Correlation of 18F-FDG PET/CT with pathological features and survival in primary breast cancer

Şimşek, Duygu Has; Şanlı, Yasemin; Kulle, Cemil Burak; Karanlık, Hasan; Kılıç, Burcu; Kuyumcu, Serkan; Önder, Semen; Özmen, Vahit

doi:10.1097/mnm.0000000000000694

Cited by 15 publications

(19 citation statements)

References 29 publications

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“…Has Şimşek et al . [21] in their retrospective study that included 436 patients showed that there was significant difference in SUV max value between HER2-positive and-negative patients. In the present study, there was no significant difference in SUV max value between HER2-positive and -negative patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of maximum standardized uptake values in 18F-Fluorodeoxyglucose positron emission tomography-computed tomography scan with immunohistochemistry and other prognostic factors in breast cancer

2019

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Objectives:The objective of this study was to correlate maximum standardized uptake value (SUVmax) with different immunohistochemical subtypes of breast cancer and other prognostic factors in breast cancer.Subjects and Methods:This was a retrospective study including 219 consecutive patients undergoing whole-body fluorodeoxyglucose positron emission tomography/computed tomography scan for the staging of breast cancer. Out of 219 patients, two were male and 217 were female; age ranged from 26 to 85 years with mean age of 54 years. On histopathological examination (HPE), 197 patients were of invasive ductal carcinoma type and two of lobular type. Histopathological grades, immunohistochemistry (IHC) types, and ki-67 values were compared with SUVmax values.Results:The mean SUVmax of the population was 11.39 (±6.05). The mean SUVmax in different HPE grades was Grade 1 = 6.81 ± 5.6, Grade 2 = 11.4 ± 6.12, and Grade 3 = 13.14 ± 5. The mean SUVmax values in different IHC types were Luminal A = 7.75 ± 4.2, Luminal B = 10.01 ± 5.3, triple negative = 15.26 ± 5.6, and HER2 enriched = 11.27 ± 5.2. The mean SUVmax in high ki-67 patients was 11.97 ± 5.85 compared with 7.25 ± 3.43 patients with low ki-67. Univariate analysis showed significant difference in SUVmax in patients with different grades (P = 0.013), hormone receptor positivity (P ≤ 0.001), ki-67 (P < 0.001), and axillary lymph node positivity (P ≤ 0.001). In multivariate regression analysis, there was significantly higher SUVmax value in triple-negative patients after correcting for tumor size, ki-67 value, axillary lymph node status, and grade of tumor.Conclusion:High SUVmax values were noted in high-grade, high ki-67, triple-negative, and axillary lymph node positive tumors.

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Section: Discussionmentioning

confidence: 99%

Correlation of maximum standardized uptake values in 18F-Fluorodeoxyglucose positron emission tomography-computed tomography scan with immunohistochemistry and other prognostic factors in breast cancer

2019

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“…18 F-FDG PET/CT is a noninvasive diagnostic tool to detect malignant tumors [ 25 ]. Many previous studies have suggested that 18 F-FDG PET/CT has the potential for predicting the status of ER/PR in breast cancer [ 17 – 19 ]. In this study, we demonstrate that the SUVmax was significantly lower in endometrial cancer with positive ER/PR expression than in endometrial cancers that lacked ER/PR expression.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies suggested that 18 F-FDG PET/CT could be useful for predicting molecular phenotype in several malignant tumors, including PD-L1 in bladder cancer [ 14 ], LDHA expression in lung cancer, and FBP1 expression in hepatocellular carcinoma [ 15 , 16 ]. Many previous reports have suggested an inverse correlation between 18 F-FDG accumulation of the primary tumour and ER/PR status in breast cancer [ 17 – 19 ]. However, the correlation between 18 F-FDG accumulation and ER/PR status in endometrial cancer, and the possible underlying molecular mechanisms, are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the expression of oestrogen receptor and progesterone receptor and 18F-FDG uptake in endometrial cancer

