Correlation of BCL-2 and ERα mRNA Expression with the Clinical Chemotherapeutic Response in Breast Cancer

Chen, Ho-Mei; Chao, You‐Chen; Cheng, Muh-Liang; Tang, Haoning; Hsu, Chung-Te

doi:10.3923/jms.2017.31.37

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…The recent study about KI-67, BCL-2, ERα as predictor of clinical response to chemotherapy in breast cancer have done in our center. 6,14 The characteristics of this study, mostly breast cancer patients were found in the age group >50 years with 30 cases (60%) at least 30 years and a maximum of 82 cases.…”

Section: Discussionmentioning

confidence: 88%

Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer

Maulidan¹,

Syamsu²,

Thabry³

et al. 2019

Int J Res Med Sci

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Background: Cyclooxygenase-2 (COX-2) is involved in the carcinogenesis process and tumor progression into cancer. It has been reported recently, there was a COX-2 expression at breast cancer. Patients with a high level of COX-2 expression can have a local recurrence and decrease life expectancy, and an increase of COX-2 expression in tissue likelihood has prognostic value. This study aims to correlation cyclooxygenase-2 (cox-2) expression and histopathological grading in locally advanced breast cancer patient in AW Sjahranie Hospital in Samarinda city.Methods: This study was an observational study with crossectional design to analysis the correlation COX-2 expression and histopathological grading in patients with locally advanced breast cancer and using data analysis with the Chi-Square test.Results: The results showed that the correlation was not significant (P>0.05), where there was no correlation of COX-2 expression with histopathological grading (P=0.221) and there was no correlation with the last condition of patients (P=0.61). Although patients with breast cancer high grade and moderate grade percentages were significantly higher in positive COX-2 than in COX-2 negative expression.Conclusions: There were no correlation between COX-2 expression and histopathological grading and there was no significant relationship between COX-2 expression and the last condition, as evidenced by the statistical test results showing that the differences were not significant.

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Section: Discussionmentioning

confidence: 88%

Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer

Maulidan¹,

Syamsu²,

Thabry³

et al. 2019

Int J Res Med Sci

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“…Next, the slides were placed in 1.5% blocking serum and incubated for 5–10 min. The slide was then incubated for 60 min in primary antibodies at 1:200 (human monoclonal NFкB p65 antibody, ScyTek Laboratories, Logan, UT, USA) according to the manufacturer's instructions [ 17 ]. Then, it was dripped with TrekAvidin universal link secondary antibody (Biocare Medical) according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

The relationship between NFKB, HER2, ER expression and anthracycline -based neoadjuvan chemotherapy response in local advanced stadium breast cancer: A cohort study in Eastern Indonesia

Manginstar

Islam

Sampepajung

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction Neoadjuvant chemotherapy has become the standard form of treatment for locally advanced breast cancer. Chemoresistence is a problem that limits the effectiveness of chemotherapy. Therefore, predictive biomarkers are needed to choose the appropriate chemotherapy to the right patient. The role of NF-кb expression as a predictive biomarker of neoadjuvant chemotherapy response needs to be investigated in patients with locally advanced breast cancer who are treated with a regimen of cyclophosphamide-doxorubicin-5FU (CAF). Methods This observational study used the prospective cohort method to examine 62 samples. CAF was administered at 3-week intervals for 3 cycles of chemotherapy. The data utilized in this study include the positive and negative expression of NF-κB, ER, and HER2 overexpression. The cases were divided into groups that were responsive and non-responsive to the neoadjuvant chemotherapy. Results The average age in the youngest group was 26 years, and that in the oldest was 66 years. The highest age group was subjects in their 50s, which had 26 cases (41.9%). The majority of the cases were moderate grade with 38 cases (61.3%). The percentage of responsive subjects was higher in the groups with negative NF-κB expression (82.5%), positive HER2 status (85.7%), and negative ER status (71.9%). It was found that 37 cases (59.7%) were responsive to CAF, while 25 cases (40.3%) were non-responsive. There was a significant relationship between NF-κB expression and chemotherapy response (p < 0.05), and the percentage of responsive subjects was higher among those with negative NF-κB expression (82.5%) than positive NF-κB expression (18.2%). Conclusion NF-κB expression, ER status, and HER2 have a significant relationship with the response to anthracycline-based neoadjuvant chemotherapy for local advanced breast cancer, and NF-κB expression has the most significant relationship with the chemotherapy response. Therefore, NF-κB expression should be considered as a predictive biomarker for the response to CAF regimens.

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“…102-112 protein anti apoptosis yaitu B-cell lymphoma 2 (BCL2), menyebabkan penekanan terhadap protein pro apoptosis yaitu BCL2 associated X (BAX) dan melemahkan signal nitride oxyde (NO). Sebagai akibatnya kematian sel tidak terjadi dan sel ganas terus berproliferasi untuk berkembang (Divvela et al, 2010;Prihantono et al 2017). Jalur kedua, peningkatan ekspresi COX-2 akan menyebabkan stimulasi terhadap CD44.…”

Section: Hasil Dan Pembahasanunclassified

Original Article HUBUNGAN EKSPRESI CYCLOOXYGENASE-2 (COX-2) DENGAN DISEASE FREE SURVIVAL DAN OVERALL SURVIVAL PADA PENDERITA KANKER PAYUDARA

Prihantono

Juhamran

Abidin³

et al. 2019

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Cyclooxygenase-2 (COX-2) berperan dalam pertumbuhan tumor dan metastasisnya yang berdampak pada buruknya prognosis. Tujuan penelitian ini untuk mengetahui hubungan ekspresi COX-2 terhadap disease free survival dan overall survival pada pasien kanker payudara. Penelitian ini bersifat observasional menggunakan desain kohort dengan periode follow up selama 24 bulan. Hasil: Ekspresi COX-2 ditemukan pada 21 sampel (42%) dari 50 pasien kanker payudara. Selama follow up 24 bulan, lama DFS pada COX-2 negatif (20,1 bulan) lebih lama dibandingkan pada COX-2 positif (14,0 bulan) dan menunjukkan hubungan yang signifikan (p<0,01). Lama OS pada COX-2 negatif (22,6 bulan) lebih lama dibandingkan pada COX-2 positif (17,8 bulan) yang juga menunjukkan hubungan yang signifikan (p<0,01). Terdapat hubungan yang signifikan antara ekspresi COX-2 dengan disease free survival dan overall survival pada pasien kanker payudara. COX-2 bisa dijadikan salah satu faktor prognostik kanker payudara.

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Correlation of BCL-2 and ERα mRNA Expression with the Clinical Chemotherapeutic Response in Breast Cancer

Cited by 5 publications

References 32 publications

Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer

Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer

The relationship between NFKB, HER2, ER expression and anthracycline -based neoadjuvan chemotherapy response in local advanced stadium breast cancer: A cohort study in Eastern Indonesia

Original Article HUBUNGAN EKSPRESI CYCLOOXYGENASE-2 (COX-2) DENGAN DISEASE FREE SURVIVAL DAN OVERALL SURVIVAL PADA PENDERITA KANKER PAYUDARA

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