Correlation Between β<sub>2</sub>‐Glycoprotein Antibodies and Antiphospholipid Antibodies in Patients with Reproductive Failure

Chong, Penny; Matzner, William; Ching, Wendell

doi:10.1111/j.1600-0897.1998.tb00427.x

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…Unfortunately IgM isotype was not evaluated. In contrast, several studies showed no association between anti-2-GPI and pregnancy loss or reproductive failure [39,[76][77][78]. Moreover, testing for anti-2-GPI seems not to identify additional patients with spontaneous abortion or unexplained fetal death who initially have negative results on LA or aCL assays [73,77,78].…”

Section: As Markers Of Apsmentioning

confidence: 83%

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Carreras

Forastiero

Martinuzzo

2000

Journal of Autoimmunity

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Section: As Markers Of Apsmentioning

confidence: 83%

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Carreras

Forastiero

Martinuzzo

2000

Journal of Autoimmunity

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“…Other study including 195 women with two or more unexplained consecutive miscarriages demonstrated that LA and IgG anti-β 2 GPI were associated with pregnancy loss but only LA was related to second trimester fetal loss [91]. In contrast, a number of studies showed no association between anti-β 2 GPI and/or anti-PT and pregnancy loss or reproductive failure [73,77,[92][93][94][95][96][97]. Besides, testing for anti-β 2 GPI seems not to identify additional patients with spontaneous abortion or unexplained fetal death who initially have negative results on LA or aCL assays [73,94,95].…”

Section: Clinical Studiesmentioning

confidence: 95%

Antigen Specificity and Clinical Relevance of Antiphospholipid Syndrome- Related Autoantibodies

Forastiero¹,

Martinuzzo

2005

CRR

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The presence of antiphospholipid antibodies (aPL) combined with venous or arterial thrombosis, and/or obstetric complications defines the antiphospholipid syndrome (APS). Lupus anticoagulants (LA) and anticardiolipin antibodies (aCL) were the first described aPL. It has been shown that aPL, despite their name, are not directed against anionic phospholipids, as had previously thought, but are a part of a large family of autoantibodies against phospholipid-binding plasma proteins. The most important and relevant antigenic targets involved in APS are β 2 glycoprotein I (β 2 GPI) and prothrombin. However, an increasing number of other phospholipid-binding proteins with crucial functions in the regulation of blood coagulation and fibrinolysis are also targeted by APS-related autoantibodies. For clinical purposes, it is important to find which aPL markers has the best prognostic value. While it has been clearly demonstrated that LA and, to a lesser extent, aCL represent a risk for thrombosis, the role of antibodies directed against β 2 GPI, prothrombin as well as other targets is still uncertain and controversial. Data from a prospective study showed the presence of antibodies to prothrombin and/or β 2 GPI is a predictor of first or recurrent thromboembolic events in patients with LA and/or aCL. This review intends to highlight the antigen specificity and clinical relevance of APSrelated aPL.

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“…Other study including 195 women with two or more unexplained consecutive miscarriages demonstrated that LA and IgG anti-2 GPI were associated with pregnancy loss but only LA was related to second trimester fetal loss [94]. In contrast, a number of studies showed no association between anti-2 GPI and/or anti-PT and pregnancy loss or reproductive failure [34,[95][96][97][98][99]. Besides, testing for anti-2 GPI seems not to identify additional patients with spontaneous abortion or unexplained fetal death who initially have negative results on LA or aCL assays [97,98].…”

Section: Clinical Role Of Antibodies To 2 Gpi and Prothrombinmentioning

confidence: 99%

Antigen Specificity of Antiphospholipid Syndrome-Related Antiphospholipid Antibodies~!2009-09-28~!2009-11-02~!2010-03-11~!

Forastiero¹

2010

TOAUTOJ

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The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL) and clinically by vascular thrombosis and/or recurrent pregnancy morbidity. The APSassociated aPL are mostly directed against 2-glycoprotein I (2 GPI) and prothrombin. In contrast, aPL linked to infectious disorders are primarily directed against phospholipids and do not tend to be associated with the clinical manifestations of APS. This distinction, however, was later found not to be absolute. Patients with lepromatous leprosy have a high prevalence of true antibodies to 2 GPI, but they do not develop thromboembolic complications. Current evidence suggests that autoantibodies to 2 GPI from APS patients preferentially bind to critical epitopes in domain I of 2 GP1, and leprosyrelated aPL recognizing 2 GPI tend to be directed against domain V. The position of the epitope in the 2 GPI molecule seems to be crucial in defining the pathogenicity of aPL. In addition, an increasing number of other phospholipids-binding proteins with central functions in the regulation of blood coagulation and fibrinolysis are also targeted by APS-related autoantibodies. This review intends to highlight the diverse antigen specificity of aPL and likely further studies would help to understand the different clinical behavior of patients with APS and infections-related aPL.

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Correlation Between β₂‐Glycoprotein Antibodies and Antiphospholipid Antibodies in Patients with Reproductive Failure

Abstract: There is no correlation between beta 2-glycoprotein antibodies and APA status in this population. To date, our most sensitive test for detecting phospholipid autoimmune-mediated in vitro fertilization failure still appears to be the ELISA assay for APA.

Cited by 11 publications

References 16 publications

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Antigen Specificity and Clinical Relevance of Antiphospholipid Syndrome- Related Autoantibodies

Antigen Specificity of Antiphospholipid Syndrome-Related Antiphospholipid Antibodies~!2009-09-28~!2009-11-02~!2010-03-11~!

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Correlation Between β2‐Glycoprotein Antibodies and Antiphospholipid Antibodies in Patients with Reproductive Failure

Abstract: There is no correlation between beta 2-glycoprotein antibodies and APA status in this population. To date, our most sensitive test for detecting phospholipid autoimmune-mediated in vitro fertilization failure still appears to be the ELISA assay for APA.

Cited by 11 publications

References 16 publications

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Antigen Specificity and Clinical Relevance of Antiphospholipid Syndrome- Related Autoantibodies

Antigen Specificity of Antiphospholipid Syndrome-Related Antiphospholipid Antibodies~!2009-09-28~!2009-11-02~!2010-03-11~!

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Correlation Between β₂‐Glycoprotein Antibodies and Antiphospholipid Antibodies in Patients with Reproductive Failure