Correlation of ACE Gene Polymorphism and Hypertension in Stroke Ischemic Patients

Abstract

Stroke is the third highest cerebrovascular disease in the world with high mortality and disability rate that is mostly dominated by ischemic stroke. Genetic factor that had been reported to have an indirect effect in increasing the incidence of ischemic stroke is ACE gene polymorphism. ACE gene polymorphism is characterized by the insertion marked by letter (I) or deletion marked by letter (D) on intron 16, chromosome 17. ACE gene polymorphism has drawn a lot of attention from scientists and had been reported to have an indirect effect in increasing the ischemic stroke incidence through pathogenesis of hypertension and atherosclerosis. In this study, 78 subjects of ischemic stroke consist of 43 subjects with hypertension and 35 subjects with normotension. I allele of ACE gene polymorphism was more dominant than D allele in hypertensive ischemic stroke patients (72.1% > 27,9%) and this dominance was also seen in the incidence of hypertension vs normotension (55.4% > 44.6%). However, the correlation of ACE gene polymorphism with the incidence of hypertension was not statistically significant when compared based on its genotype (p=0.280) and allele (p=0.948).

Angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of ischemic stroke complication among patients with hypertension in the Ethiopian population

“…Based on the allele and its genotype, there is no significant correlation between the ACE gene polymorphism and HTN in patients with IS. In this study, the I allele (72.1%) of the ACE gene polymorphism was more dominant than the D allele (27.9%) in patients with hypertensive IS ( 37 ). In addition, research conducted in South India ( 38 ) showed a link between the ACE II genotype and the I allele, which was exacerbated by factors such as smoking and diabetes among patients with IS.…”