Correlation of abdominal fat accumulation and liver steatosis: importance of ultrasonographic and anthropometric measurements

Sabir, Nuran; Sermez, Yurdaer; Kazil, Selcuk; Zencir, Mehmet

doi:10.1016/s0929-8266(01)00153-7

Cited by 105 publications

(75 citation statements)

References 30 publications

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“…17 Therefore, another contribution from the present report consists of emphasizing that the association between NAFLD and features of metabolic syndrome may be extended to the whole Brazilian population. Moreover, these fi ndings indicate that increased fat delivery and/or sustained endogenous biosynthesis in the liver are the most likely physiopathogenic mechanisms underlying the onset of NAFLD under our conditions, to the detriment of the hypothesis of diminished lipoprotein secretion.…”

Section: Discussionmentioning

confidence: 82%

Non-alcoholic fatty liver disease and metabolic syndrome in Brazilian middle-aged and older adults

et al. 2007

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CONTEXT AND OBJECTIVES:Non-alcoholic fatty liver disease (NAFLD) is a complex clinicopathological entity characterized by diffuse or focal fat accumulation in the hepatic parenchyma of patients who deny abusive alcohol consumption. This study aimed to assess idiopathic NAFLD in community-dwelling, middle-aged and older adults living in the Brazilian Federal District. Associations between NAFLD and components of metabolic syndrome and the whole syndrome were investigated. DESIGN AND SETTINGS:This was a cross-sectional study on 139 subjects aged 55 years or older. METHODS:NAFLD was diagnosed by means of clinical procedures, to exclude subjects with signs of liver disorders, abusive alcohol consumption and infl uence from hepatotoxic drugs. Phenotypes were graded based on ultrasound examination. Metabolic syndrome was defi ned using the NCEP ATP III criteria. Laboratory tests were performed to assist clinical examinations and defi ne the syndrome. RESULTS:NAFLD was present in 35.2% of the subjects. Taken together, the two most intense phenotypes correlated with increased serum fasting glucose, triglyceride and VLDL cholesterol levels. Metabolic syndrome was diagnosed in 25.9% of the sample. In addition to associating NAFLD with specifi c traits of metabolic syndrome, non-parametric analysis confi rmed the existence of a relationship (p < 0.05) between the steatotic manifestation and the syndromic condition. CONCLUSION:Compared with the literature, this study reveals greater frequency of idiopathic NAFLD among Brazilian middle-aged and older adults than is described elsewhere. The fi ndings also suggest that impaired glycemic metabolism coupled with increased fat delivery and/or sustained endogenous biosynthesis is the most likely physiopathogenic mechanisms underlying the onset of NAFLD in this population.

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Section: Discussionmentioning

confidence: 82%

Non-alcoholic fatty liver disease and metabolic syndrome in Brazilian middle-aged and older adults

et al. 2007

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“…To date, it has been used to measure subcutaneous [18][19][20] and preperitoneal fat 21,22 as well as visceral thickness (distance between anterior abdominal wall and anterior surface of aorta). 7,21,23 The abdominal wall fat index expressed as a ratio of preperitoneal to subcutaneous fat thickness has been developed to assess the relationships between adipose tissue and obesity-related complications. 1,7,22 These sonographic measurements or indexes also showed significant associations with fatty liver or cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…3 Many studies have shown that fatty liver is associated with increased visceral fat accumulation as determined by anthropometric indexes [4][5][6] and ratio of visceral to subcutaneous fat thickness on imaging. 1,7 These studies have shown that adipose tissue, especially visceral type, plays an important role in the pathogenesis of fatty liver. Mesenteric fat is a specific type of visceral adipose tissue which is drained by the portal circulation, and has been shown to exhibit different metabolic characteristics compared to other types of adipose tissues such as subcutaneous and retroperitoneal fat.…”

