Correlation in foveal thickness measurements between spectral-domain and time-domain optical coherence tomography in normal individuals

“…Similar to the index patient, the affected brother (II-5, Figure 1B), was heterozygous for both mutations while the unaffected brother (II-1, Figure 1B) carried only the nonsense mutation. (Carpineto et al 2010). …”

Section: Resultsmentioning

confidence: 99%

Novel C2orf71 mutations account for ∼1% of cases in a large French arRP cohort

et al. 2011

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Autosomal-recessive retinitis pigmentosa (arRP) is a genetically heterogeneous group of disorders to which a novel gene, C2orf71, was recently associated. The purpose of our study was to establish the prevalence and nature of C2orf71 mutations in a clinically well-characterized cohort of 345 sporadic and arRP French cases. Direct sequencing of C2orf71 was performed in 209 subjects for whom mutations had previously been excluded by microarray technology and direct sequencing of EYS. Putative pathogenicity of the identified variants was evaluated through cosegregation analysis, screening of more than 188 control chromosomes and prediction programs. We identified two patients compound heterozygous for mutations predicted to lead to a premature stop codon, 3 of which are novel. In addition, 3 patients carried a single variant of likely pathogenicity. Furthermore a large number of novel putative non-disease causing variants were identified, highlighting the extremely polymorphic nature of C2orf71. To our knowledge, our study provides the first large scale screening of C2orf71 in a French arRP cohort through direct sequencing and suggests that it would account for approximately 1% of arRP cases.

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“…Recently, Spectralis HRA þ OCT incorporated a new algorithm of RNFL analysis of the optic nerve head (Figure 1b). [8][9][10][11] As the new technology becomes more ubiquitous, patients with previous TD OCT imaging will likely undergo SD OCT imaging in the future. Therefore, correlation and agreement between the two technologies become clinically relevant to detect change in RNFL thickness in the long term.…”

Section: Introductionmentioning

confidence: 99%

“…SD OCT acquires A-scans B100 times faster than TD OCT, which improves motion artefacts. [8][9][10][11] A commercially available third-generation TD OCT (Stratus OCT; software version 4.0.1, Carl Zeiss Meditec, Dublin, CA, USA) provides image resolution of 8-10 mm (Stratus RNFL analysis printout is depicted in Figure 1a). Previous studies have demonstrated its good reproducibility of retinal measurements and high specificity and sensitivity for detection of glaucomatous damage.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility and agreement in evaluating retinal nerve fibre layer thickness between Stratus and Spectralis OCT

Arthur

Smith

Wright

et al. 2010

Eye

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Purpose To evaluate intra-device reproducibility of retinal nerve fibre layer (RNFL) measurements obtained using Stratus and Spectralis optical coherence tomography, and to analyze inter-device correlation and agreement for these measurements. Design Prospective observational study. Methods A total of 30 normal individuals participated in the study. One eye of each participant was scanned three times during one session by the same operator using Spectralis and Stratus. Intra-class correlation coefficients (ICCs), correlation coefficients (R), and Bland-Altman plots (BAPs) were used to assess reproducibility, correlation, and agreement between the two devices, respectively. Results A significant difference in mean RNFL thickness was seen between Stratus and Spectralis (106.2±6.9 lm vs 100.0±7.3 lm, P ¼ 0.0001). ICCs of RNFL thickness measurements ranged from 0.69 (clock hour 2; 95% confidence interval (95% CI): 0.54, 0.85) to 0.91 (inferior quadrant; 95% CI: 0.86, 0.96) for Stratus and were higher for Spectralis, ranging from 0.87 (temporal-superior sector; 95% CI: 0.79, 0.94) to 0.96 (global and nasal-inferior sector; 95% CI: 0.94, 0.99). Rs of RNFL thickness measurements between the two instruments ranged from 0.61 (temporal quadrant) to 0.

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Correlation in foveal thickness measurements between spectral-domain and time-domain optical coherence tomography in normal individuals

Abstract: Purpose To compare a time-domain (Stratus) and a spectral-domain (Spectralis)

Cited by 24 publications

References 21 publications

Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema

Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema

Novel C2orf71 mutations account for ∼1% of cases in a large French arRP cohort

Reproducibility and agreement in evaluating retinal nerve fibre layer thickness between Stratus and Spectralis OCT

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