quantitative parameters including the IS-EZ width, IS/OS thickness, ONL thickness, CMTs and macular cube volume/thickness. Furthermore, a step-wise multiple regression analysis indicated that the IS/OS severity grade was more strongly associated with the BCVA (β = 0.659, P < 0.001), FS (β = −0.820,

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“…To evaluate the therapeutic efficacy of these treatment options, it is important to measure the severity of the disease. Also for the clinical assessment and VA, the disease can be examined by a variety of tests like optical cohorence tomography (OCT), VF and electroretinography (ERG) [5].…”

Section: Introductionmentioning

confidence: 99%

A New Classification for Retinitis Pigmentosa Including Multifocal Electroretinography to Evaluate the Disease Severity

Öner¹,

Kahraman²

2023

OJOph

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Aim: To establish a useful and objective classification for retinitis pigmentosa (RP) to evaluate the disease severity. Methods: This is a retrospective crosssectional study. Visual acuity (VA), visual field (VF) width, ellipsoid zone width on optic cohorence tomography (OCT) and multifocal electroretinography (mf ERG) values were obtained from medical records of patients with RP. A scoring criterion was developed wherein each variable was assigned a score from 0 to 5 depending on its distribution. The cumulative score (from 0 to 20) was used to classify disease severity from grade 0 to 5. The scores were correlated with each other and the final grade. Results: Data of 152 eyes of 92 patients who had the results of all tests were reviewed. The mean age was 41.2 years. The mean VA of the patients was 0.13 ± 0.16 Snellen lines. The majority of patients had a VA less than 20/40 (88.6%), a visual field smaller than 20˚ (78%), and an ellipsoid zone width smaller than 7˚ (84.4%). The majority of the patients (85.4%) were in advanced stage of the disease (Grade 4 and 5). Conclusions: We present a simple, objective and easy to use disease severity classification for RP which can be used to categorize patients and to evaluate and compare treatment results.

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Correlation between Visual Function and Structural Characteristics of the Macula in Advanced Retinitis Pigmentosa

Cited by 12 publications

References 26 publications

Structural evaluation in inherited retinal diseases

Structural evaluation in inherited retinal diseases

The qualitative assessment of optical coherence tomography and the central retinal sensitivity in patients with retinitis pigmentosa

A New Classification for Retinitis Pigmentosa Including Multifocal Electroretinography to Evaluate the Disease Severity

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