Correlation of Bariatric Surgery Effect on Lipid Profile Among Obese Patients

Zaki, Mohammed Khaled S; Al-Jefri, Omamah H; Kordi, Reem E; Aljohani, Amal H; Rizq, Maha A; Kasem, Ghaday H; Abuasidah, Shahad B

doi:10.7759/cureus.18118

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…When stratified by DR level at index date no increased odds were seen in either group, which is in accordance with previous findings [ 8 ], however the overall small number of events in our study must be taken in to consideration. We found a significant postoperative drop in plasma TG amongst our case population, which is in accordance with previous studies [ 24 – 26 ].…”

Section: Discussionsupporting

confidence: 93%

Bariatric surgery in individuals with type 2 diabetes is not associated with short or long-term risk of diabetic retinopathy progression: results from a nationwide cohort study

Thykjær

Rosengaard

Andersen³

et al. 2023

Acta Diabetol

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Aims Bariatric surgery is used to induce weight loss and glycemic stability in type 2 diabetes (T2D). It has been a concern that this may lead to early worsening of diabetic retinopathy (DR) due to a rapid decline in HbA1c. In this study, we evaluated the risk of short and long-term DR development and need for ocular intervention in an entire nation of individuals with T2D undergoing bariatric surgery. Methods The study comprised a national, register-based cohort of individuals with T2D screened for DR. Cases were matched by age, sex and DR level at the date of surgery (index date) with non-bariatric controls. We extracted information on DR levels, in- and outpatient treatments, pharmaceutical prescriptions and laboratory values. We evaluated worsening of DR (incident and progressive DR) at follow-up (6 and 36 months). Results Amongst 238,967 individuals with T2D, who attended diabetic eye screening, we identified 553 that underwent bariatric surgery (0.2%) and 2677 non-bariatric controls. Median age was 49 years, and 63% were female. Cases had more comorbidities, lower HbA1c as well as more frequent use of glucose-lowering and antihypertensive medication than controls at index date. In a fully adjusted logistic regression model, the risk of DR worsening for cases was not significantly different compared to controls, neither short-term (OR 0.41 [CI 95% 0.13; 1.33], p = 0.14) nor long-term (OR 0.64 [CI 95% 0.33; 1.24], p = 0.18). Conclusions In this nationwide study, bariatric surgery did not associate with increased risk of short- or long-term DR worsening.

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Section: Discussionsupporting

confidence: 93%

Bariatric surgery in individuals with type 2 diabetes is not associated with short or long-term risk of diabetic retinopathy progression: results from a nationwide cohort study

Thykjær

Rosengaard

Andersen³

et al. 2023

Acta Diabetol

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“…LDL and HDL cholesterol, and triglyceride. Even if we did not reach statistical signi cance our results were in line with those already reported: metabolic surgery has a positive effect on lipid pro le, lowering triglyceride, total cholesterol and LDL cholesterol and increasing the level of HDL cholesterol [21].…”

Section: Discussionsupporting

confidence: 78%

Short-term Changes in Tnf-alpha, Il-6 and Adiponectin Following Bariatric Surgery in Romanian Obese Adults – an Observational Case-control Study

Ion,

Hutanu,

Sala

et al. 2024

Preprint

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Background: Bariatric surgery plays an impotant role in immnological modulation by reducing levels of systemic inflammatory markers, such as interkleukin-6 and tumor necrosis factor alpha. The goal of this study is to establish the possible correlations between obesity-linked chronic systemic inflammation, materialized objectived through the cytokine plasma profile and weight loss process after metabolic surgery. Materials and methods: An observational cohort study included two categories: patients with obesity – bariatric group and patients without obesity – control group between February 1, 2021 and March 1, 2023. Baseline characteristic, anthropometric measurements, biochemical assessments and inflammatory biomarkers were taken both before surgery and one year after the procedure. The bariatric group undergo two types of bariatric procedures: majority were performed to laparoscopic sleeve gastrectomy whereas a select few of patients underwent one anastomosis laparoscopic gastric bypass. Results: A prospective study comprising 55 Caucasian patients - 33 patients with morbid obesity mean age of 41.76±10.78 and mean BMI of 43.34± 7.51 kg/m2. We note that preoperative levels of IL-6 have a positive correlation with WC (r=0.354, p=0.043), weight (r=0.549, p=0.001) and BMI (r=0.520, p=0.002). After applying the Kruskal Wallis Test and Dunn’s Test significant differences for IL-6 (p=0.010, p<0.05) and adiponectin (p=0.024, p<0.05) were obtained. No correlation was found between adiponectin, IL-6, TNF- α and anthropometric indices after surgery. Conclusions: Our study demonstrated that bariatric surgery significantly changes the level of inflammatory cytokines one year after operation. We failed to demonstrate the predictive role of preoperative plasma cytokine profile for the weight loss process after metabolic procedures.

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“…Bariatric surgery is an effective treatment for morbid obesity and can lead to improvement in several cardiovascular risk factors such as hypertriglyceridemia, hypertension, diabetes, oxidative stress, and others [ 1 ]. There are several reports demonstrating improvement in all parameters of the lipid profile after bariatric surgery [ 2 , 3 , 4 ], conversely, some other reports showed no change, or changes only in TG [ 5 , 6 ]. The discrepancy between studies is unknown, possibly factors such as diet, exercise, and others play a relevant role.…”

Section: Introductionmentioning

confidence: 99%

Bariatric Surgery Induced Changes in Blood Cholesterol Are Modulated by Vitamin D Status

et al. 2022

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The effect of metabolically active bariatric surgery treatment on lipid metabolism is inconclusive. The authors of this study presume that initial vitamin D status may play a regulating role in influencing the beneficial post-effects of bariatric surgery, especially the lipid profile. The biochemical data obtained from 24 patients who had undergone laparoscopic one-anastomosis gastric bypass (OAGB) at baseline, 3 months before the surgery, at the time of surgery, and 6 months later, demonstrate that vitamin D status influenced the postoperative lipid profile. The baseline established the partition line which divided patients into two groups according to the stated calcidiol initial concentration level of 32 ng/mL. The data shows that OAGB induces a decrease in TG and hsCRP while increasing HDL. Conversely, in patients whose 25(OH)D3 was below 32 ng/mL TC significantly increased while those above this concentration remained in the normal physiological range. The changes induced by OAGB in TG, glucose, and hsCRP were similar in both groups. Unexpectedly, the surgery did not affect vitamin D metabolites. In conclusion, the results of the study suggest that a higher concentration of serum 25(OH)D3 may enhance the protective effects of OAGB.

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Correlation of Bariatric Surgery Effect on Lipid Profile Among Obese Patients

Cited by 4 publications

References 17 publications

Bariatric surgery in individuals with type 2 diabetes is not associated with short or long-term risk of diabetic retinopathy progression: results from a nationwide cohort study

Bariatric surgery in individuals with type 2 diabetes is not associated with short or long-term risk of diabetic retinopathy progression: results from a nationwide cohort study

Short-term Changes in Tnf-alpha, Il-6 and Adiponectin Following Bariatric Surgery in Romanian Obese Adults – an Observational Case-control Study

Bariatric Surgery Induced Changes in Blood Cholesterol Are Modulated by Vitamin D Status

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