Correlation of anti‐Mullerian hormone with humanchorionic gonadotropin test in the evaluation of testicular function of children with 46 XY male hypogonadism: Use of anti‐Mullerian hormone as abiomarker

Abstract

Aim It is challenging to evaluate reproductive potential during childhood. These challenges necessitate the use of invasive dynamic tests. Although the anti‐Mullerian hormone (AMH) is a reliable biomarker in evaluating testicular function, especially in the pre‐pubertal period, there are uncertainties concerning its use in a clinical setting. This study is focused on comparing the AMH and human chorionic gonadotropin (hCG) test in boys with hypogonadism. Methods A total of 160 boys aged between 0 and 18 years who presented with complaints associated with hypogonadism were prospectively enrolled in the study. All children were assigned to the following five groups: gonadal disorders (n = 34), androgen synthesis and end organ effect disorder (n = 48), isolated genital malformation disorders (n = 57), hypogonadotropic hypogonadism (n = 15) and constitutional delayed puberty (n = 6). All children underwent a short 3‐day hCG test (1500 U/m2/day). The concordance and correlation were evaluated between the hCG test and AMH. Results All groups exhibited a strong correlation (r160 = 0.689) and strong concordance (Kappa coefficient160 = 0.7) between the AMH and hCG test. Values of AMH higher than 32.7 pmol/L and hCG responses higher than 86 pmol/L were significant as indicative markers of functional testicular tissue presence. Conclusions This study has shown that there is a strong correlation between the AMH and short‐term hCG test and that values of AMH higher than 32.7 pmol/L and stimulated testosterone higher than 86 pmol/L can be used as indicators of functionally sufficient testicular tissue. These results indicate that AMH value can be used as a reliable and useful biomarker in the evaluation of the testicular function in 46 XY hypogonadism.

Categorization of differences of sex development among Egyptian children and the role of antimullerian hormone and inhibin B

“…Our results showed a positive correlation between AMH level and post-HCG stimulation DHT and testosterone levels. However, there was no significant correlation between the In our study, 90 % patients with PAIS, 100% of patients with 5-alpha-reductase deficiency and 90 % of those with anatomical defects had normal AMH levels, which was consistent with the results of Szarras-Czapnik et al (36) Also Karaoglan reported normal AMH in patients with AIS and those with anatomical defects; however, the authors also found relatively low AMH levels in patients with 5-alpha-reductase deficiency (37). Our results demonstrated low AMH levels in more than half of patients with partial gonadal dysgenesis, which agreed with the results of Karaoglan (37).…”

Segmental testicular infarction in adolescent:experience of new treatment and testicular function monitoring

“…Considering that the patient's genital development was in the G2PH2 stage, we deemed it necessary to monitor testicular function. Karaoglan et al's [ 10 ] study suggests that AMH testing could serve as a reliable and practical biomarker for evaluating testicular function in adolescents with hypogonadism. INH B is a good indicator of the degree of supporting cell differentiation, and its concentration is related to spermatogenic function [ 11 ].…”