Section: Introductionmentioning

confidence: 99%

Mesenteric fat thickness as an independent determinant of fatty liver

Liu

Chan

et al. 2006

Int J Obes

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Objective: Mesenteric fat is drained by the portal circulation and has been suggested to be a key component in obesity-related health risk, notably the metabolic syndrome. There are increasing epidemiological and experimental data showing that fatty liver is another component of this multifaceted syndrome. Given their intimate anatomical and physiological relationships, we hypothesized that mesenteric fat thickness may be independently associated with the risk of fatty liver. To test this hypothesis, we examined the predictive role of various fat deposits including mesenteric fat thickness, and various metabolic variables on the risk of fatty liver. Subjects and methods: A total of 291 Chinese subjects (134 men and 157 women with a mean BMI of 23.7 kg/m 2 , range: 16.5-33.4 kg/m 2 ) underwent ultrasound examination for measurement of mesenteric, subcutaneous and preperitoneal fat thickness, and for diagnosis of fatty liver. Body mass index, waist circumference, and waist-hip ratio were recorded. Blood pressure was measured. Fasting plasma glucose, insulin resistance, high-density lipoprotein cholesterol (HDL-C), triglycerides, low-density lipoprotein cholesterol (LDL-C), liver enzymes were determined by common methods. Results: The subjects with fatty liver had greater abdominal fat thickness and higher anthropometric indexes than those without fatty liver. The subjects with fatty liver also showed higher blood pressure, worse lipid and glycaemic profile compared with those without fatty liver. Using multiple logistic regression analysis, mesenteric fat thickness was a risk factor of fatty liver, independent of body mass index, age, sex, insulin resistance, fasting plasma glucose, lipid and blood pressure. The odds ratio was 1.5 (95% confidence interval: 1.27-1.77) for every 1 mm increase in the mesenteric fat thickness. Measurement of preperitoneal and subcutaneous fat deposits did not show significant associations with fatty liver. Conclusion: Mesenteric fat thickness measured on ultrasound is an independent determinant of fatty liver.

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“…In adults, a strong association between fatty liver and visceral adiposity has been reported, but no associations have been reported with IMCL content (27)(28)(29). Petersen et al (30) reported both intrahepatic triglyceride and IMCL content to be increased in Asian-Indian men compared with Caucasian men.…”

Section: Plasma Lipids and Lipoprotein Composition And Sizementioning

confidence: 99%

Intrahepatic Fat Accumulation and Alterations in Lipoprotein Composition in Obese Adolescents

et al. 2007

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OBJECTIVE -Among other metabolic consequences, a dyslipidemic profile often accompanies childhood obesity. In adults, type 2 diabetes and hepatic steatosis have been shown to alter lipoprotein subclass distribution and size; however, these alterations have not yet been shown in children or adolescents. Therefore, our objective was to determine the effect of hepatic steatosis on lipoprotein concentration and size in obese adolescents.RESEARCH DESIGN AND METHODS -Using fast magnetic resonance imaging, we measured intrahepatic fat content in 49 obese adolescents with normal glucose tolerance. The presence or absence of hepatic steatosis was determined by a threshold value for hepatic fat fraction (HFF) of 5.5%; therefore, the cohort was divided into two groups (HFF Ͼ or Ͻ5.5%). Fasting lipoprotein subclasses were determined using nuclear magnetic resonance spectroscopy.RESULTS -Overall, the high-HFF group had 88% higher concentrations of large VLDL compared with the low-HFF group (P Ͻ 0.001). Likewise, the high-HFF group had significantly higher concentrations of small dense LDL (P Ͻ 0.007); however, the low-HFF group had significantly higher concentrations of large HDL (P Ͻ 0.001). Stepwise multiple regression analysis revealed that high HFF was the strongest single correlate, accounting for 32.6% of the variance in large VLDL concentrations (P Ͻ 0.002).CONCLUSIONS -The presence of fatty liver was associated with a pronounced dyslipidemic profile characterized by large VLDL, small dense LDL, and decreased large HDL concentrations. This proatherogenic phenotype was strongly related to the intrahepatic lipid content. Diabetes Care 30:3093-3098, 2007S tudies from autopsies on 742 children (aged 2-19 years) reported fatty liver prevalence at 9.6%, and in obese children this rate increased to an alarming 38% (1). An imbalance between fatty acid flux and utilization and VLDL secretion leads to an accumulation of triglycerides within the hepatocytes and ultimately to hepatic steatosis (2). It is becoming increasingly clear that fat accumulation in the liver, per se, is not a benign condition (3). Indeed, it is frequently associated with type 2 diabetes in both adults and children (4,5) and has been labeled as the hepatic component of the metabolic syndrome (2,3).Worsening of the dyslipidemic profile has been described in adults in association with insulin resistance and type 2 diabetes (6 -8). Garvey et al. (7) have shown that subjects with type 2 diabetes have larger VLDL and smaller LDL and HDL particles compared with insulinsensitive subjects. The insulin-resistant and type 2 diabetic groups also had greater concentrations of these atherogenic particles. Further studies by Toledo et al. (8) reported that the presence of hepatic steatosis in obese subjects with type 2 diabetes further altered lipoprotein composition compared with type 2 diabetic subjects without fatty liver. Type 2 diabetic subjects with fatty liver had larger triglyceride-rich VLDL particles, smaller LDL and HDL particles, and reduced concentrations o...

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Correlation of abdominal fat accumulation and liver steatosis: importance of ultrasonographic and anthropometric measurements

Cited by 105 publications

References 30 publications

Non-alcoholic fatty liver disease and metabolic syndrome in Brazilian middle-aged and older adults

Non-alcoholic fatty liver disease and metabolic syndrome in Brazilian middle-aged and older adults

Mesenteric fat thickness as an independent determinant of fatty liver

Intrahepatic Fat Accumulation and Alterations in Lipoprotein Composition in Obese Adolescents

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