Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women

Cm, Banki

doi:10.1007/bf01670278

Cited by 61 publications

(11 citation statements)

References 35 publications

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“…As revealed by the multiple regression analysis, melancholic features provide a significant contribution to 5-HT2 receptor responsiveness measure that is distinct and independent of irritability. Some studies have shown an inverse relationship between CSF 5-HIAA and anxiety in major depression (41,42,52). Several studies reported increased brain or platelet 5-HT2 receptors in patients with recent suicide attempts or with a lifetime history of suicidal behaviour (3-6, 50).…”

Section: Discussionmentioning

confidence: 99%

“…However, Meltzer et al (33) function to history of suicide attempt rather than to suicidal ideation. Some studies have shown an inverse relationship between CSF 5-HIAA and anxiety in major depression (41,42,52). A post-synaptic 5-HT receptor system hypersensitivity hypothesis of anxiety has also been proposed that suggests that some anxiety states, and in particular panic disorder, are characterized by hypersensitive post-synaptic 5-HT receptors (18).…”

Section: Discussionmentioning

confidence: 99%

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5‐HT2 receptor antagonism and slow‐wave sleep in major depression

Staner

Kempenaers

Simonnet

et al. 1992

Acta Psychiatr Scand

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Specific sleep disturbances such as reduced slow-wave sleep (SWS) and decreased serotonergic (5-HT) activity have been observed in depressive disorders. Ritanserin, a specific 5-HT2 receptor antagonist, has been shown to increase SWS in healthy subjects. This study explored the effects of a single dose or ritanserin (5 mg) on sleep electroencephalography in 18 major depressed patients and in 10 control subjects. Ritanserin affected SWS differently in the two groups. Although stage 3 increased significantly in the groups, in contrast to controls, there was no significant effect of ritanserin on stage 4 in depressed patients. In the depressed group, irritability and DSM-III-R melancholic type predicted 40% or the variance of stage 4 increment after ritanserin, as assessed by stepwise multiple regression. These results are in agreement with a potential 5-HT disturbance, particularly at the 5-HT2 receptor level, in some clinical forms of depression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

5‐HT2 receptor antagonism and slow‐wave sleep in major depression

Staner

Kempenaers

Simonnet

et al. 1992

Acta Psychiatr Scand

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“…Lower levels of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, in cerebrospinal fluid (CSF), have been found in both depressed and nondepressed patients who made violent suicide attempts compared to those whot did not (Asberg etal., 1976;Agren, 1980;van Praag, 1983;Banki and Arato, 1983). Reduced CSF 5-HIAA levels has also been found to be associated with high level of aggressive behavior towards self and others (Asberg etal., 1980(Asberg etal., , 1987, personality disorders with impulsive violent behavior (Brown et al, 1979) and high levels of anxiety and agitation in depressed patients (Banki, 1977;Asberg et al, 1980;Leckman etal., 1980).…”

Section: Introductionmentioning

confidence: 99%

Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims

Matsubara

Arora

Meltzer

1991

J. Neural Transmission

142

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The density of 5-HT1A binding using 3H-8-hydroxy-2-(di-n-propyl-amino) tetralin (8-OH-DPAT) as binding ligand, was studied in human frontal cortex of suicide victims and normal controls who died due to medical disease or accidentally. There was no difference in the maximum number of binding site (Bmax) or Kd (an inverse measure of affinity) of 5-HT1A receptor binding sites between normal controls and the entire group of suicide victims. However, nonviolent suicides had significantly higher Bmax (22-25%) compared to both controls and violent suicides. A negative correlation between age and Bmax of 5-HT1A binding sites was found in male controls but not in female controls or suicide victims. This relationship was less apparent among the male controls over age 60.

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“…Such sepa rate analysis of distinct psychopathological symptoms as functions of bio chemical disorders has been already suggested by van Praag [32] and Zarifian and Loo [39]; by the use of explicit operational criteria for symp tom definition concordance can easily exceed 0.50 (intraclass correlation coefficient) and thus they serve as a solid base in the search for neurochem ical correlations. In fact, agitation and dopamine metabolism have been found to be interrelated in patients with depression, parkinsonism and other conditions independent of the diagnosis [30], There arc indications that a similar relationship may exist between the symptom cluster insom nia-agitation-anxiety and serotonin metabolism [9,19]. In the present study, CSF 5HIAA correlated positively with both hallucinations and dis orientation but not with agitation; this argues against the view that its CSF increase was only a consequence of a reduced egress or of motor hyperac tivity.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Amine Metabolites in Delirium tremens

Bánki¹,

Molnár

1981

Psychopathology

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Cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA) and tryptophan (TRY) were measured in 14 male alcohol-dependent patients with delirium tremens. Lumbar punctures were performed immediately after admission following a standardized psychiatric examination and symptom rating in a drug-free state. Results were compared with a control group consisting of 32 neurological patients with only peripheral disorders, excluding spinal processes and abnormal routine CSF findings. All three substances were significantly increased in delirium tremens; 5HIAA showed the most marked and TRY the least pronounced increase. The statistical correction for age, height and body weight did not decrease but somewhat increased the differences. Duration of alcohol abuse did not account for the observed metabolic changes; severity of delirium tremens, however, correlated significantly with the 5HIAA and to a lesser degree with the HVA level. The further analysis revealed a differential relationship of the amine metabolite concentrations to some prominent symptoms: agitation was significantly dependent only on the HVA level while disorientation and hallucination seemed to be determined mostly by the serotonin metabolite 5HIAA in the CSF. TRY concentration proved to be unrelated to either global severity or any of these symptoms.

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Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women

Cited by 61 publications

References 35 publications

5‐HT2 receptor antagonism and slow‐wave sleep in major depression

5‐HT2 receptor antagonism and slow‐wave sleep in major depression

Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims

Cerebrospinal Fluid Amine Metabolites in Delirium tremens

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