Correlation of Anti-Inflammatory Activity with Inhibition of Prostaglandin Synthesis Activity of Nonsteroidal Anti-Estrogens and Estrogens

Lerner, Leonard J.; Carminati, Paolo; Schiatti, P

doi:10.3181/00379727-148-38532

Cited by 19 publications

(6 citation statements)

References 10 publications

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“…Diethylstilbestrol suppresses serum levels of testosterone better than castration because it reduces the level of serum dehydroepiandrosterone (27). Diethylstilbestrol and indomethacin also inhibit prostaglandin synthesis (28), an event related to apoptosis. Like other nonsteroidal anti-inflammatory drugs, indomethacin has antineoplastic properties (29,30).…”

Section: Discussionmentioning

confidence: 99%

Herbal Composition PC-SPES for Management of Prostate Cancer: Identification of Active Principles

Sovák

Seligson²,

Konas³

et al. 2002

CancerSpectrum Knowledge Environment

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The phytochemical composition of PC-SPES varied by lot, and chemical analyses detected various amounts of the synthetic drugs diethylstilbestrol, indomethacin, and warfarin and several natural products. To qualify for clinical pharmacologic exploration, nutritional supplements including herbal mixtures should meet standards of quality control under the Good Manufacturing Practice system, and the manufacturers of such supplements should provide reliable analytical quality assurance.

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Section: Discussionmentioning

confidence: 99%

Herbal Composition PC-SPES for Management of Prostate Cancer: Identification of Active Principles

Sovák

Seligson²,

Konas³

et al. 2002

CancerSpectrum Knowledge Environment

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“…This report mentioned that clomiphene, possessing aspects as a weak estrogen and as an anti-estrogen, was a very potent PG synthesis inhibitor, being equal in this parameter to indomethacin. 16 From this report, CC acted as a PG synthesis inhibitor and raised PG dehydrogenase concentration in the human endometrium. Moreover, it is well known that the use of non-steroidal anti-inflammatory drugs (NSAIDs) inhibit both COX-1 and COX-2.…”

Section: Discussionmentioning

confidence: 80%

“…There was a very interesting report concerning the characteristics of clomiphene citrate. This report mentioned that clomiphene, possessing aspects as a weak estrogen and as an anti‐estrogen, was a very potent PG synthesis inhibitor, being equal in this parameter to indomethacin . From this report, CC acted as a PG synthesis inhibitor and raised PG dehydrogenase concentration in the human endometrium.…”

Section: Discussionmentioning

confidence: 81%

Prostaglandin therapy during the proliferative phase improves pregnancy rates following frozen embryo transfer in a hormone replacement cycle

Nakagawa¹,

Ojiro²,

Jyuen³

et al. 2014

J of Obstet and Gynaecol

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Aim: To determine the efficacy of prostaglandin administration during the proliferative phase in order to improve pregnancy rates following frozen embryo transfer during a hormone replacement cycle (HRC). Methods: From September 2010 through March 2012, patients (n = 135) were recruited who had undergone oocyte retrieval during a stimulation cycle with clomiphene and had deferred fresh embryo transfer (ET) due to a thin uterine endometrium. All patients were less than 40 years of age and underwent thawed ET following all embryo cryopreservation, and were randomly divided into two groups for thawed ET using a conventional hormone replacement cycle with or without prostaglandin derivatives (prostaglandin or conventional group). Prostaglandin derivatives were administrated during the proliferative phase. Pregnancy and implantation rates following frozen ET were compared between the two groups. Results: Although the endometrial thickness on the day of ET was similar for the prostaglandin and conventional groups, the pregnancy and implantation rates for the prostaglandin group were 40.0% and 22.0%, respectively, which was significantly higher than the rates for the conventional group (P < 0.01). Conclusion: Among patients who avoided fresh ET due to a thin endometrium, the pregnancy rate following a thawed cycle was low. However, it was improved when prostaglandin derivatives were used during the proliferative phase.

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“…There was a very interesting report concerning the characteristics of CC. This report mentioned that CC, possessing aspects as a weak estrogen and as an anti-estrogen, was a very potent prostaglandin synthesis inhibitor, being equal in this parameter to indomethacin [17]. From this report, CC acted as a prostaglandin synthesis inhibitor and raised prostaglandin dehydrogenase concentrations in human endometrium.…”

Section: Discussionmentioning

confidence: 81%

Clomiphene citrate affects the receptivity of the uterine endometrium

Nakagawa

Kaneyama

Nishi

et al. 2014

Reprod Medicine & Biology

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Correlation of Anti-Inflammatory Activity with Inhibition of Prostaglandin Synthesis Activity of Nonsteroidal Anti-Estrogens and Estrogens

Cited by 19 publications

References 10 publications

Herbal Composition PC-SPES for Management of Prostate Cancer: Identification of Active Principles

Herbal Composition PC-SPES for Management of Prostate Cancer: Identification of Active Principles

Prostaglandin therapy during the proliferative phase improves pregnancy rates following frozen embryo transfer in a hormone replacement cycle

Clomiphene citrate affects the receptivity of the uterine endometrium

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