Background: Anthropometric measurements of the new-borns are important indicators of their intra-uterine growth and development; and could be reliable predictors of their health status. This study was carried out to determine the relationships between occipito-frontal head circumference and occipito-heel length to the birth weight of singleton term newborns in ESUTH, Enugu. Methods: A total of 1000 (500 males and 500 females) live singleton term babies whose mothers gave consent for participation and satisfied the inclusion criteria were consecutively recruited from the labour ward of ESUTH, Enugu from June 1, 2015 to May 31, 2017. The birth weight (BW), occipito-frontal circumference (OFC) and occipito-heel length (OHL) of the new-borns were measured and documented. The weight and OHL of the new-borns were used to calculate the babies' body mass index (BMI). Data obtained was entered into SPSS version 20 and then analysed. Results: The mean values of their OFC, OHL and BW were 34.6±2.2 cm; 49.8±3.0 cm and 3.3±1.4 kg respectively. There was a significant difference between the OFC (p=0.012) and OHL (P=0.035) but not in BW (P=0.220) and BMI (p=0.446) in males neonates compared to females. A significant correlation (Pearson's) of OFC (r=0.149; P=0.000) and OHL (r=0.145; p=0.000) with birth weight was also found. There was also a significant correlation of OFC (r=0.106; P=0.001) and OHL (r=-0.156; p=0.000) with BMI. Conclusion: The birth weight and BMI of new-born babies are good determinants of their OFC and OHL.