2008
DOI: 10.2174/1874769800801010071
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Correlation of Age-Related Metabonomic Changes in 1H NMR Serum and Urine Profiles of Rats with Cognitive Function

Abstract: Age related metabonomic changes in young and aged male albino rats have been investigated using Proton Nuclear Magnetic Resonance ( 1 H NMR) spectroscopy. The studies were performed using 'in vivo' behavioral and metabonomic assessment in serum and urine of the rats. Significant changes (p<0.05) were obtained in the concentration of creatinine, allantoin and hippurate in urine. Also significant (p<0.05) alterations were also discernible in acetate, pyruvate, lactate, creatine and glucose in serum. Attempts hav… Show more

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Cited by 7 publications
(2 citation statements)
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“…The urine of Zucker rats and the serum of HFD mice also had lower lactate content than the normal weight rats and the serum [ 14 , 35 ]. The reduced lactate levels can be explained by factors other than HFD induced obesity, including young age and activity [ 36 ].…”
Section: Resultsmentioning
confidence: 99%
“…The urine of Zucker rats and the serum of HFD mice also had lower lactate content than the normal weight rats and the serum [ 14 , 35 ]. The reduced lactate levels can be explained by factors other than HFD induced obesity, including young age and activity [ 36 ].…”
Section: Resultsmentioning
confidence: 99%
“…NMR-based metabolomics have been used to identify biomarkers associated with a variety of diseases including asthma, [87] (a) (b) arthritis, [88] cancer, [89 -91] cardiovascular, [92] diabetes, [93 -95] neurodegenerative, [96,97] and pathogen infections. [98] As an illustration, a clinical study described by van Doorn et al [95] demonstrates the use of 1D 1 H NMR analysis of blood serum samples to distinguish between healthy volunteers and type 2 diabetes mellitus (T2DM) patients.…”
Section: Applications Disease Biomarkersmentioning
confidence: 99%