Chen

et al. 2020

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Background: Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18 F - fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) can provide metabolic phenotypic information of many malignancies. We investigated whether estrogen receptor (ER)/progestogen receptor (PR) status is correlated with 18 F-FDG uptake, and whether 18 F-FDG PET/CT could be useful for predicting ER/PR status in endometrial cancer. Results: Endometrial cancers in the ER-positive group had lower SUVmax than those in the ER-negative group (12.3 ± 6.2 vs. 19.9 ± 6.6, respectively; P = 0.003). Endometrial cancers in the PR-positive group also had lower SUVmax than those in the PR-negative group (12.4 ± 6.2 vs. 20.0 ± 6.9, respectively; P = 0.005). Multivariate analysis indicated that SUVmax and tumour differentiation grade were significantly associated with both ER and PR status (P = 0.027 and P = 0.044, respectively). ER expression was predicted with an accuracy of 74.2% when a SUVmax value of 15.3 was used as a cutoff point for analysis. Similarly, PR expression was predicted with an accuracy of 74.2%, when a SUVmax value of 15.95 was used as the threshold for analysis. Conclusion: Higher 18 F-FDG accumulation in endometrial cancers is correlated with negative ER/PR expression. 18 F-FDG PET/CT may be used to predict the status of ER/PR and thus aid in optimal treatment decision in endometrial cancers. Methods: We carried out a retrospective analysis on 62 endometrial cancer patients who underwent 18 F-FDG PET/CT before radical treatment. The maximum of standardized uptake value (SUVmax) was calculated from the 18 F-FDG accumulation of the primary tumor. The relationship between SUVmax and ER/PR status was analyzed.

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“…However, given that some malignant lesions were smaller or had a low glucose uptake, the absence of these two criteria did not discard cancer. Based on human experience where there is a correlation between SUVmax and histologic subtypes or grade, among others (26–28), and given the similarities between human breast cancer and canine mammary gland tumors (29), it is reasonable to expect an association between these parameters.…”

Section: Discussionmentioning

confidence: 99%

18F-FDG—PET/CT in Canine Mammary Gland Tumors

et al. 2019

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Medical imaging techniques play a central role in clinical oncology, helping to obtain important information about the extent of disease, and plan treatment. Advanced imaging modalities such as Positron Emission Tomography–Computed Tomography (PET/CT), may help in the whole-body staging in a single procedure, although the lesions should be carefully interpreted. PET/CT is becoming commonly used in canine cancer patients, but there is still limited information available on specific tumors such as mammary cancer. We evaluated the utility of fluorine-18 fluorodeoxyglucose ( 18 F-FDG)-PET/CT to detect malignant lesions in eight female dogs with naturally occurring mammary tumors. A whole-body scan was performed prior to surgery, and mammary and non-mammary lesions detected either on PET/CT or during pre-surgical physical exam were resected when possible and submitted for histopathological examination. Multiple mammary lesions involving different mammary glands were detected in 5/8 dogs, for a total of 23 lesions; there were 11 non-mammary-located lesions in 6/8 dogs, three of these were lung or lymph node metastasis. A total of 34 lesions were analyzed: 22 malignant (19 mammary tumors and three metastatic lesions), and 12 benign (four mammary lesions and eight of non-mammary tissues). Glucose uptake by maximum standardized uptake value (SUVmax) was analyzed and correlated with tumor size, and benign vs. malignant pathology. We found that the minimum tumor size needed to distinguish malignant lesions according to the SUVmax was 1.5 cm; benign and malignant lesions <1.5 cm did not differ in glucose uptake (mean SUVmax = 1.1). In addition, a SUVmax value >2 was 100% sensitive for malignancy. Combining these data, lesions >1.5 cm with a SUVmax >2 had a positive predictive value of 100%. Finally, we did not find an association between SUVmax and histologic subtype or grade, which may be present in a larger sample. Thus, 18 F-FDG PET/CT is useful for distinguishing malignant from benign lesion but further imaging of dogs with diverse tumors, should establish characteristic SUV value cutoffs for detecting primary and metastatic disease, and distinguishing them from benign lesions.

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Correlation of 18F-FDG PET/CT with pathological features and survival in primary breast cancer

Cited by 15 publications

References 29 publications

Correlation of maximum standardized uptake values in 18F-Fluorodeoxyglucose positron emission tomography-computed tomography scan with immunohistochemistry and other prognostic factors in breast cancer

Correlation of maximum standardized uptake values in 18F-Fluorodeoxyglucose positron emission tomography-computed tomography scan with immunohistochemistry and other prognostic factors in breast cancer

Relationship between the expression of oestrogen receptor and progesterone receptor and 18F-FDG uptake in endometrial cancer

18F-FDG—PET/CT in Canine Mammary Gland Tumors

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