Citation: Wu Z, Lin C, Crowther M, Mak H, Yu M, Leung CK-S. Impact of rates of change of lamina cribrosa and optic nerve head surface depths on visual field progression in glaucoma. Invest Ophthalmol Vis Sci. 2017;58:182558: -183358: . DOI:10.1167 PURPOSE. To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma.
METHODS.One hundred forty-six eyes of 95 glaucoma patients had optical coherence tomography ONH imaging and VF testing at approximately 4-month intervals for greater than or equal to 5 years. Anterior lamina cribrosa surface depth and ONHSD were measured with reference to (1) Bruch's membrane opening (BMO), and (2) choroid-sclera interface (CSI). The rates of change of ALCSD and ONHSD of individual eyes were measured with linear regression analysis. The hazard ratios (HRs) of the rates of change of ALCSD/ONHSD for prediction of VF progression as per Early Manifest Glaucoma Trial criteria were determined by joint longitudinal and survival models.RESULTS. Using the BMO reference, 23.3% and 28.1% of eyes showed a significant positive trend (posterior displacement), whereas 29.5% and 24.0% showed a significant negative trend (anterior displacement) of ALCSD and ONHSD, respectively. Using the CSI reference, the proportions with a significant negative trend decreased to 11.6% and 14.4%, respectively; and the proportions with a significant positive trend increased to 37.7% and 38.4%, respectively. The HRs of VF progression were 1.06 and 1.11 for each micrometer per year increase in the rates of change of ALCSD BMO and ONHSD BMO , respectively; and 1.07 and 1.09 for each micrometer per year increase in the rates of change of ALCSD CSI and ONHSD CSI , respectively.
CONCLUSIONS.Identifying fast progressors of posterior ALCS/ONHS displacement is relevant to the management of glaucoma patients as they have a higher risk of VF progression.Keywords: optic nerve head surface depth, anterior lamina cribrosa surface depth, optical coherence tomography O ptic nerve head (ONH) deformation is a defining feature of glaucoma. While confocal scanning laser ophthalmoscopy (CSLO) and optical coherence tomography (OCT) have been widely adopted for measurement of the neuroretinal rim, [1][2][3][4][5][6] parameters like anterior lamina cribrosa surface depth (ALCSD) and ONH surface depth (ONHSD) are rarely examined in clinical practice. Studies reporting long-term, progressive LC and ONH surface deformation in glaucoma patients are sparse. We previously investigated the longitudinal changes of ALCSD and ONHSD in glaucoma patients with reference to Bruch's membrane opening (BMO) using an event analysis. 7 However, event analysis cannot reveal how fast an individual eye is progressing. The rates of change of ALCSD and ONHSD over the course of glaucoma progression have not been reported. The significance of measurement of LC and ONH deformation in the management of glaucoma patients remains unclear.Studie...