2015
DOI: 10.1371/journal.pone.0144156
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Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes

Abstract: PurposeTo assess and compare choroidal thickness changes related to aging, we determined whether changes are due to thinning of the choriocapillaris plus Sattler's (CS) layer and/or the large vessel layer in healthy eyes using swept-source optical coherence tomography (SS-OCT) at a wavelength of 1,050-nm.MethodsWe studied 115 normal eyes of 115 healthy volunteers, all with refractive errors of less than -6 diopters. All 115 eyes underwent analysis of choroidal thickness at the fovea, the CS layer and the large… Show more

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Cited by 127 publications
(88 citation statements)
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“…Several previous studies based on structural OCT already reported a thinning of choroidea and CC in healthy subjects, suggesting physiological and age-dependent alterations in these layers [33] . A similar consistency between histologic findings and OCT-A measurements was found for the inner and middle retinal layers correspondingly showing region-specific vascular patterns [34] .…”
Section: Correlation Between CC Decorrelation Signal and Agementioning
confidence: 84%
“…Several previous studies based on structural OCT already reported a thinning of choroidea and CC in healthy subjects, suggesting physiological and age-dependent alterations in these layers [33] . A similar consistency between histologic findings and OCT-A measurements was found for the inner and middle retinal layers correspondingly showing region-specific vascular patterns [34] .…”
Section: Correlation Between CC Decorrelation Signal and Agementioning
confidence: 84%
“…While 29.5% and 24.0% of eyes exhibited anterior displacement of the anterior LC and the ONH surfaces over 5 years, respectively, when the ALCSD and ONHSD were measured with reference to the BMO, the respective proportions significantly decreased to 11.6% and 14.4% when the ALCSD and ONHSD were measured with reference to the CSI. The differences in the proportions of eyes with significant anterior LC and ONH surface displacement between BMO-and CSI-based measurements could be attributed to age-related 22 and/or glaucoma-related reduction of choroidal thickness. 23 Progressive choroidal thinning can engender an appearance of anterior displacement of the LC and the ONH surface with reference to the BMO, which may not be evident when the Axial length and central corneal thickness were not included in the final multivariable models as their association with the rates of change of ALCSD CSI and ONHSD CSI were not significant (P ‡ 0.641).…”
Section: Discussionmentioning
confidence: 97%
“…According to several studies, the choroidal vasculature thickness decreases at rates ranging from 0.72 μm to 2.98 μm each year, as described by Wakatsuki et al. using swept-source OCT [25], [28], [29], [30], [31].…”
Section: Discussionmentioning
confidence: 99%