Correlation of admission serum 25-hydroxyvitamin D levels and clinical outcomes in critically ill medical patients

Bhurayanontachai, Rungsun; Maipang, Kotchakorn; Leelawattana, Rattana

doi:10.1016/j.yclnex.2018.04.004

Cited by 2 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study on neurosurgical ICU patients, we also found a negative correlation between APACHE II score and admission serum levels of 25-hydroxyvitamin D 6. Consistent with our results, Bhurayanontachai et al 40 showed that vitamin D levels were significantly correlated with the severity of the illness in medical patients who are critically ill. Chen et al also reported that ICU-hospitalized patients who had 25-hydroxyvitamin D deficiency had significantly higher APACHE II scores than those with 25-hydroxyvitamin D insufficiency or sufficiency 41. It has been well denominated that several factors including malnutrition, lack of exposure to sunlight, decreased renal hydroxylation, and increased tissue conversion of 25-hydroxyvitamin D to 1,25 hydroxyvitamin D may contribute to the vitamin D deficiency in long-stay patients who are critically ill.…”

Section: Discussionsupporting

confidence: 92%

Association of Intestinal Permeability with Admission Vitamin D Deficiency in Patients who are Critically Ill

Eslamian

Ardehali

Hajimohammadebrahim-Ketabforoush

et al. 2020

Journal of Investigative Medicine

View full text Add to dashboard Cite

Emerging data have led to the hypothesis that vitamin D plays a role in promoting epithelial barrier dysfunction. Therefore, intestinal permeability becomes a significant determiner in the future of patients hospitalized in intensive care unit (ICU). The relationship between vitamin D and intestinal permeability remains unclear in patients who are critically ill. The aim of the study is to document the relationship between the admission vitamin D deficiency and markers of intestinal permeability in the critical care setting. This was a single-center, observational, prospective study in the general ICU of a university-affiliated hospital. A sample of 144 ICU-hospitalized adult patients was recruited between January and May 2018. The admission serum 25-hydroxyvitamin D levels were measured and categorized as <20 and ≥20 ng/dL, respectively. Moreover, the admission plasma endotoxin and zonulin concentrations as markers of intestinal permeability were determined in stringent conditions. The association between markers of intestinal permeability and 25-hydroxyvitamin D levels was assessed adjusting for potential confounders through an estimation of a binary logistic regression model. Our results showed that median plasma endotoxin and zonulin decreased with increasing serum levels of vitamin D categories (p=0.001) in the overall study population. Multivariate binary logistic regression analyses showed a significant association between the plasma endotoxin (OR 0.12, 95% CI 0.03 to 0.52) and zonulin (OR 0.91, 95% CI 0.87 to 0.99) levels with serum levels of vitamin D categories in the overall population. Our finding suggests a relationship between vitamin D deficiency and early alterations in intestinal permeability. Thus, evaluating vitamin D levels in patients who are critically ill may be warranted.

show abstract

Section: Discussionsupporting

confidence: 92%

Association of Intestinal Permeability with Admission Vitamin D Deficiency in Patients who are Critically Ill

Eslamian

Ardehali

Hajimohammadebrahim-Ketabforoush

et al. 2020

Journal of Investigative Medicine

View full text Add to dashboard Cite

show abstract

“…This study proposed that a low level of sodium in these patients suggests heart failure severity [ 26 ], but it could also be a heart failure outcome. Diuretic consumption is one cause of drugs producing hyponatremia [ 27 ]. Our results indicated that some CCU patients had higher levels of sodium.…”

Section: Discussionmentioning

confidence: 99%

Electrolyte disturbances in a sample of hospitalized patients from Iraq

2022

View full text Add to dashboard Cite

Electrolyte disturbances are common in ill patients. Several conditions in the intensive care unit (ICU) might be responsible for developing electrolyte disorders, and medications may also contribute to these disturbances. The current study aimed to determine the frequency of electrolyte disturbances and assess the pattern of electrolyte imbalance in hospitalized patients, determining the possible effects of these electrolyte disorders. This cross-sectional study included patients admitted to the intensive care unit, respiratory care unit (RCU), and coronary care unit (CCU) at the Al-Sadar teaching hospital, Najaf, Iraq, from November 2020 to April 2021. The study collected data from two hundred patients regarding demographics, categories of ICUs at admission, comorbidities, and laboratory values at admission. Also, electrolyte levels at ICU admission and during hospitalization were collected from the medical database record. In addition, the patient's age, sex, fasting blood sugar (FBS), body mass index (BMI), B.urea, and creatinine were matched. Na+, K+, ionized Ca++, and Cl serum levels were significantly different during hospitalization. Comorbidities with predominant hypokalemia were found in 80.5%, hypochloremia in 73%, hypocalcaemia in 72%, and hyponatremia in 56.7% of hospitalized patients. Studying the effect of co-morbidities indicated a higher percentage (44%) of admitted patients with ischemic heart diseases, 38 (19%) with digestive diseases, 21 (10.5%) with orthopedic surgery in an emergency, 14 (7%) with pneumonia and lung diseases, 12 (6%) with diabetics, 18 (9%) with sepsis, and 9(4.5%) with seizure. Hospitalized patients may be at higher risk of developing combined electrolytes disorder associated with decreased serum levels of K+, Na+, Ca++, and Cl-. Thus, doctors and clinicians are recommended to observe electrolyte changes and correct them as they seem to negatively impact the outcome and prognosis.

show abstract

Correlation of admission serum 25-hydroxyvitamin D levels and clinical outcomes in critically ill medical patients

Cited by 2 publications

References 41 publications

Association of Intestinal Permeability with Admission Vitamin D Deficiency in Patients who are Critically Ill

Association of Intestinal Permeability with Admission Vitamin D Deficiency in Patients who are Critically Ill

Electrolyte disturbances in a sample of hospitalized patients from Iraq

Contact Info

Product

Resources

About